Formation of RAD50:MRE11 complex

Stable Identifier
R-HSA-75172
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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MRE11 has both manganese dependent ssDNA 3'->5' exonuclease and endonuclease activities. MRE11 associates with RAD50, resulting in increased 3'-5' exonuclease activity (Dolganov et al. 1996, Paull and Gellert 1998).

Literature References
PubMed ID Title Journal Year
8756642 Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair

Dolganov, GM, Maser, RS, Novikov, A, Tosto, L, Chong, S, Bressan, DA, Petrini, JH

Mol. Cell. Biol. 1996
9651580 The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks

Paull, TT, Gellert, M

Mol Cell 1998
Participants
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Orthologous Events
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