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Formation of pre-mRNPs
Stable Identifier
R-HSA-72103
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
Formation of pre-mRNPs (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
After the nascent pre-mRNA undergoes the initial capping and methylation reactions, it gets associated with numerous factors, including the various heterogeneous nuclear ribonucleoproteins (hnRNPS), the nuclear Cap-Binding Complex, and many splicing factors that make the pre-mRNA a substrate for splicing, 3'-end processing, and in some cases editing.
Literature References
PubMed ID
Title
Journal
Year
8352591
hnRNP proteins and the biogenesis of mRNA
PiƱol-Roma, S
,
Matunis, MJ
,
Burd, CG
,
Dreyfuss, G
Annu. Rev. Biochem.
1993
Participants
Input
Alternative Splicing Factors [nucleoplasm]
(Homo sapiens)
capped, methylated pre-mRNA:CBC Complex [nucleoplasm]
(Homo sapiens)
Output
capped, methylated pre-mRNP:CBC complex [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
Orthologous Events
Formation of pre-mRNPs (Bos taurus)
Formation of pre-mRNPs (Caenorhabditis elegans)
Formation of pre-mRNPs (Canis familiaris)
Formation of pre-mRNPs (Dictyostelium discoideum)
Formation of pre-mRNPs (Drosophila melanogaster)
Formation of pre-mRNPs (Gallus gallus)
Formation of pre-mRNPs (Mus musculus)
Formation of pre-mRNPs (Plasmodium falciparum)
Formation of pre-mRNPs (Rattus norvegicus)
Formation of pre-mRNPs (Saccharomyces cerevisiae)
Formation of pre-mRNPs (Schizosaccharomyces pombe)
Formation of pre-mRNPs (Sus scrofa)
Formation of pre-mRNPs (Xenopus tropicalis)
Created
Krainer, AR (2003-06-05)
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