Reactome | cGMP binds CNG channel to form cGMP:CNG channel

cGMP binds CNG channel to form cGMP:CNG channel

Stable Identifier

R-HSA-74031

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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cGMP binds CNG channel to form cGMP:CNG channel

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Once cGMP concentration is restored to "dark" levels, it binds cooperatively to the cGMP-gated cation channel (CNG channel), inducing opening through a conformational change in the channel (open status designated as cGMP:CNG channel here) (Chen et al 1993, Dhallan et al. 1992).

Literature References

PubMed ID	Title	Journal	Year
1379636	Human rod photoreceptor cGMP-gated channel: amino acid sequence, gene structure, and functional expression. Reed, RR, Yau, KW, Nathans, J, Macke, JP, Dhallan, RS, Shows, TB	J Neurosci	1992
7682292	A new subunit of the cyclic nucleotide-gated cation channel in retinal rods Peng, YW, Reed, RR, Yau, KW, Dhallan, RS, Ahamed, B, Chen, TY	Nature	1993