Monoubiquitinated PTEN translocates to the nucleus

Stable Identifier
R-HSA-6807105
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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Monoubiquitinated PTEN translocates to the nucleus
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Monoubiquitinated PTEN translocates to the nucleus. Lysine residues K13 and K289 of PTEN are important monoubiquitination targets and their mutation abrogates PTEN nuclear localization (Trotman et al. 2007).
Literature References
PubMed ID Title Journal Year
17218261 Ubiquitination regulates PTEN nuclear import and tumor suppression

Trotman, LC, Wang, X, Carver, BS, Jiang, X, Pavletich, NP, Tempst, P, Erdjument-Bromage, H, Teruya-Feldstein, J, Pandolfi, PP, Misteli, T, Cordon-Cardo, C, Chen, Z, Kim, HJ, Chi, SG, Yang, H, Alimonti, A

Cell 2007
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Monoubiquitinated PTEN translocates to the nucleus (Saccharomyces cerevisiae)
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Authored
Orlic-Milacic, M  (2015-10-29)
Reviewed
Salmena, L  (2016-08-11)
Leslie, N  (2016-09-30)
Kriplani, N  (2016-09-30)
Carracedo, A  (2016-08-11)
Created
Orlic-Milacic, M  (2015-10-29)
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