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PSMC1 [cytosol]
Stable Identifier
R-HSA-68768
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
26S protease regulatory subunit 4, P26s4
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
G1/S DNA Damage Checkpoints (Homo sapiens)
p53-Dependent G1/S DNA damage checkpoint (Homo sapiens)
p53-Dependent G1 DNA Damage Response (Homo sapiens)
Stabilization of p53 (Homo sapiens)
Autodegradation of the E3 ubiquitin ligase COP1 (Homo sapiens)
Proteasome mediated degradation of COP1 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
p53-Independent G1/S DNA damage checkpoint (Homo sapiens)
p53-Independent DNA Damage Response (Homo sapiens)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Homo sapiens)
Proteolytic degradation of ubiquitinated-Cdc25A (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
G2/M Checkpoints (Homo sapiens)
GTSE1 facilitates proteasome-mediated degradation of TP53 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Separation of Sister Chromatids (Homo sapiens)
Degradation of multiubiquitinated Securin (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
Mitotic G2-G2/M phases (Homo sapiens)
G2/M Transition (Homo sapiens)
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis (Homo sapiens)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
Proteasome-mediated degradation of PolyUb-FBXL7 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
The role of GTSE1 in G2/M progression after G2 checkpoint (Homo sapiens)
GTSE1 facilitates proteasome-mediated degradation of TP53 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
Degradation of multiubiquitinated cell cycle proteins (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
APC/C:Cdc20 mediated degradation of Securin (Homo sapiens)
Degradation of multiubiquitinated Securin (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Homo sapiens)
Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Homo sapiens)
Degradation multiubiquitinated Cyclin A (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
Regulation of APC/C activators between G1/S and early anaphase (Homo sapiens)
SCF-beta-TrCP mediated degradation of Emi1 (Homo sapiens)
SCF-mediated degradation of Emi1 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
S Phase (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
CDK-mediated phosphorylation and removal of Cdc6 (Homo sapiens)
Ubiquitinated Cdc6 is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
Orc1 removal from chromatin (Homo sapiens)
Ubiquitinated Orc1 is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
Ubiquitin-dependent degradation of Cyclin D (Homo sapiens)
Proteasome mediated degradation of Cyclin D1 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
26S proteasome degrades Ub-NFE2L2 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
ub UBXN7 is degraded by the 26S proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
Cellular response to hypoxia (Homo sapiens)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Homo sapiens)
Proteasome proteolyzes ub-HIF-alpha (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
DNA Replication (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
CDK-mediated phosphorylation and removal of Cdc6 (Homo sapiens)
Ubiquitinated Cdc6 is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
Orc1 removal from chromatin (Homo sapiens)
Ubiquitinated Orc1 is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
Regulation of expression of SLITs and ROBOs (Homo sapiens)
Proteasome degrades ubiquitinated ROBO3.1 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Hh mutants abrogate ligand secretion (Homo sapiens)
Hh mutants are degraded by ERAD (Homo sapiens)
processing defective Hh variants are degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
Disorders of transmembrane transporters (Homo sapiens)
ABC transporter disorders (Homo sapiens)
Defective CFTR causes cystic fibrosis (Homo sapiens)
CFTR F508del is degraded by the 26S proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HIV Infection (Homo sapiens)
Host Interactions of HIV factors (Homo sapiens)
Vif-mediated degradation of APOBEC3G (Homo sapiens)
Proteosome-mediated degradation of APOBEC3G (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
Vpu mediated degradation of CD4 (Homo sapiens)
Degradation of ubiquitinated CD4 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 regulates transcription of genes involved in differentiation of HSCs (Homo sapiens)
26S proteasome degrades TP73 polyubiquitinated by ITCH (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
Proteasome degrades PolyUb-RUNX2 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
Proteasome degrades polyubiquitinated RUNX2 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing-Cross presentation (Homo sapiens)
Cross-presentation of soluble exogenous antigens (endosomes) (Homo sapiens)
Proteasomal clevage of exogenous antigen (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
ER-Phagosome pathway (Homo sapiens)
Proteasomal cleavage of substrate (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Proteasomal cleavage of substrate (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Downstream signaling events of B Cell Receptor (BCR) (Homo sapiens)
Activation of NF-kappaB in B cells (Homo sapiens)
Ubiquitinated IkB is degraded (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
TCR signaling (Homo sapiens)
Downstream TCR signaling (Homo sapiens)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
TNFR2 non-canonical NF-kB pathway (Homo sapiens)
26Sproteasome degrades K48polyUb-NIK (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
NIK-->noncanonical NF-kB signaling (Homo sapiens)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
Protesomal degradation of K48polyUb-TRAF3 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
Dectin-1 mediated noncanonical NF-kB signaling (Homo sapiens)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated NF-kB activation (Homo sapiens)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Metabolism of polyamines (Homo sapiens)
Regulation of ornithine decarboxylase (ODC) (Homo sapiens)
26S proteosome degrades ODC holoenzyme complex (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Regulation of mRNA stability by proteins that bind AU-rich elements (Homo sapiens)
AUF1 (hnRNP D0) binds and destabilizes mRNA (Homo sapiens)
AUF1:mRNA complex is destroyed (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
N-glycan trimming in the ER and Calnexin/Calreticulin cycle (Homo sapiens)
Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Homo sapiens)
Deglycosylation complex [endoplasmic reticulum membrane] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
Deubiquitination (Homo sapiens)
UCH proteinases (Homo sapiens)
ADRM1 binds 26S proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
ADRM1:26S proteasome [cytosol] (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
ADRM1:26S proteaseome binds UCHL5 (Homo sapiens)
ADRM1:26S proteasome [cytosol] (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
ADRM1:26S proteasome:UCHL5 [cytosol] (Homo sapiens)
ADRM1:26S proteasome [cytosol] (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
Ub-specific processing proteases (Homo sapiens)
ADRM1:26S proteaseome binds USP14 (Homo sapiens)
ADRM1:26S proteasome [cytosol] (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
ADRM1:26S proteasome:USP14 [cytosol] (Homo sapiens)
ADRM1:26S proteasome [cytosol] (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
Neddylation (Homo sapiens)
26S proteasome degrades HIFalpha (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
26S proteasome degrades Ub-NFE2L2 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
NEDD8,UBD:NUB1:26S proteasome [cytosol] (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
NEDD8 and UBD bind NUB1 and the 26S proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
NEDD8,UBD:NUB1:26S proteasome [cytosol] (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
ub UBXN7 is degraded by the 26S proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
PTEN Regulation (Homo sapiens)
Regulation of PTEN stability and activity (Homo sapiens)
Proteasome degrades polyubiquitinated PTEN (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
Regulation of RAS by GAPs (Homo sapiens)
NF1 is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
MAPK6/MAPK4 signaling (Homo sapiens)
MAPK6 is degraded by the 26S proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'off' state (Homo sapiens)
Degradation of GLI1 by the proteasome (Homo sapiens)
GLI1 is degraded by the proteasome after ubiquitination by ITCH (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
Degradation of GLI2 by the proteasome (Homo sapiens)
GLI2 is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
GLI3 is processed to GLI3R by the proteasome (Homo sapiens)
GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
ub-GLI is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
Hedgehog ligand biogenesis (Homo sapiens)
Hh C-terminal fragments are degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
PCP/CE pathway (Homo sapiens)
Asymmetric localization of PCP proteins (Homo sapiens)
PRICKLE1 is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
Degradation of beta-catenin by the destruction complex (Homo sapiens)
Degradation of ubiquitinated beta catenin by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Degradation of AXIN (Homo sapiens)
Ub-RibC-AXIN is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
Ubiquitinated AXIN is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
Degradation of DVL (Homo sapiens)
Ubiquitinated DVL is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
Ubiquitinated DVL1 is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
Transport of small molecules (Homo sapiens)
ABC-family proteins mediated transport (Homo sapiens)
misfolded CFTR is degraded by the 26S proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
PSMC1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P62191 PSMC1
Gene Names
PSMC1
Chain
initiator methionine:, chain:2-440
Reference Genes
BioGPS Gene:5700 PSMC1
COSMIC (genes):PSMC1 PSMC1
CTD Gene:5700 PSMC1
dbSNP Gene:5700 PSMC1
ENSEMBL:ENSG00000100764 PSMC1
ENSEMBL_homo_sapiens_GENE:ENSG00000100764.14 PSMC1
HGNC:9547 PSMC1
KEGG Gene (Homo sapiens):5700 PSMC1
Monarch:5700 PSMC1
NCBI Gene:5700 PSMC1
OMIM:602706 PSMC1
UCSC:P62191 PSMC1
Reference Transcript
RefSeq:XM_017021470.1 PSMC1
RefSeq:NM_002802.2 PSMC1
RefSeq:NM_001330212.1 PSMC1
Other Identifiers
11716545_x_at
11748303_x_at
16787409
204219_3p_s_at
204219_PM_s_at
204219_s_at
2471205
2471210
2628584
2628585
2628586
2628587
2628588
2628589
2628590
2628591
2628592
2628593
2703461
2822886
2822887
2822888
2869838
3026199
3406993
3406995
3406997
3407003
3407007
3548281
3548286
3548287
3548288
3548290
3548291
3548292
3548295
3548299
3548301
3548303
3548307
3548308
3548310
3548312
3548314
3548316
3548317
3548318
3548320
3548322
3548324
5700
688_at
7976189
8080923
A_24_P347488
A_32_P57870
A_32_P9700
GE61348
GO:0000166
GO:0000502
GO:0003723
GO:0003824
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005838
GO:0008540
GO:0016020
GO:0016787
GO:0016887
GO:0022624
GO:0030163
GO:0036402
GO:0043161
GO:0043226
GO:0140657
GO:1901800
HMNXSV003052549
ILMN_1710406
ILMN_1721659
ILMN_1736353
L02426_at
PH_hs_0032853
TC14000552.hg
g4506206_3p_a_at
g4506206_3p_s_at
Participates
as a component of
Deglycosylation complex [endoplasmic reticulum membrane] (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
Other forms of this molecule
PSMC1 [nucleoplasm]
Inferred To
Homologues of PSMC1 [cytosol]
(Danio rerio)
PSMC1 [cytosol]
(Bos taurus)
PSMC1 [cytosol]
(Caenorhabditis elegans)
PSMC1 [cytosol]
(Canis familiaris)
PSMC1 [cytosol]
(Dictyostelium discoideum)
PSMC1 [cytosol]
(Drosophila melanogaster)
PSMC1 [cytosol]
(Gallus gallus)
PSMC1 [cytosol]
(Mus musculus)
PSMC1 [cytosol]
(Plasmodium falciparum)
PSMC1 [cytosol]
(Rattus norvegicus)
PSMC1 [cytosol]
(Saccharomyces cerevisiae)
PSMC1 [cytosol]
(Schizosaccharomyces pombe)
PSMC1 [cytosol]
(Sus scrofa)
wu:fj14c10 [cytosol]
(Danio rerio)
wu:fb05d04 [cytosol]
(Danio rerio)
psmc1 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_002793.2
,
XP_016876959.1
,
NP_001317141.1
OpenTargets
ENSG00000100764
GeneCards
P62191
HPA
ENSG00000100764-PSMC1
Ensembl
ENST00000543772
,
ENSP00000445147
,
ENSG00000100764
,
ENSP00000261303
,
ENST00000261303
PRO
P62191
Pharos - Targets
P62191
PDB
7W37
,
7QY7
,
6MSK
,
5VHN
,
7W38
,
5LN3
,
5VFS
,
5M32
,
5VHO
,
5L4G
,
5VHJ
,
5VFQ
,
5T0J
,
7QXX
,
7W3M
,
5VHM
,
7W3A
,
5VHQ
,
5VHR
,
7W3B
,
6MSH
,
5VHI
,
7QXU
,
6MSG
,
6MSB
,
5T0C
,
5VHF
,
5VHP
,
6MSD
,
5T0G
,
7QYB
,
5VHH
,
6WJN
,
5VGZ
,
7W3G
,
8CVT
,
7W3F
,
5VFT
,
7QXW
,
6WJD
,
5VHS
,
6MSJ
,
5VFR
,
7W3C
,
7W3K
,
7QXP
,
5T0H
,
7W3J
,
5VFP
,
5T0I
,
7QXN
,
7W3I
,
7W39
,
5GJQ
,
7QYA
,
7W3H
,
5VFU
,
5GJR
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62333 PSMC6
2
PSMC6 [nucleoplasm]
(R-HSA-174319)
PSMC6 [cytosol]
(R-HSA-68783)
0.825
7
UniProt:Q9Y5K5 UCHL5
2
UCHL5 [cytosol]
(R-HSA-1629778)
UCHL5 [nucleoplasm]
(R-HSA-5689584)
0.669
4
UniProt:P00441 SOD1
5
SOD1 [extracellular region]
(R-HSA-350705)
2xHC-SOD1 [mitochondrial intermembrane space]
(R-HSA-3777108)
SOD1 [mitochondrial intermembrane space]
(R-HSA-3777082)
SOD1 [cytosol]
(R-HSA-350697)
2xHC-SOD1 [cytosol]
(R-HSA-3299726)
0.666
5
UniProt:Q16186 ADRM1
1
ADRM1 [cytosol]
(R-HSA-5665939)
0.643
4
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.643
5
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.615
16
UniProt:Q9Y4K3 TRAF6
8
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
TRAF6 [endosome membrane]
(R-HSA-450272)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
0.589
2
UniProt:O00487 PSMD14
5
PSMD14 [secretory granule lumen]
(R-HSA-6800926)
PSMD14 [extracellular region]
(R-HSA-6806511)
PSMD14 [ficolin-1-rich granule lumen]
(R-HSA-6800419)
PSMD14 [nucleoplasm]
(R-HSA-174329)
PSMD14 [cytosol]
(R-HSA-68722)
0.564
3
UniProt:P54578 USP14
1
USP14 [cytosol]
(R-HSA-5689541)
0.564
2
UniProt:P37840 SNCA
5
SNCA A30P [cytosol]
(R-HSA-5658569)
SNCA [extracellular region]
(R-HSA-976954)
Ub-SNCA [cytosol]
(R-HSA-5660754)
p-S129-SNCA [cytosol]
(R-HSA-9836432)
SNCA [cytosol]
(R-HSA-5658500)
0.556
3
UniProt:P55072 VCP
8
Me3K315-VCP [cytosol]
(R-HSA-8932209)
VCP [endoplasmic reticulum membrane]
(R-HSA-8943105)
VCP [nucleoplasm]
(R-HSA-5643745)
VCP [azurophil granule lumen]
(R-HSA-6800438)
VCP [secretory granule lumen]
(R-HSA-6801039)
VCP [extracellular region]
(R-HSA-6806191)
VCP [ficolin-1-rich granule lumen]
(R-HSA-6800425)
VCP [cytosol]
(R-HSA-1181251)
0.556
3
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.527
2
UniProt:P03372 ESR1
8
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.527
3
UniProt:O60341 KDM1A
1
KDM1A [nucleoplasm]
(R-HSA-996769)
0.508
2
UniProt:O43463 SUV39H1
1
SUV39H1 [nucleoplasm]
(R-HSA-427517)
0.508
2
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