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Lipo-K110-DLST [mitochondrial matrix]
Stable Identifier
R-HSA-69993
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
alpha-ketoglutarate dehydrogenase E2, DLST, Dihydrolipoamide succinyltransferase
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Glyoxylate metabolism and glycine degradation (Homo sapiens)
LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Homo sapiens)
lipoylated DHs [mitochondrial matrix] (Homo sapiens)
lipo-aKGDH [mitochondrial matrix] (Homo sapiens)
lipo-aKGDH E2 [mitochondrial matrix] (Homo sapiens)
Lipo-K110-DLST [mitochondrial matrix] (Homo sapiens)
Lysine catabolism (Homo sapiens)
alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Homo sapiens)
lipo-aKGDH [mitochondrial matrix] (Homo sapiens)
lipo-aKGDH E2 [mitochondrial matrix] (Homo sapiens)
Lipo-K110-DLST [mitochondrial matrix] (Homo sapiens)
The citric acid (TCA) cycle and respiratory electron transport (Homo sapiens)
Pyruvate metabolism and Citric Acid (TCA) cycle (Homo sapiens)
Citric acid cycle (TCA cycle) (Homo sapiens)
alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Homo sapiens)
lipo-aKGDH [mitochondrial matrix] (Homo sapiens)
lipo-aKGDH E2 [mitochondrial matrix] (Homo sapiens)
Lipo-K110-DLST [mitochondrial matrix] (Homo sapiens)
External Reference Information
External Reference
UniProt:P36957 DLST
Gene Names
DLST, DLTS
Chain
transit peptide:1-67, chain:68-453
Reference Genes
BioGPS Gene:1743 DLST
COSMIC (genes):DLST DLST
CTD Gene:1743 DLST
dbSNP Gene:1743 DLST
ENSEMBL:ENSG00000119689 DLST
HGNC:2911 DLST
KEGG Gene (Homo sapiens):1743 DLST
Monarch:1743 DLST
NCBI Gene:1743 DLST
OMIM:126063 DLST
UCSC:P36957 DLST
Reference Transcript
RefSeq:NM_001933.4 DLST
Other Identifiers
0000730347
00020+2.3.1.61
00310+2.3.1.61
00380+2.3.1.61
11720929_a_at
11720930_s_at
11720931_x_at
11720932_s_at
11748080_a_at
11751226_x_at
16786524
1743
215210_s_at
2418675
2418678
2418682
2418684
3010
33257_at
33258_g_at
3544351
3544352
3544353
3544354
3544355
3544356
3544358
3544360
3544363
3544364
3544365
3544367
3544369
3544370
3544372
3544373
3544374
3544375
3544376
3544377
3544378
3544379
3544380
3544381
45545_at
7975747
A0A024R6C9
A_14_P109426
A_24_P13572
AAB59629
AAD30181
AAH00302
AAH01922
AC006530
AK289414
AK299505
B7ZAZ8
BAA03871
BAA05536
BAF82103
BAH13054
BC000302
BC001922
CCDS9833
CH471061
D16373
D26535
D26535_s_at
DLST
DLST-202
EAW81199
EAW81202
ENSG00000119689
ENSP00000335304
ENST00000334220
ENST00000334220.8
EntrezGene:1743
EntrezGene:DLST
G3V3F0
G3V498
G3V5L9
G3V5M3
GE61495
GO:0003674
GO:0004149
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005737
GO:0005739
GO:0005759
GO:0006091
GO:0006099
GO:0006103
GO:0006104
GO:0006464
GO:0006520
GO:0006554
GO:0006790
GO:0008150
GO:0009056
GO:0016020
GO:0016740
GO:0016746
GO:0032991
GO:0033512
GO:0034641
GO:0043226
GO:0044281
GO:0045252
GO:0051186
GO:0106077
HGNC:2911
HPA003010
Hs.296348.0.S1_3p_s_at
ILMN_1773228
IPR000089
IPR001078
IPR003016
IPR006255
IPR011053
IPR023213
L37418
MIM:126063
MIM:618475
NM_001933
NP_001924
NR_045209
PF00198
PF00364
PH_hs_0029663
PH_hs_0032549
Q86SW4
TC14000465.hg
TC14001772.hg
UPI00000000C0
XR_001750184
Participant Of
hasComponent
lipo-aKGDH E2 [mitochondrial matrix]
Other forms of this molecule
DLST [mitochondrial matrix]
Inferred To
Lipo-K110-DLST [mitochondrial matrix] (Caenorhabditis elegans)
Lipo-K110-DLST [mitochondrial matrix] (Danio rerio)
Lipo-K110-DLST [mitochondrial matrix] (Dictyostelium discoideum)
Lipo-K110-DLST [mitochondrial matrix] (Drosophila melanogaster)
Lipo-K110-DLST [mitochondrial matrix] (Gallus gallus)
Lipo-K110-DLST [mitochondrial matrix] (Mus musculus)
Lipo-K110-DLST [mitochondrial matrix] (Plasmodium falciparum)
Lipo-K110-DLST [mitochondrial matrix] (Rattus norvegicus)
Lipo-K110-DLST [mitochondrial matrix] (Saccharomyces cerevisiae)
Lipo-K110-DLST [mitochondrial matrix] (Schizosaccharomyces pombe)
Lipo-K110-DLST [mitochondrial matrix] (Sus scrofa)
Lipo-K110-DLST [mitochondrial matrix] (Xenopus tropicalis)
Modified Residues
Name
N6-lipoyl-L-lysine at 110
Coordinate
110
PsiMod Name
N6-lipoyl-L-lysine [MOD:00127]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-lipoyl-L-lysine.
Cross References
RefSeq
NP_001924.2
OpenTargets
ENSG00000119689
IntEnz
2.3.1.61
GeneCards
P36957
PRO
P36957
HMDB Protein
HMDBP00939
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.499
4
UniProt:P06493 CDK1
10
CDK1 [nucleoplasm]
(R-HSA-68889)
CDK1 [endoplasmic reticulum membrane]
(R-HSA-264424)
CDK1 [cytosol]
(R-HSA-170075)
p-T161-CDK1 [nucleoplasm]
(R-HSA-170066)
p-T161-CDK1 [cytosol]
(R-HSA-157415)
p-T14,Y15,T161-CDK1 [cytosol]
(R-HSA-170071)
p-T14-CDK1 [cytosol]
(R-HSA-170064)
p-T14,T161-CDK1 [nucleoplasm]
(R-HSA-170078)
p-T14,Y15,T161-CDK1 [nucleoplasm]
(R-HSA-170074)
p-T14-CDK1 [nucleoplasm]
(R-HSA-170045)
0.499
3
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