GPI dimer isomerizes Fru(6)P to G6P

Stable Identifier
R-HSA-70475
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
beta-D-fructose 6-phosphate => alpha-D-glucose 6-phosphate
ReviewStatus
5/5
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The reversible isomerization of Fru(6)P (fructose-6-phosphate) to form G6P (glucose-6-phosphate) is catalyzed by cytosolic GPI (phosphoglucose isomerase) dimer (Noltman 1972; Tsuboi et al. 1958; Xu and Beutler 1994).
Literature References
PubMed ID Title Journal Year
7989588 The characterization of gene mutations for human glucose phosphate isomerase deficiency associated with chronic hemolytic anemia

Beutler, E, Xu, W

J Clin Invest 1994
13538944 Enzymes of the human erythrocyte. IV. Phosphoglucose isomerase, purification and properties.

Tsuboi, KK, Hudson, PB, Estrada, J

J Biol Chem 1958
  The Enzymes, 3rd ed

Boyer, PD

  1972
Participants
Output
Participates
Catalyst Activity

glucose-6-phosphate isomerase activity of GPI dimer [cytosol]

Orthologous Events
Cross References
Rhea
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Reviewed
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