Reactome | TYMS [cytosol]

TYMS [cytosol]

Stable Identifier

R-HSA-73518

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Thymidylate synthase , TS, TSase

Locations in the PathwayBrowser for interactor UniProt:P19320%20VCAM1

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - Mitotic G1 phase and G1/S transition (Homo sapiens)
    - G1/S Transition (Homo sapiens)
      - G1/S-Specific Transcription (Homo sapiens)
        
        TYMS gene expression (Homo sapiens)
        
        TYMS [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P04818 TYMS

Gene Names

TYMS, TS, OK/SW-cl.29

Chain

initiator methionine:, chain:2-313

Reference Genes

BioGPS Gene:7298 TYMS

COSMIC (genes):TYMS TYMS

CTD Gene:7298 TYMS

dbSNP Gene:7298 TYMS

ENSEMBL:ENSG00000176890 TYMS

ENSEMBL_homo_sapiens_GENE:ENSG00000176890.16 TYMS

HGNC:12441 TYMS

KEGG Gene (Homo sapiens):7298 TYMS

Monarch:7298 TYMS

NCBI Gene:7298 TYMS

OMIM:188350 TYMS

UCSC:P04818 TYMS

Reference Transcript

RefSeq:NM_001071.2 TYMS

Other Identifiers

11718058_a_at

11751805_a_at

1505_at

1554696_PM_s_at

1554696_s_at

16850477

202589_PM_at

202589_at

3775843

3775844

3775845

3775846

3775847

3775853

3775855

3775856

3775861

3775862

3775864

3775865

3775866

3775867

3775868

37899_at

7298

8019842

A_23_P50096

D00596_at

GE59639

GO:0000900

GO:0003723

GO:0003729

GO:0003824

GO:0004799

GO:0005542

GO:0005634

GO:0005737

GO:0005739

GO:0005743

GO:0005759

GO:0005829

GO:0006206

GO:0006231

GO:0006235

GO:0006417

GO:0006575

GO:0007623

GO:0008168

GO:0009165

GO:0009410

GO:0009636

GO:0014070

GO:0016020

GO:0016740

GO:0016741

GO:0017148

GO:0019860

GO:0030154

GO:0032259

GO:0032570

GO:0033189

GO:0034097

GO:0035999

GO:0042803

GO:0043226

GO:0045182

GO:0045471

GO:0046653

GO:0046683

GO:0048589

GO:0048856

GO:0051216

GO:0051384

GO:0051593

GO:0055086

GO:0060574

GO:0071897

GO:0097421

GO:1901135

GO:1901363

GO:1990825

HMNXSV003037502

Hs2.432651.1.S1_3p_s_at

ILMN_1806040

PH_hs_0022201

TC18000006.hg

g4507750_3p_at

Participates

as an output of

TYMS gene expression (Homo sapiens)

as a component of

TS dimer [cytosol] (Homo sapiens)

Inferred To

TYMS [cytosol] (Bos taurus)

TYMS [cytosol] (Canis familiaris)

TYMS [cytosol] (Drosophila melanogaster)

TYMS [cytosol] (Mus musculus)

TYMS [cytosol] (Plasmodium falciparum)

TYMS [cytosol] (Rattus norvegicus)

TYMS [cytosol] (Saccharomyces cerevisiae)

TYMS [cytosol] (Schizosaccharomyces pombe)

TYMS [cytosol] (Sus scrofa)

zgc:56465 [cytosol] (Danio rerio)

tyms [cytosol] (Xenopus tropicalis)

tyms-1 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001062.1

ZINC - World Drugs

TYSY_HUMAN

Guide to Pharmacology - Targets

2642

OpenTargets

ENSG00000176890

ZINC - FDA approved

TYSY_HUMAN

ZINC - Substances

TYSY_HUMAN

ZINC target

P04818

ZINC - Biogenic

TYSY_HUMAN

PRO

P04818

PDB

5X5Q, 3GH0, 6OJU, 1I00, 3EAW, 5X4W, 5HS3, 6PF4, 2ONB, 6PF5, 3GH2, 3EHI, 4FGT, 5X67, 6QXH, 4G6W, 3EJL, 5X69, 4UP1, 5X66, 1HVY, 3H9K, 1HW3, 4O1U, 3HB8, 3GG5, 4O1X, 5X5A, 4GD7, 3N5E, 3EBU, 1HW4, 4E28, 2RDA, 3EGY, 3N5G, 5X5D, 3OB7, 1YPV, 4JEF, 6R2E, 4G2O, 6QYQ, 4H1I, 1JU6, 3EDW, 5X4X, 2RD8, 5X4Y, 4KPW, 6PF6, 4GYH, 6OJV, 6QXG, 3ED7, 3EF9, 1JUJ, 5WRN, 6ZXO, 6PF3, 1HZW

ZINC - Investigational

TYSY_HUMAN

ZINC - Metabolites

TYSY_HUMAN

HPA

ENSG00000176890-TYMS

GeneCards

P04818

Ensembl

ENSG00000176890, ENST00000323224, ENST00000323274, ENSP00000315644, ENSP00000314902, ENSP00000314727, ENST00000323250

Pharos - Targets

P04818

ZINC - Predictions - Purchasable

TYSY_HUMAN

Orphanet

19453

HMDB Protein

HMDBP04363

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4