Reactome | Ubiquitin-dependent degradation of Cyclin D

Ubiquitin-dependent degradation of Cyclin D

Stable Identifier

R-HSA-75815

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Ubiquitin-dependent degradation of Cyclin D

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Cyclin D turnover is regulated by ubiquitination and proteasomal degradation which are positively regulated by cyclin D phosphorylation on threonine-286 (Diehl et al., 1997).

After the Cyclin D serves the role of mediating reactions by Cdk4 and Cdk6, it is shuttled to the cytoplasm and degraded in a ubiquitin-dependent manner. Whether Cdk4 and Cdk6 are truly redundant is a topic still under investigation, although both the kinases are required for normal cell cycle progression.

Destruction of the D type cyclins accompanies the end of the G1 phase, and the E type cyclins are involved in transition of the cell from G1 to S phase.

Literature References

PubMed ID	Title	Journal	Year
9136925	Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway Sherr, CJ, Zindy, F, Diehl, JA	Genes Dev	1997