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DNA2 [nucleoplasm]
Stable Identifier
R-HSA-68465
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
dna2 endonuclease, DNA2-like homolog, DNA replication helicase-like homolog
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
G2/M Checkpoints (Homo sapiens)
G2/M DNA damage checkpoint (Homo sapiens)
ATR phosphorylates TP53 (Homo sapiens)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
S Phase (Homo sapiens)
Synthesis of DNA (Homo sapiens)
DNA strand elongation (Homo sapiens)
Lagging Strand Synthesis (Homo sapiens)
Processive synthesis on the lagging strand (Homo sapiens)
Removal of the Flap Intermediate (Homo sapiens)
Recruitment of Dna2 endonuclease (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer:dna2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
Removal of RNA primer and dissociation of RPA and Dna2 (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer:dna2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
Chromosome Maintenance (Homo sapiens)
Telomere Maintenance (Homo sapiens)
Extension of Telomeres (Homo sapiens)
Telomere C-strand (Lagging Strand) Synthesis (Homo sapiens)
Processive synthesis on the C-strand of the telomere (Homo sapiens)
Removal of the Flap Intermediate from the C-strand (Homo sapiens)
Recruitment of DNA2 endonuclease to the C strand (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer:DNA2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer:DNA2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
Homology Directed Repair (Homo sapiens)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
HDR through Homologous Recombination (HRR) (Homo sapiens)
D-loop extension by DNA polymerases (Homo sapiens)
D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
Homologous DNA Pairing and Strand Exchange (Homo sapiens)
CX3 complex binds D-loop structures (Homo sapiens)
D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
D-loop formation mediated by PALB2, BRCA2 and RAD51 (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1:BCDX2 complex [nucleoplasm] (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
Presynaptic phase of homologous DNA pairing and strand exchange (Homo sapiens)
BCDX2 complex stabilizes RAD51 filament (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1:BCDX2 complex [nucleoplasm] (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
RAD51 binds BRCA2 at resected DNA DSBs (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
Resolution of D-Loop Structures (Homo sapiens)
Resolution of D-loop Structures through Holliday Junction Intermediates (Homo sapiens)
BLM mediates dissolution of double Holliday junction (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:FIRRM:FIGNL1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Homo sapiens)
Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
Ligation of DNA and formation of Holliday structures following repair synthesis (Homo sapiens)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
MUS81:EME1,EME2 cleaves D-loop (Homo sapiens)
Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 (Homo sapiens)
Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Homo sapiens)
Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) (Homo sapiens)
D-loop dissociation and strand annealing (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
HDR through Single Strand Annealing (SSA) (Homo sapiens)
Association of RAD51 with RAD52:DNA double-strand break ends (Homo sapiens)
RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
Association of RAD52 with the RPA complex at resected DNA DSBs (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
ERCC1:XPF cleaves flaps generated by SSA (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
RAD52 promotes single strand annealing at resected DNA DSBs (Homo sapiens)
RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
Processing of DNA double-strand break ends (Homo sapiens)
ATR activation at DNA DSBs (Homo sapiens)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
ATR phosphorylates RPA2 (Homo sapiens)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
Activation of CHEK1 at resected DNA DSBs (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
Association of RPA complexes with ssDNA at resected DNA DSBs (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
Binding of ATR:ATRIP to RPA at resected DNA DSBs (Homo sapiens)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
CHEK1 is recruited to resected DNA DSBs (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Homo sapiens)
3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
Long-range resection of DNA DSBs by EXO1 or DNA2 (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
Synthesis of DNA (Homo sapiens)
DNA strand elongation (Homo sapiens)
Lagging Strand Synthesis (Homo sapiens)
Processive synthesis on the lagging strand (Homo sapiens)
Removal of the Flap Intermediate (Homo sapiens)
Recruitment of Dna2 endonuclease (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer:dna2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
Removal of RNA primer and dissociation of RPA and Dna2 (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer:dna2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Diseases of DNA repair (Homo sapiens)
Diseases of DNA Double-Strand Break Repair (Homo sapiens)
Defective homologous recombination repair (HRR) due to BRCA1 loss of function (Homo sapiens)
Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of BRCA1 in PALB2 binding (Homo sapiens)
Defective 3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:BCDX2 complex [nucleoplasm] (Homo sapiens)
Defective 3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
Defective homologous recombination repair (HRR) due to BRCA2 loss of function (Homo sapiens)
Impaired BRCA2 binding to PALB2 (Homo sapiens)
Defective recruitment of BRCA2 and RAD51 due to loss of BRCA2 function in PALB2 binding (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:BRCA2 mutants (PALB2 binding):SEM1:BCDX2 complex [nucleoplasm] (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:BRCA2 mutants (PALB2 binding):SEM1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
Impaired BRCA2 binding to RAD51 (Homo sapiens)
BRCA2 mutants with BRC defects or a defect in the C-terminal RAD51 binding site do not bind RAD51 (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
Defective homologous recombination repair (HRR) due to PALB2 loss of function (Homo sapiens)
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function (Homo sapiens)
Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in BRCA1 binding (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1:BCDX2 complex [nucleoplasm] (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function (Homo sapiens)
Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in binding to BRCA2/RAD51/RAD51C (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1:BCDX2 complex [nucleoplasm] (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
ATR phosphorylates TP53 (Homo sapiens)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P51530 DNA2
Gene Names
DNA2, DNA2L, KIAA0083
Chain
chain:1-1060
Reference Genes
BioGPS Gene:1763 DNA2
COSMIC (genes):DNA2 DNA2
CTD Gene:1763 DNA2
dbSNP Gene:1763 DNA2
ENSEMBL:ENSG00000138346 DNA2
ENSEMBL_homo_sapiens_GENE:ENSG00000138346.16 DNA2
HGNC:2939 DNA2
KEGG Gene (Homo sapiens):1763 DNA2
Monarch:1763 DNA2
NCBI Gene:1763 DNA2
OMIM:601810 DNA2
UCSC:P51530 DNA2
Reference Transcript
RefSeq:NM_001080449.2 DNA2
Other Identifiers
11752058_a_at
11755807_a_at
16714998
1763
213647_PM_at
213647_at
3292693
3292697
3292698
3292699
3292701
3292702
3292704
3292706
3292707
3292708
3292709
3292710
3292714
3292715
3292716
3292717
3292718
3292719
3292721
3292722
3292725
3292726
3292727
3292729
3292730
3292731
3292732
38885_at
7934026
A_33_P3833211
D42046_at
GE63205
GO:0000076
GO:0000166
GO:0000278
GO:0000723
GO:0000729
GO:0000781
GO:0003677
GO:0003678
GO:0003723
GO:0003824
GO:0004386
GO:0004518
GO:0004519
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005739
GO:0005760
GO:0006259
GO:0006260
GO:0006264
GO:0006281
GO:0006284
GO:0006974
GO:0007005
GO:0008152
GO:0016787
GO:0016887
GO:0016890
GO:0017108
GO:0017116
GO:0023052
GO:0032200
GO:0032201
GO:0032508
GO:0033567
GO:0042645
GO:0043137
GO:0043139
GO:0043226
GO:0043504
GO:0044806
GO:0045740
GO:0046872
GO:0051536
GO:0051539
GO:0071932
GO:0090305
GO:0090656
GO:0140097
GO:0140657
GO:1902990
HMNXSV003015016
Hs.194665.0.A1_3p_at
ILMN_1664682
ILMN_2282959
PH_hs_0011494
TC10001347.hg
TC10002686.hg
Participates
as an input of
Recruitment of Dna2 endonuclease (Homo sapiens)
Recruitment of DNA2 endonuclease to the C strand (Homo sapiens)
as an output of
Removal of RNA primer and dissociation of RPA and Dna2 (Homo sapiens)
Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Homo sapiens)
as a component of
Processive complex:Okazaki fragment:Flap:RPA heterotrimer:dna2 [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer:DNA2 [nucleoplasm] (Homo sapiens)
DNA2:WRN [nucleoplasm] (Homo sapiens)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
Inferred To
dna-2 [nucleoplasm]
(Caenorhabditis elegans)
DNA2 [nucleoplasm]
(Bos taurus)
DNA2 [nucleoplasm]
(Canis familiaris)
DNA2 [nucleoplasm]
(Dictyostelium discoideum)
DNA2 [nucleoplasm]
(Gallus gallus)
DNA2 [nucleoplasm]
(Mus musculus)
DNA2 [nucleoplasm]
(Rattus norvegicus)
DNA2 [nucleoplasm]
(Saccharomyces cerevisiae)
DNA2 [nucleoplasm]
(Schizosaccharomyces pombe)
DNA2 [nucleoplasm]
(Sus scrofa)
Dna2 [nucleoplasm]
(Drosophila melanogaster)
Ghost homologue of DNA2 [nucleoplasm]
(Plasmodium falciparum)
Ghost homologue of DNA2 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001073918.2
OpenTargets
ENSG00000138346
HPA
ENSG00000138346-DNA2
GeneCards
P51530
Ensembl
ENST00000358410
,
ENSP00000351185
,
ENSP00000382132
,
ENST00000399179
,
ENSG00000138346
PRO
P51530
Pharos - Targets
P51530
Orphanet
22040
HMDB Protein
HMDBP11710
PDB
5EAY
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