Reactome | RPL15 [cytosol]

RPL15 [cytosol]

Stable Identifier

R-HSA-72416

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

60S ribosomal protein L15, P39030

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to starvation (Homo sapiens)
    - Response of EIF2AK4 (GCN2) to amino acid deficiency (Homo sapiens)
      - EIF2AK4 (GCN2) binds tRNA (Homo sapiens)
        
        EIF2AK4:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL15 [cytosol] (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL15 [cytosol] (Homo sapiens)
      - EIF2AK4 (GCN2) dimer autophosphorylates (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL15 [cytosol] (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL15 [cytosol] (Homo sapiens)
      - IMPACT binds GCN1 (Homo sapiens)
        
        GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL15 [cytosol] (Homo sapiens)
        
        IMPACT:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL15 [cytosol] (Homo sapiens)
      - p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL15 [cytosol] (Homo sapiens)

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Influenza Infection (Homo sapiens)
      - Influenza Viral RNA Transcription and Replication (Homo sapiens)
        
        Viral mRNA Translation (Homo sapiens)
        
        Synthesis of PB1-F2 (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL15 [cytosol] (Homo sapiens)
        
        Viral Protein Synthesis (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL15 [cytosol] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Nonsense-Mediated Decay (NMD) (Homo sapiens)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL15 [cytosol] (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL15 [cytosol] (Homo sapiens)
    - SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL15 [cytosol] (Homo sapiens)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL15 [cytosol] (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL15 [cytosol] (Homo sapiens)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL15 [cytosol] (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL15 [cytosol] (Homo sapiens)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Homo sapiens)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL15 [cytosol] (Homo sapiens)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL15 [cytosol] (Homo sapiens)
- rRNA processing (Homo sapiens)
  - rRNA processing in the nucleus and cytosol (Homo sapiens)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL15 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P61313 RPL15

Gene Names

RPL15, EC45, TCBAP0781

Chain

initiator methionine:, chain:2-204

Reference Genes

BioGPS Gene:6138 RPL15

COSMIC (genes):RPL15 RPL15

CTD Gene:6138 RPL15

dbSNP Gene:6138 RPL15

ENSEMBL:ENSG00000174748 RPL15

ENSEMBL_homo_sapiens_GENE:ENSG00000174748.22 RPL15

HGNC:10306 RPL15

KEGG Gene (Homo sapiens):6138 RPL15

Monarch:6138 RPL15

NCBI Gene:6138 RPL15

OMIM:604174 RPL15

UCSC:P61313 RPL15

Reference Transcript

Other Identifiers

11752951_x_at

11754013_x_at

11757075_s_at

11757782_s_at

11757889_s_at

11761987_at

221475_PM_s_at

221475_s_at

221476_PM_s_at

221476_s_at

240806_PM_at

240806_at

2614121

2614122

2614123

2614125

2614129

2614131

2614132

2614133

2614134

2614135

2614136

2614137

2614138

2614139

2726160

2726166

2726169

2895298

2895299

2895300

32432_f_at

3403757

3682162

48807_at

6138

78690_at

8078270

8116929

87923_at

90906_at

A_14_P120924

A_23_P253200

A_24_P538567

GE79914

GE804794

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0005840

GO:0006412

GO:0022625

GO:0022626

GO:0031672

GO:0043226

GO:0044391

GO:0045296

GO:0045471

GO:1990904

HMNXSV003049689

Hs.134772.0.A1_3p_at

Hs.74267.0.S1_3p_s_at

ILMN_1762747

PH_hs_0008117

PH_hs_0029975

TC03000126.hg

TC03002254.hg

g12006349_3p_a_at

Participates

as a component of

Inferred To

rpl15 [cytosol] (Schizosaccharomyces pombe)

rpl15 [cytosol] (Xenopus tropicalis)

wu:fa92b05 [cytosol] (Danio rerio)

RPL15A [cytosol] (Saccharomyces cerevisiae)

RPL15B [cytosol] (Saccharomyces cerevisiae)

RpL15 [cytosol] (Drosophila melanogaster)

Rpl15 [cytosol] (Mus musculus)

Rpl15 [cytosol] (Rattus norvegicus)

RPL15 [cytosol] (Bos taurus)

RPL15 [cytosol] (Canis familiaris)

RPL15 [cytosol] (Gallus gallus)

RPL15 [cytosol] (Plasmodium falciparum)

RPL15 [cytosol] (Sus scrofa)

Homologues of RPL15 [cytosol] (Saccharomyces cerevisiae)

Homologues of RPL15 [cytosol] (Schizosaccharomyces pombe)

rpl15-2 [cytosol] (Dictyostelium discoideum)

rpl1502 [cytosol] (Schizosaccharomyces pombe)

rpl-15 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001240309.1, NP_002939.2, NP_001240312.1, NP_001240313.1, NP_001240311.1, NP_001240308.1

OpenTargets

ENSG00000174748

GeneCards

P61313

HPA

ENSG00000174748-RPL15

Ensembl

ENSP00000388529, ENSP00000309334, ENSG00000174748, ENSP00000416692, ENST00000307839, ENSP00000493759, ENSP00000483260, ENSP00000346867, ENST00000611050, ENST00000413699, ENST00000456530, ENSP00000398788, ENST00000354811, ENST00000644185, ENST00000415719

PRO

P61313

Pharos - Targets

P61313

Orphanet

22567

PDB

6ZMO, 8FKU, 5AJ0, 8G6J, 8FLF, 6OLF, 6Y57, 8FL6, 8IDT, 6LSR, 7OW7, 6Y0G, 8GLP, 8FLB, 8FKR, 6Y2L, 8FL4, 6IP8, 5T2C, 6OLE, 4UG0, 8FLD, 6XA1, 8A3D, 7XNX, 8IPX, 8FL2, 8FLA, 8FKY, 7XNY, 8G5Y, 8FKV, 8INK, 6Z6M, 6LSS, 8IR1, 6OLI, 8IR3, 8G60, 8G5Z, 8FKW, 8INE, 6IP6, 8FKT, 8INF, 6IP5, 6OLG, 6Y6X, 6Z6L, 5LKS, 7BHP, 8FKZ, 8FKS, 6ZMI, 6QZP, 6OM7, 7F5S, 8FLE, 8FLC, 6LU8, 8IPY, 8FL3, 6LQM, 6W6L, 8FKX, 8FKQ, 8FKP, 6ZME, 6OM0, 6OLZ, 6ZM7, 8IE3, 8IPD, 8IDY, 8FL7, 8G61, 6Z6N, 8FL9, 4V6X

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	16
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	5
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.495	2
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2

Cite Us!