Reactome | PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus

PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus

Stable Identifier

R-HSA-6810410

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Acetylation (Homo sapiens)
        
        PI5P Regulates TP53 Acetylation (Homo sapiens)
        
        PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Homo sapiens)

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PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus

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Translocation of TMEM55B (type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase) to the nucleus under conditions of cellular stress leads to dephosphorylation of nuclear PI(4,5)P2 to PI5P, thus increasing the concentration of PI5P in the nucleus (Zou et al. 2007). PIP2 and its derivatives are not associated with nuclear envelope structures (Bornenkov et al. 1998) but localize to poorly defined subnuclear compartments called nuclear specks (reviewed by Barlow et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
17940011	Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis Marjanovic, J, Majerus, PW, Kisseleva, MV, Wilson, M, Zou, J	Proc. Natl. Acad. Sci. U.S.A.	2007