Reactome | NABP1 [nucleoplasm]

NABP1 [nucleoplasm]

Stable Identifier

R-HSA-6814919

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

SOSS complex subunit B2, SOSB2_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA polymerase II transcribes snRNA genes (Homo sapiens)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        NABP1,2 [nucleoplasm] (Homo sapiens)
        
        NABP1 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        NABP1,2 [nucleoplasm] (Homo sapiens)
        
        NABP1 [nucleoplasm] (Homo sapiens)
    - Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene (Homo sapiens)
      - Integrator [nucleoplasm] (Homo sapiens)
        
        NABP1,2 [nucleoplasm] (Homo sapiens)
        
        NABP1 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        NABP1,2 [nucleoplasm] (Homo sapiens)
        
        NABP1 [nucleoplasm] (Homo sapiens)
    - Integrator complex processes the 3' end of snRNA (Homo sapiens)
      - Integrator [nucleoplasm] (Homo sapiens)
        
        NABP1,2 [nucleoplasm] (Homo sapiens)
        
        NABP1 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        NABP1,2 [nucleoplasm] (Homo sapiens)
        
        NABP1 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        NABP1,2 [nucleoplasm] (Homo sapiens)
        
        NABP1 [nucleoplasm] (Homo sapiens)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        NABP1,2 [nucleoplasm] (Homo sapiens)
        
        NABP1 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        NABP1,2 [nucleoplasm] (Homo sapiens)
        
        NABP1 [nucleoplasm] (Homo sapiens)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Homo sapiens)
      - Integrator [nucleoplasm] (Homo sapiens)
        
        NABP1,2 [nucleoplasm] (Homo sapiens)
        
        NABP1 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        NABP1,2 [nucleoplasm] (Homo sapiens)
        
        NABP1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96AH0 NABP1

Gene Names

NABP1, OBFC2A, SSB2

Chain

chain:1-204

Reference Genes

BioGPS Gene:64859 NABP1

COSMIC (genes):NABP1 NABP1

CTD Gene:64859 NABP1

dbSNP Gene:64859 NABP1

ENSEMBL:ENSG00000173559 NABP1

ENSEMBL_homo_sapiens_GENE:ENSG00000173559.15 NABP1

HGNC:26232 NABP1

KEGG Gene (Homo sapiens):64859 NABP1

Monarch:64859 NABP1

NCBI Gene:64859 NABP1

OMIM:612103 NABP1

UCSC:Q96AH0 NABP1

Reference Transcript

Other Identifiers

11726725_a_at

11726726_s_at

11726727_a_at

11726728_a_at

11763367_at

16888963

16888979

219334_PM_s_at

219334_s_at

222872_PM_x_at

222872_x_at

233085_PM_s_at

233085_s_at

2476138

2520565

2520566

2520567

2520568

2520569

2520570

2520572

2520574

2520578

2520579

2520581

2520584

2520585

2520586

2520587

2520598

2520599

2520600

2520601

2520602

2520603

2520604

2520605

2520606

2520607

2520608

2520610

2520627

2520629

2997298

3381703

3750867

3884593

42302_at

42721_at

48166_at

64859

77182_at

8047161

91414_at

A_14_P200716

A_14_P201747

A_19_P00330145

A_21_P0002334

A_23_P329198

A_33_P3298398

A_33_P3339701

GE600435

GE791277

GE79286

GE839419

GO:0000278

GO:0000724

GO:0000781

GO:0003677

GO:0003697

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005829

GO:0006281

GO:0006310

GO:0006974

GO:0010212

GO:0023052

GO:0035861

GO:0043226

GO:0044818

GO:0070876

HMNXSV003023333

HMNXSV003055550

Hs.118183.0.A1_3p_a_at

ILMN_1785852

ILMN_1898938

PH_hs_0005837

PH_hs_0006497

TC02001128.hg

TC02003747.hg

TC02003748.hg

TC02003749.hg

g12383083_3p_a_at

p21289

Participates

as a member of

NABP1,2 [nucleoplasm] (Homo sapiens)

Inferred To

NABP1 [nucleoplasm] (Bos taurus)

NABP1 [nucleoplasm] (Caenorhabditis elegans)

NABP1 [nucleoplasm] (Canis familiaris)

NABP1 [nucleoplasm] (Dictyostelium discoideum)

NABP1 [nucleoplasm] (Drosophila melanogaster)

NABP1 [nucleoplasm] (Gallus gallus)

NABP1 [nucleoplasm] (Sus scrofa)

nabp1 [nucleoplasm] (Danio rerio)

Nabp1 [nucleoplasm] (Mus musculus)

Nabp1 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_001026886.1, XP_016860211.1, NP_001241665.1

OpenTargets

ENSG00000173559

GeneCards

Q96AH0

HPA

ENSG00000173559-NABP1

Ensembl

ENST00000674406, ENSG00000173559, ENSP00000501415, ENSP00000386605, ENSP00000403683, ENSP00000387243, ENST00000409510, ENSP00000501340, ENST00000674262, ENST00000674360, ENSP00000501480, ENSP00000390901, ENSP00000501440, ENSP00000501496, ENST00000425611, ENST00000674187, ENST00000674172, ENST00000674414, ENST00000451500, ENSP00000307968, ENST00000307849, ENST00000410026, ENSP00000501487

PRO

Q96AH0

Pharos - Targets

Q96AH0

Orphanet

21981

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5VWX1 KHDRBS2	2	KHDRBS2 [nucleoplasm] (R-HSA-8849028) p-Y-KHDRBS2 [nucleoplasm] (R-HSA-8849031)	0.556	3

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