Reactome | EFTUD2 [nucleoplasm]

EFTUD2 [nucleoplasm]

Stable Identifier

R-HSA-71883

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

U5-116 kDa protein, U5S1_HUMAN, 116 kDa U5 small nuclear ribonucleoprotein component (U5 snRNP- specific protein, 116 kDa) (U5-116 kDa), 116 kDa U5 small nuclear ribonucleoprotein component, U5 snRNP- specific protein, 116 kDa, U5-116 kDa

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q15029 EFTUD2

Gene Names

EFTUD2, KIAA0031, SNRP116

Chain

chain:1-972

Reference Genes

BioGPS Gene:9343 EFTUD2

COSMIC (genes):EFTUD2 EFTUD2

CTD Gene:9343 EFTUD2

dbSNP Gene:9343 EFTUD2

ENSEMBL:ENSG00000108883 EFTUD2

ENSEMBL_homo_sapiens_GENE:ENSG00000108883.13 EFTUD2

HGNC:30858 EFTUD2

KEGG Gene (Homo sapiens):9343 EFTUD2

Monarch:9343 EFTUD2

NCBI Gene:9343 EFTUD2

OMIM:603892 EFTUD2

UCSC:Q15029 EFTUD2

Reference Transcript

Other Identifiers

11716057_a_at

11716058_a_at

11716059_x_at

11740353_a_at

11740354_a_at

11758740_at

16845742

222397_PM_at

222397_at

222398_PM_s_at

222398_s_at

3759358

3759359

3759360

3759361

3759362

3759364

3759366

3759368

3759369

3759370

3759371

3759372

3759374

3759377

3759378

3759380

3759382

3759384

3759385

3759389

3759393

3759394

3759396

3759397

3759399

3759400

3759401

3759402

3759403

3759404

3759405

3759406

3759408

3759409

8016099

9343

A_23_P55190

D21163_at

GE57110

GO:0000166

GO:0000398

GO:0003723

GO:0003746

GO:0003824

GO:0003924

GO:0005515

GO:0005525

GO:0005634

GO:0005654

GO:0005681

GO:0005829

GO:0006397

GO:0006414

GO:0008380

GO:0010467

GO:0015030

GO:0016020

GO:0016071

GO:0016607

GO:0016787

GO:0030623

GO:0042220

GO:0043226

GO:0043231

GO:0045182

GO:0046540

GO:0071005

GO:0071007

GO:0071013

GO:0071466

HMNXSV003035382

Hs.151787.0.S3_3p_at

ILMN_1738819

PH_hs_0031865

PH_hs_0038658

TC17001586.hg

g12803112_3p_a_at

Participates

as a component of

Inferred To

Dmel\CG4849 [nucleoplasm] (Drosophila melanogaster)

eftu-2 [nucleoplasm] (Caenorhabditis elegans)

eftud2 [nucleoplasm] (Dictyostelium discoideum)

eftud2 [nucleoplasm] (Xenopus tropicalis)

EFTUD2 [nucleoplasm] (Bos taurus)

EFTUD2 [nucleoplasm] (Canis familiaris)

EFTUD2 [nucleoplasm] (Gallus gallus)

EFTUD2 [nucleoplasm] (Mus musculus)

EFTUD2 [nucleoplasm] (Plasmodium falciparum)

EFTUD2 [nucleoplasm] (Schizosaccharomyces pombe)

EFTUD2 [nucleoplasm] (Sus scrofa)

Eftud2 [nucleoplasm] (Rattus norvegicus)

wu:fi20f05 [nucleoplasm] (Danio rerio)

Cross References

RefSeq

NP_001245282.1, NP_004238.3, NP_001136077.1, NP_001245283.1

OpenTargets

ENSG00000108883

HPA

ENSG00000108883-EFTUD2

GeneCards

Q15029

Ensembl

ENST00000426333, ENST00000591382, ENSP00000467805, ENSG00000108883, ENSP00000465058, ENSP00000385873, ENSP00000392094, ENST00000592576, ENST00000402521

PRO

Q15029

Pharos - Targets

Q15029

Orphanet

20817

HMDB Protein

HMDBP08614

PDB

5Z57, 6ID1, 7AAV, 5Z58, 7W5A, 7W5B, 7QTT, 8C6J, 5O9Z, 6ID0, 5YZG, 5XJC, 6FF4, 5Z56, 6QDV, 6FF7, 7W59, 6AHD, 7ABI, 6QW6, 3JCR, 7DVQ, 8CH6, 6AH0, 7ABG, 6QX9, 7ABF, 6ZYM, 6ICZ, 5MQF

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.677	6
UniProt:O94906 PRPF6	1	PRPF6 [nucleoplasm] (R-HSA-71881)	0.641	3
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.527	2
UniProt:Q13123 IK	1	IK [nucleoplasm] (R-HSA-9770239)	0.508	2
UniProt:Q00613 HSF1	11	p-S121-HSF1 [cytosol] (R-HSA-4793906) p-S303-HSF1 [cytosol] (R-HSA-4793927) p-S307-HSF1 [cytosol] (R-HSA-4793929) p-S303,307-HSF1 [cytosol] (R-HSA-4793922) HSF1 [nucleoplasm] (R-HSA-5082385) hC36,103-HSF1 [cytosol] (R-HSA-4793916) p-S230-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082361) p-S326-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082355) Ac-K80-hC36,103-HSF1 [nucleoplasm] (R-HSA-5097238) hC36,103-HSF1 [nucleoplasm] (R-HSA-3371416) HSF1 [cytosol] (R-HSA-3371452)	0.508	2
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.508	2
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.504	4
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	6