Reactome | PRPF4 [nucleoplasm]

PRPF4 [nucleoplasm]

Stable Identifier

R-HSA-71890

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

hPrp4, WD splicing factor Prp4, U4/U6 small nuclear ribonucleoprotein Prp4, U4/U6 snRNP 60 kDa protein

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Homo sapiens)

- Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
  - mRNA Splicing (Homo sapiens)
    - mRNA Splicing - Major Pathway (Homo sapiens)
      - Formation of the Spliceosomal B complex (Homo sapiens)
        
        Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
        
        U4:U5:U6 tri-snRNP complex [nucleoplasm] (Homo sapiens)
        
        U4 snRNP:U6 snRNP complex [nucleoplasm] (Homo sapiens)
        
        U4 snRNP [nucleoplasm] (Homo sapiens)
        
        PPIH:PRPF4:PRPF3 [nucleoplasm] (Homo sapiens)
        
        PRPF4 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal Bact complex (Homo sapiens)
        
        U4 snRNP [nucleoplasm] (Homo sapiens)
        
        PPIH:PRPF4:PRPF3 [nucleoplasm] (Homo sapiens)
        
        PRPF4 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal Pre-B complex (Homo sapiens)
        
        Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
        
        U4:U5:U6 tri-snRNP complex [nucleoplasm] (Homo sapiens)
        
        U4 snRNP:U6 snRNP complex [nucleoplasm] (Homo sapiens)
        
        U4 snRNP [nucleoplasm] (Homo sapiens)
        
        PPIH:PRPF4:PRPF3 [nucleoplasm] (Homo sapiens)
        
        PRPF4 [nucleoplasm] (Homo sapiens)
        
        U4:U5:U6 tri-snRNP complex [nucleoplasm] (Homo sapiens)
        
        U4 snRNP:U6 snRNP complex [nucleoplasm] (Homo sapiens)
        
        U4 snRNP [nucleoplasm] (Homo sapiens)
        
        PPIH:PRPF4:PRPF3 [nucleoplasm] (Homo sapiens)
        
        PRPF4 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O43172 PRPF4

Gene Names

PRPF4, PRP4

Chain

chain:1-522

Reference Genes

BioGPS Gene:9128 PRPF4

COSMIC (genes):PRPF4 PRPF4

CTD Gene:9128 PRPF4

dbSNP Gene:9128 PRPF4

ENSEMBL:ENSG00000136875 PRPF4

ENSEMBL_homo_sapiens_GENE:ENSG00000136875.13 PRPF4

HGNC:17349 PRPF4

KEGG Gene (Homo sapiens):9128 PRPF4

Monarch:9128 PRPF4

NCBI Gene:9128 PRPF4

OMIM:607795 PRPF4

UCSC:O43172 PRPF4

Reference Transcript

Other Identifiers

11729594_s_at

11729595_x_at

11759011_at

17088185

209161_PM_at

209161_at

209162_PM_s_at

209162_s_at

3185562

3185563

3185564

3185565

3185566

3185567

3185569

3185570

3185573

3185575

3185576

3185578

3185580

3185582

3185583

3185584

3185585

3185586

3185588

37935_at

37936_at

8157283

9128

A_14_P118862

A_23_P60537

GE54135

GO:0000375

GO:0000398

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005681

GO:0006396

GO:0006397

GO:0008380

GO:0015030

GO:0016071

GO:0016607

GO:0017070

GO:0030621

GO:0043226

GO:0046540

GO:0071001

GO:0071005

GO:0097525

HMNXSV003031976

Hs.8551.0.S2_3p_at

ILMN_1697440

PH_hs_0018186

TC09000573.hg

g2853276_3p_a_at

Participates

as a component of

PPIH:PRPF4:PRPF3 [nucleoplasm] (Homo sapiens)

Inferred To

Prpf4 [nucleoplasm] (Mus musculus)

Prpf4 [nucleoplasm] (Rattus norvegicus)

U4-U6-60K [nucleoplasm] (Drosophila melanogaster)

prp-4 [nucleoplasm] (Caenorhabditis elegans)

PRPF4 [nucleoplasm] (Bos taurus)

PRPF4 [nucleoplasm] (Canis familiaris)

PRPF4 [nucleoplasm] (Gallus gallus)

PRPF4 [nucleoplasm] (Plasmodium falciparum)

PRPF4 [nucleoplasm] (Schizosaccharomyces pombe)

PRPF4 [nucleoplasm] (Sus scrofa)

prpf4 [nucleoplasm] (Dictyostelium discoideum)

prpf4 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_004688.2, NP_001231855.1

ZINC - World Drugs

PRP4_HUMAN

OpenTargets

ENSG00000136875

ZINC - FDA approved

PRP4_HUMAN

ZINC - Substances

PRP4_HUMAN

ZINC target

O43172

PRO

O43172

PDB

6AHD, 1MZW, 6AH0, 6QX9, 5O9Z, 3JCR, 6QW6

HPA

ENSG00000136875-PRPF4

GeneCards

O43172

Ensembl

ENST00000374198, ENSP00000363315, ENSG00000136875, ENSP00000363313, ENST00000374199

Pharos - Targets

O43172

ZINC - Predictions - Purchasable

PRP4_HUMAN

Orphanet

22891

HMDB Protein

HMDBP09500

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q53GS9 USP39	1	USP39 [nucleoplasm] (R-HSA-6806793)	0.564	3
UniProt:O94906 PRPF6	1	PRPF6 [nucleoplasm] (R-HSA-71881)	0.564	2
UniProt:Q9BUQ8 DDX23	1	DDX23 [nucleoplasm] (R-HSA-71879)	0.564	2
UniProt:Q13523 PRPF4B	1	PRPF4B [nucleoplasm] (R-HSA-9769525)	0.564	2
UniProt:O43290 SART1	1	SART1 [nucleoplasm] (R-HSA-4615999)	0.564	2
UniProt:Q92917 GPKOW	1	GPKOW [nucleoplasm] (R-HSA-8850839)	0.508	2