Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
Cholesterol biosynthesis via desmosterol
Stable Identifier
R-HSA-6807047
Type
Pathway
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
,
cytosol
Synonyms
Bloch pathway
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Cholesterol biosynthesis (Homo sapiens)
Cholesterol biosynthesis via desmosterol (Homo sapiens)
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
|
PPTX
|
SBGN
Click the image above or
here
to open this pathway in the Pathway Browser
The transformation of zymosterol into cholesterol can follow either of routes, one in which reduction of the double bond in the isooctyl side chain is the final step (cholesterol synthesis via desmosterol, also known as the Bloch pathway) and one in which this reduction is the first step (cholesterol biosynthesis via lathosterol, also known as the Kandutsch-Russell pathway). The former pathway is prominent in the liver and many other tissues while the latter is prominent in skin, where it may serve as the source of the 7-dehydrocholesterol that is the starting point for the synthesis of D vitamins (Mitsche et al. 2015).
Literature References
PubMed ID
Title
Journal
Year
26114596
Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways
Hobbs, HH
,
Mitsche, MA
,
Cohen, JC
,
McDonald, JG
Elife
2015
Participants
Events
Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol
(Homo sapiens)
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol
(Homo sapiens)
Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol
(Homo sapiens)
Reduction of desmosterol to cholesterol
(Homo sapiens)
Participates
as an event of
Cholesterol biosynthesis (Homo sapiens)
Event Information
Go Biological Process
cholesterol biosynthetic process via desmosterol (0033489)
Orthologous Events
Cholesterol biosynthesis via desmosterol (Bos taurus)
Cholesterol biosynthesis via desmosterol (Caenorhabditis elegans)
Cholesterol biosynthesis via desmosterol (Canis familiaris)
Cholesterol biosynthesis via desmosterol (Danio rerio)
Cholesterol biosynthesis via desmosterol (Dictyostelium discoideum)
Cholesterol biosynthesis via desmosterol (Gallus gallus)
Cholesterol biosynthesis via desmosterol (Mus musculus)
Cholesterol biosynthesis via desmosterol (Rattus norvegicus)
Cholesterol biosynthesis via desmosterol (Saccharomyces cerevisiae)
Cholesterol biosynthesis via desmosterol (Schizosaccharomyces pombe)
Cholesterol biosynthesis via desmosterol (Sus scrofa)
Cholesterol biosynthesis via desmosterol (Xenopus tropicalis)
Authored
D'Eustachio, P (2015-11-02)
Reviewed
Jassal, B (2015-11-02)
Created
D'Eustachio, P (2015-10-29)
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text