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VPS52 [trans-Golgi network membrane]
Stable Identifier
R-HSA-6811029
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
trans-Golgi network membrane
Synonyms
Vacuolar protein sorting-associated protein 52 homolog, SAC2 suppressor of actin mutations 2-like protein
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
Retrograde transport at the Trans-Golgi-Network (Homo sapiens)
Fusion of early-endosome derived vesicles at the TGN (Homo sapiens)
GARP complex [trans-Golgi network membrane] (Homo sapiens)
VPS52 [trans-Golgi network membrane] (Homo sapiens)
RAB6:GTP:RIC1:RGP1:GARP complex:COG complex:AcM-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:Golgin dimers:STX6:STX16:VTI1A:VAMP4:early endosome-to-TGN cargo [trans-Golgi network membrane] (Homo sapiens)
GARP complex [trans-Golgi network membrane] (Homo sapiens)
VPS52 [trans-Golgi network membrane] (Homo sapiens)
Fusion of late-endosome derived vesicles at the TGN (Homo sapiens)
GARP complex [trans-Golgi network membrane] (Homo sapiens)
VPS52 [trans-Golgi network membrane] (Homo sapiens)
RAB9:GTP:p-RABEPK:VAMP3:STX16:STX10:VTI1A:GARP complex:GCC2 dimer:late-endosome-to-TGN cargo [trans-Golgi network membrane] (Homo sapiens)
GARP complex [trans-Golgi network membrane] (Homo sapiens)
VPS52 [trans-Golgi network membrane] (Homo sapiens)
RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles (Homo sapiens)
GARP complex [trans-Golgi network membrane] (Homo sapiens)
VPS52 [trans-Golgi network membrane] (Homo sapiens)
RAB6:GTP:RIC1:RGP1:GARP complex:COG complex:AcM-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:Golgin dimers:STX6:STX16:VTI1A:VAMP4:early endosome-to-TGN cargo [trans-Golgi network membrane] (Homo sapiens)
GARP complex [trans-Golgi network membrane] (Homo sapiens)
VPS52 [trans-Golgi network membrane] (Homo sapiens)
Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins (Homo sapiens)
GARP complex [trans-Golgi network membrane] (Homo sapiens)
VPS52 [trans-Golgi network membrane] (Homo sapiens)
RAB9:GTP:p-RABEPK:VAMP3:STX16:STX10:VTI1A:GARP complex:GCC2 dimer:late-endosome-to-TGN cargo [trans-Golgi network membrane] (Homo sapiens)
GARP complex [trans-Golgi network membrane] (Homo sapiens)
VPS52 [trans-Golgi network membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8N1B4 VPS52
Gene Names
VPS52, SACM2L
Chain
initiator methionine:, chain:2-723
Reference Genes
BioGPS Gene:6293 VPS52
COSMIC (genes):VPS52 VPS52
CTD Gene:6293 VPS52
dbSNP Gene:6293 VPS52
ENSEMBL:ENSG00000223501 VPS52
ENSEMBL_homo_sapiens_GENE:ENSG00000206286.11 VPS52
ENSEMBL_homo_sapiens_GENE:ENSG00000223501.9 VPS52
ENSEMBL_homo_sapiens_GENE:ENSG00000224455.9 VPS52
ENSEMBL_homo_sapiens_GENE:ENSG00000225590.9 VPS52
ENSEMBL_homo_sapiens_GENE:ENSG00000228425.9 VPS52
ENSEMBL_homo_sapiens_GENE:ENSG00000236014.10 VPS52
HGNC:10518 VPS52
KEGG Gene (Homo sapiens):6293 VPS52
Monarch:6293 VPS52
NCBI Gene:6293 VPS52
OMIM:603443 VPS52
UCSC:Q8N1B4 VPS52
Reference Transcript
RefSeq:NM_001289175.1 VPS52
RefSeq:XM_017011178.1 VPS52
RefSeq:NM_001289176.1 VPS52
RefSeq:NM_022553.5 VPS52
Other Identifiers
11717079_a_at
11717080_x_at
11717081_a_at
11746006_a_at
11746049_a_at
11746050_x_at
17018130
17029942
17032627
17034947
17037427
17040137
17042619
214585_PM_s_at
214585_s_at
2950516
2950517
2950518
2950519
2950520
2950521
2950523
2950524
2950527
2950529
2950530
2950533
2950535
2950536
2950539
2950541
2950542
2950543
2950544
2950545
2950546
2950548
2950549
2950550
2950551
2950555
2950556
2950557
32658_at
6293
8125649
8178917
8180123
A_23_P70583
GE55890
GO:0000938
GO:0005515
GO:0005768
GO:0005794
GO:0005829
GO:0006605
GO:0006886
GO:0006896
GO:0007041
GO:0010008
GO:0010668
GO:0015031
GO:0016020
GO:0016192
GO:0019905
GO:0030154
GO:0031410
GO:0032456
GO:0032588
GO:0042147
GO:0043226
GO:0048471
GO:0048611
GO:0048856
GO:0055037
GO:0090119
GO:1990745
HMNXSV003045901
HMNXSV003058089
Hs.169407.1.A2_3p_a_at
ILMN_1666632
PH_hs_0020146
TC06001581.hg
TC6_cox_hap2000205.hg
TC6_dbb_hap3000191.hg
TC6_mann_hap4000173.hg
TC6_mcf_hap5000180.hg
TC6_qbl_hap6000193.hg
TC6_ssto_hap7000174.hg
Participates
as a component of
GARP complex [trans-Golgi network membrane] (Homo sapiens)
Inferred To
vps52 [trans-Golgi network membrane]
(Schizosaccharomyces pombe)
VPS52 [trans-Golgi network membrane]
(Bos taurus)
VPS52 [trans-Golgi network membrane]
(Canis familiaris)
VPS52 [trans-Golgi network membrane]
(Saccharomyces cerevisiae)
VPS52 [trans-Golgi network membrane]
(Sus scrofa)
Vps52 [trans-Golgi network membrane]
(Drosophila melanogaster)
Vps52 [trans-Golgi network membrane]
(Mus musculus)
Vps52 [trans-Golgi network membrane]
(Rattus norvegicus)
Ghost homologue of VPS52 [trans-Golgi network membrane]
(Danio rerio)
Ghost homologue of VPS52 [trans-Golgi network membrane]
(Gallus gallus)
vps-52 [trans-Golgi network membrane]
(Caenorhabditis elegans)
vps52B [trans-Golgi network membrane]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_001276105.1
,
NP_001276104.1
,
NP_072047.4
,
XP_016866667.1
OpenTargets
ENSG00000223501
GeneCards
Q8N1B4
HPA
ENSG00000223501-VPS52
Ensembl
ENSG00000228425
,
ENST00000383210
,
ENSG00000224455
,
ENSP00000409952
,
ENSG00000236014
,
ENSG00000223501
,
ENSP00000391197
,
ENSP00000404016
,
ENST00000428608
,
ENSP00000390831
,
ENSP00000406988
,
ENST00000441058
,
ENST00000445902
,
ENSG00000206286
,
ENST00000443860
,
ENSP00000372697
,
ENST00000448042
,
ENSG00000225590
PRO
Q8N1B4
Pharos - Targets
Q8N1B4
Interactors (18)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O75604 USP2
2
USP2 [cytosol]
(R-HSA-5212661)
USP2 [nucleoplasm]
(R-HSA-5689946)
0.718
6
UniProt:Q99757 TXN2
2
TXN2 [mitochondrial matrix]
(R-HSA-3323048)
2xHC-TXN2 [mitochondrial matrix]
(R-HSA-3323059)
0.718
6
UniProt:P40222 TXLNA
1
TXLNA [cytosol]
(R-HSA-449124)
0.718
6
UniProt:Q9Y4K3 TRAF6
8
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
TRAF6 [endosome membrane]
(R-HSA-450272)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
0.718
6
UniProt:Q9H4P4 RNF41
1
RNF41 [cytosol]
(R-HSA-975977)
0.718
6
UniProt:P55081 MFAP1
1
MFAP1 [nucleoplasm]
(R-HSA-2396419)
0.718
6
UniProt:P55040 GEM
1
GEM [plasma membrane]
(R-HSA-9769962)
0.556
3
UniProt:P54646 PRKAA2
4
PRKAA2 [cytosol]
(R-HSA-200405)
p-T172-PRKAA2 [cytosol]
(R-HSA-200417)
p-T172-PRKAA2 [nucleoplasm]
(R-HSA-164171)
PRKAA2 [nucleoplasm]
(R-HSA-163682)
0.556
3
UniProt:Q96NC0 ZMAT2
1
ZMAT2 [nucleoplasm]
(R-HSA-9770248)
0.556
3
UniProt:Q13895 BYSL
2
BYSL [nucleoplasm]
(R-HSA-6791526)
BYSL [cytosol]
(R-HSA-6791518)
0.556
3
UniProt:Q15561 TEAD4
1
TEAD4 [nucleoplasm]
(R-HSA-2032780)
0.556
3
UniProt:P46087 NOP2
1
NOP2 [nucleoplasm]
(R-HSA-6790922)
0.556
3
UniProt:Q9HAQ2 KIF9
1
KIF9 [cytosol]
(R-HSA-984616)
0.556
3
UniProt:Q86TI0 TBC1D1
2
TBC1D1 [cytoplasmic vesicle membrane]
(R-HSA-1454718)
p-S237-TBC1D1 [cytosol]
(R-HSA-1454673)
0.556
3
UniProt:Q92917 GPKOW
1
GPKOW [nucleoplasm]
(R-HSA-8850839)
0.556
3
UniProt:Q2TBE0 CWF19L2
1
CWF19L2 [nucleoplasm]
(R-HSA-9770846)
0.556
3
UniProt:Q9NVH1 DNAJC11
1
DNAJC11 [mitochondrial outer membrane]
(R-HSA-8949572)
0.556
3
UniProt:O14964 HGS
2
HGS [cytosol]
(R-HSA-182954)
HGS [phagocytic vesicle lumen]
(R-HSA-9635660)
0.556
3
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