G2/M Transition

Stable Identifier
R-HSA-69275
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Together with two B-type cyclins, CCNB1 and CCNB2, Cdc2 (CDK1) regulates the transition from G2 into mitosis. CDK1 can also form complexes with Cyclin A (CCNA1 and CCNA3). CDK1 complexes with A and B type cyclins are activated by dephosphorylation of CDK1 threonine residue T14 and tyrosine residue Y15. Cyclin A:CDK1 and Cyclin B:CDK1 complexes phosphorylate several proteins involved in mitotic spindle formation and function, the breakdown of the nuclear envelope, and chromosome condensation that is necessary for the ~2 meters of DNA to be segregated at mitosis (Nigg 1998, Nilsson and Hoffmann 2000, Salaun et al. 2008, Fisher et al. 2012).

Literature References
PubMed ID Title Journal Year
18497029 Cdk1, Plks, Auroras, and Neks: the mitotic bodyguards

Salaun, P, Rannou, Y, Prigent, C

Adv. Exp. Med. Biol. 2008
9914175 Polo-like kinases: positive regulators of cell division from start to finish

Nigg, EA

Curr. Opin. Cell Biol. 1998
10740819 Cell cycle regulation by the Cdc25 phosphatase family

Nilsson, I, Hoffmann, I

Prog Cell Cycle Res 2000
23223895 Phosphorylation network dynamics in the control of cell cycle transitions

Fisher, D, Krasinska, L, Coudreuse, D, Novák, B

J. Cell. Sci. 2012
Participants
Participant Of
Event Information
Orthologous Events
Reviewed