Reactome | ING2 binds PI5P

ING2 binds PI5P

Stable Identifier

R-HSA-6810376

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm, nuclear envelope

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Acetylation (Homo sapiens)
        
        PI5P Regulates TP53 Acetylation (Homo sapiens)
        
        ING2 binds PI5P (Homo sapiens)

General

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The PHD finger of ING2 binds phosphatidylinositol-5-phosphate (PI5P) (Gozani et al. 2003), which promotes nuclear retention of ING2 (Jones et al. 2006, Zou et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17940011	Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis Marjanovic, J, Majerus, PW, Kisseleva, MV, Wilson, M, Zou, J	Proc. Natl. Acad. Sci. U.S.A.	2007
16949365	Nuclear PtdIns5P as a transducer of stress signaling: an in vivo role for PIP4Kbeta Jones, DR, D'Santos, CS, Bultsma, Y, Heck, AJ, Keune, WJ, Halstead, JR, Divecha, N, Mohammed, S, Elouarrat, D	Mol. Cell	2006
12859901	The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor Ivanov, D, Jones, DR, Zhu, H, Baird, CL, Lessnick, SL, Gozani, O, Mehrotra, B, Prestwich, GD, Wagner, G, Myszka, DG, Ferguson, CG, Field, SJ, Cantley, LC, Lugovskoy, AA, Cha, J, Karuman, P, Payrastre, B, Brugge, JS, Yuan, J, Villasenor, J, Divecha, N, Rao, VR, Chen, J	Cell	2003