TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP

Stable Identifier
R-HSA-6814833
Type
Reaction
Species
Homo sapiens
Compartment
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TBC1D20 was identified as a RAB1-specific GTPase activating protein (GAP) that stimulates RAB1-mediated GTP hydrolysis and plays roles in ER-to-Golgi trafficking. TBC1D20 is the only GAP that has been identified to block delivery of secretory cargo from the ER to the cell surface (Haas et al, 2007).

Literature References
PubMed ID Title Journal Year
17684057 Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells

Haas, AK, Yoshimura, S, Stephens, DJ, Preisinger, C, Fuchs, E, Barr, FA

J. Cell. Sci. 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
GTPase activity of RAB1:GTP:TBC1D20 [endoplasmic reticulum-Golgi intermediate compartment membrane]
Physical Entity
Activity
Orthologous Events
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