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SRSF5 [nucleoplasm]
Stable Identifier
R-HSA-72028
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
SRp40, Splicing factor, arginine/serine-rich 5 (Pre-mRNA splicing factor SRP40) (Delayed-early protein HRS), Splicing factor, arginine/serine-rich 5, Pre-mRNA splicing factor SRP40, Delayed-early protein HRS
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA Polymerase II Transcription Termination (Homo sapiens)
Cleavage of mRNA at the 3'-end (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
SRSF5 [nucleoplasm] (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
SRSF5 [nucleoplasm] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
Transport of Mature Transcript to Cytoplasm (Homo sapiens)
Transport of Mature mRNA derived from an Intron-Containing Transcript (Homo sapiens)
Docking of the TAP:EJC Complex with the NPC (Homo sapiens)
NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
capped mRNA:CBC:EJC:TREX (minus DDX39B) [nucleoplasm] (Homo sapiens)
SRSF5 [nucleoplasm] (Homo sapiens)
SRSF5 [nucleoplasm] (Homo sapiens)
NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Homo sapiens)
NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
capped mRNA:CBC:EJC:TREX (minus DDX39B) [nucleoplasm] (Homo sapiens)
SRSF5 [nucleoplasm] (Homo sapiens)
polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
SRSF5 [nucleoplasm] (Homo sapiens)
mRNA 3'-end processing (Homo sapiens)
Cleavage of mRNA at the 3'-end (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
SRSF5 [nucleoplasm] (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
SRSF5 [nucleoplasm] (Homo sapiens)
TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
SRSF5 [nucleoplasm] (Homo sapiens)
Spliced mRNP [nucleoplasm] (Homo sapiens)
SRSF5 [nucleoplasm] (Homo sapiens)
mRNA polyadenylation (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
SRSF5 [nucleoplasm] (Homo sapiens)
polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
SRSF5 [nucleoplasm] (Homo sapiens)
mRNA Splicing (Homo sapiens)
mRNA Splicing - Major Pathway (Homo sapiens)
Cleavage at the 3'-Splice Site and Exon Ligation (Homo sapiens)
Spliced mRNP [nucleoplasm] (Homo sapiens)
SRSF5 [nucleoplasm] (Homo sapiens)
pre-EJC:Spliceosomal C:pre-mRNP:CBC [nucleoplasm] (Homo sapiens)
SRSF5 [nucleoplasm] (Homo sapiens)
Formation of Exon Junction Complex (Homo sapiens)
Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
SRSF5 [nucleoplasm] (Homo sapiens)
pre-EJC:Spliceosomal C:pre-mRNP:CBC [nucleoplasm] (Homo sapiens)
SRSF5 [nucleoplasm] (Homo sapiens)
Formation of an intermediate Spliceosomal C (Bact) complex (Homo sapiens)
Spliceosomal B Complex [nucleoplasm] (Homo sapiens)
SRSF5 [nucleoplasm] (Homo sapiens)
Spliceosomal Intermediate C (Bact) Complex [nucleoplasm] (Homo sapiens)
SRSF5 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal A Complex (Homo sapiens)
Spliceosomal A Complex [nucleoplasm] (Homo sapiens)
SRSF5 [nucleoplasm] (Homo sapiens)
Spliceosomal E Complex [nucleoplasm] (Homo sapiens)
SRSF5 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal B Complex (Homo sapiens)
Spliceosomal A Complex [nucleoplasm] (Homo sapiens)
SRSF5 [nucleoplasm] (Homo sapiens)
Spliceosomal B Complex [nucleoplasm] (Homo sapiens)
SRSF5 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal E complex (Homo sapiens)
SRSF5 [nucleoplasm] (Homo sapiens)
Spliceosomal E Complex [nucleoplasm] (Homo sapiens)
SRSF5 [nucleoplasm] (Homo sapiens)
Formation of the active Spliceosomal C (B*) complex (Homo sapiens)
Spliceosomal Active C (B*) Complex [nucleoplasm] (Homo sapiens)
SRSF5 [nucleoplasm] (Homo sapiens)
Spliceosomal Intermediate C (Bact) Complex [nucleoplasm] (Homo sapiens)
SRSF5 [nucleoplasm] (Homo sapiens)
Lariat Formation and 5'-Splice Site Cleavage (Homo sapiens)
Spliceosomal Active C (B*) Complex [nucleoplasm] (Homo sapiens)
SRSF5 [nucleoplasm] (Homo sapiens)
Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
SRSF5 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13243 SRSF5
Gene Names
SRSF5, HRS, SFRS5, SRP40
Chain
chain:1-272
Reference Genes
BioGPS Gene:6430 SRSF5
COSMIC (genes):SRSF5 SRSF5
CTD Gene:6430 SRSF5
dbSNP Gene:6430 SRSF5
ENSEMBL:ENSG00000100650 SRSF5
HGNC:10787 SRSF5
KEGG Gene (Homo sapiens):6430 SRSF5
Monarch:6430 SRSF5
NCBI Gene:6430 SRSF5
OMIM:600914 SRSF5
UCSC:Q13243 SRSF5
Reference Transcript
RefSeq:NM_001320214.1 SRSF5
RefSeq:NM_001039465.1 SRSF5
RefSeq:NM_006925.4 SRSF5
Other Identifiers
0000520458
11736129_a_at
11736130_x_at
11744492_x_at
11746137_a_at
11747389_a_at
11753802_a_at
11754349_a_at
11756063_x_at
16785869
203380_x_at
212266_s_at
3542208
3542211
3542212
3542213
3542215
3542217
3542219
3542222
3542232
3542234
3542236
3542237
3542238
3542239
3542240
3542241
3542242
3542243
40453_s_at
43484
56523
6430
7975368
91840_at
A0A024R6D8
A_23_P377819
A_33_P3366146
AAA93070
AAA93074
AAB60405
AAC39543
AAH18823
AAH40209
AAP35752
AB451250
AF020307
AK311805
B4DJK0
B4DUA4
BAG34748
BAG70064
BC018823
BC040209
BT007089
BX640605
CAE45711
CAG46964
CAG46979
CCDS32109
CH471061
CR542167
CR542182
EAW81002
EAW81005
EAW81006
ENSG00000100650
ENSP00000377892
ENSP00000451088
ENSP00000451391
ENSP00000452123
ENST00000394366
ENST00000394366.6
ENST00000553521
ENST00000553521.5
ENST00000553635
ENST00000553635.5
ENST00000557154
ENST00000557154.5
EntrezGene:6430
EntrezGene:SRSF5
G3V5K8
g5902077_3p_a_at
GE59067
GO:0000381
GO:0000398
GO:0001889
GO:0003674
GO:0003676
GO:0003723
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005829
GO:0006376
GO:0006397
GO:0006405
GO:0006406
GO:0006810
GO:0006913
GO:0007049
GO:0008150
GO:0008380
GO:0016607
GO:0019899
GO:0022607
GO:0022618
GO:0031124
GO:0032868
GO:0032869
GO:0033120
GO:0034641
GO:0043226
GO:0043422
GO:0045292
GO:0048856
GO:0051726
GO:0065003
GO:0097421
HGNC:10787
HPA043484
HPA056523
Hs.166975.3.S1_3p_a_at
ILMN_1761996
ILMN_2378868
IPR000504
IPR012677
IPR035585
IPR035979
MIM:600914
NM_001039465
NM_001320214
NM_006925
NP_001034554
NP_001307143
NP_008856
PF00076
PH_hs_0010038
SFRS5
SM00360
SRSF5
SRSF5-201
SRSF5-203
SRSF5-205
SRSF5-217
TC14000418.hg
U30826
U30827
U30827_s_at
U30884
UPI00001358C0
UPI0000D4D1E6
XM_005267999
XM_005268000
XM_011537077
XM_017021593
XP_005268056
XP_005268057
XP_011535379
XP_016877082
Participant Of
input
Formation of the Spliceosomal E complex
hasComponent
3' end cleaved, ligated exon containing complex [nucleoplasm]
capped mRNA:CBC:EJC:TREX (minus DDX39B) [nucleoplasm]
polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm]
pre-EJC:Spliceosomal C:pre-mRNP:CBC [nucleoplasm]
Spliced mRNA:CBC:EJC:TREX [nucleoplasm]
Spliced mRNP [nucleoplasm]
Spliceosomal A Complex [nucleoplasm]
Spliceosomal Active C (B*) Complex [nucleoplasm]
Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP:CBC complex [nucleoplasm]
Spliceosomal B Complex [nucleoplasm]
Spliceosomal E Complex [nucleoplasm]
Spliceosomal Intermediate C (Bact) Complex [nucleoplasm]
output
Docking of the TAP:EJC Complex with the NPC
Inferred To
SRSF5 [nucleoplasm] (Bos taurus)
SRSF5 [nucleoplasm] (Caenorhabditis elegans)
SRSF5 [nucleoplasm] (Canis familiaris)
SRSF5 [nucleoplasm] (Danio rerio)
SRSF5 [nucleoplasm] (Dictyostelium discoideum)
SRSF5 [nucleoplasm] (Drosophila melanogaster)
SRSF5 [nucleoplasm] (Gallus gallus)
SRSF5 [nucleoplasm] (Mus musculus)
SRSF5 [nucleoplasm] (Plasmodium falciparum)
SRSF5 [nucleoplasm] (Rattus norvegicus)
SRSF5 [nucleoplasm] (Schizosaccharomyces pombe)
SRSF5 [nucleoplasm] (Sus scrofa)
SRSF5 [nucleoplasm] (Xenopus tropicalis)
Homologues of SRSF5 [nucleoplasm] (Caenorhabditis elegans)
Homologues of SRSF5 [nucleoplasm] (Dictyostelium discoideum)
Homologues of SRSF5 [nucleoplasm] (Plasmodium falciparum)
Cross References
RefSeq
NP_008856.2
,
NP_001307143.1
,
NP_001034554.1
OpenTargets
ENSG00000100650
GeneCards
Q13243
PRO
Q13243
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q92731 ESR2
5
PalmS-ESR2 [plasma membrane]
(R-HSA-9021059)
PalmS-ESR2 [cytosol]
(R-HSA-9020979)
Me-PalmS-ESR2 [plasma membrane]
(R-HSA-9637787)
ESR2 [nucleoplasm]
(R-HSA-446165)
ESR2 [cytosol]
(R-HSA-9020970)
0.527
2
UniProt:Q8NAV1 PRPF38A
1
PRPF38A [nucleoplasm]
(R-HSA-8867897)
0.508
2
UniProt:Q15696 ZRSR2
1
ZRSR2 [nucleoplasm]
(R-HSA-8865914)
0.488
2
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