Reactome | PDCL promotes formation of G-beta:G-gamma heterodimers

PDCL promotes formation of G-beta:G-gamma heterodimers

Stable Identifier

R-HSA-6814418

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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PDCL promotes formation of G-beta:G-gamma heterodimers

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G-protein gamma subunit binds folded G-protein beta subunits 1-4 associated with PDCL (PhLP1) after release from TRiC/CCT, resulting in formation of the G-protein beta:gamma complex (Lukov et al. 2006, Plimpton et al. 2015). In Pdcl-depleted mouse rods, G-protein beta:gamma dimer formation is decreased 50-fold, leading to 10-fold reduction in light sensitivity (Lai et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
23637185	Phosducin-like protein 1 is essential for G-protein assembly and signaling in retinal rod photoreceptors Frederick, JM, Lai, CW, Chen, CK, Baehr, W, Kolesnikov, AV, Blake, DR, Kefalov, VJ, Jiang, L, Barrow, JR, Stewart, JS, Willardson, BM	J. Neurosci.	2013
16717095	Mechanism of assembly of G protein betagamma subunits by protein kinase CK2-phosphorylated phosducin-like protein and the cytosolic chaperonin complex Thulin, CD, Lukov, GL, Ludtke, PJ, Hu, T, Carter, MD, Baker, CM, Hackett, RA, Willardson, BM	J. Biol. Chem.	2006
15889144	Phosducin-like protein acts as a molecular chaperone for G protein betagamma dimer assembly Lukov, GL, Hu, T, Hamm, HE, McLaughlin, JN, Willardson, BM	EMBO J.	2005
25675501	Structures of the Gβ-CCT and PhLP1-Gβ-CCT complexes reveal a mechanism for G-protein β-subunit folding and Gβγ dimer assembly Makaju, A, Lai, CW, Prince, JT, Carrascosa, JL, Plimpton, RL, Cuellar, J, Valpuesta, JM, Aoba, T, Franklin, S, Willardson, BM, Mathis, AD	Proc. Natl. Acad. Sci. U.S.A.	2015