Inactivation of Cyclin E:Cdk2 complexes by p27/p21

Stable Identifier
R-HSA-69562
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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During G1, the activity of cyclin-dependent kinases (CDKs) is controlled by the CDK inhibitors (CKIs) CDKN1A (p21) and CDKN1B (p27), thereby preventing premature entry into S phase (see Guardavaccaro and Pagano, 2006). The efficient recognition and ubiquitination of p27 by the SCF (Skp2) complex requires the formation of a trimeric complex containing p27 and cyclin E/A:Cdk2.

Literature References
PubMed ID Title Journal Year
8242751 The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.

Harper, JW, Adami, GR, Wei, N, Keyomarsi, K, Elledge, SJ

Cell 1993
10323868 Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation

Montagnoli, A, Fiore, F, Eytan, E, Carrano, AC, Draetta, GF, Hershko, A, Pagano, M

Genes Dev 1999
16262255 Ubiquitination of p21Cip1/WAF1 by SCFSkp2: substrate requirement and ubiquitination site selection

Wang, W, Nacusi, L, Sheaff, RJ, Liu, X

Biochemistry 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cyclin-dependent protein serine/threonine kinase inhibitor activity of CDKN1A,CDKN1B [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Reviewed
Created