Reactome | HSPA6 [extracellular region]

HSPA6 [extracellular region]

Stable Identifier

R-HSA-6806500

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Heat shock 70 kDa protein 6

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P17066 HSPA6

Gene Names

HSPA6, HSP70B'

Chain

chain:1-643

Reference Genes

BioGPS Gene:3310 HSPA6

COSMIC (genes):HSPA6 HSPA6

CTD Gene:3310 HSPA6

dbSNP Gene:3310 HSPA6

ENSEMBL:ENSG00000173110 HSPA6

ENSEMBL_homo_sapiens_GENE:ENSG00000173110.8 HSPA6

HGNC:5239 HSPA6

KEGG Gene (Homo sapiens):3310 HSPA6

Monarch:3310 HSPA6

NCBI Gene:3310 HSPA6

OMIM:140555 HSPA6

UCSC:P17066 HSPA6

Reference Transcript

RefSeq:NM_002155.4 HSPA6

Other Identifiers

11723050_a_at

11757367_s_at

117_3p_at

117_PM_at

117_at

16672914

213418_PM_at

213418_at

2363785

2363786

2363787

2363788

2363789

2363790

2363791

2363792

2363793

2363794

2363795

2363796

2363797

3310

35965_at

56711_s_at

7906764

7906775

A_14_P107820

A_23_P114903

GE59761

GO:0000166

GO:0003824

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005814

GO:0005815

GO:0005829

GO:0005856

GO:0006457

GO:0006986

GO:0008180

GO:0016787

GO:0016887

GO:0019899

GO:0031072

GO:0031410

GO:0031625

GO:0034605

GO:0034774

GO:0042026

GO:0043226

GO:0044183

GO:0051082

GO:0051085

GO:0070062

GO:0072562

GO:0140657

GO:0140662

GO:1904813

Hs.3268.0.S1_3p_at

ILMN_1658383

ILMN_1806165

PH_hs_0000400

TC01001401.hg

TC01004796.hg

X51757_at

X51757cds_3p_at

X51757cds_3p_s_at

Participates

as a member of

Other forms of this molecule

HSPA6 [cytosol]

HSPA6 [nucleoplasm]

HSPA6 [secretory granule lumen]

HSPA6 [ficolin-1-rich granule lumen]

Inferred To

Homologues of HSPA6 [extracellular region] (Danio rerio)

Homologues of HSPA6 [extracellular region] (Dictyostelium discoideum)

Homologues of HSPA6 [extracellular region] (Plasmodium falciparum)

Homologues of HSPA6 [extracellular region] (Saccharomyces cerevisiae)

Homologues of HSPA6 [extracellular region] (Schizosaccharomyces pombe)

SSA2 [extracellular region] (Saccharomyces cerevisiae)

SSA1 [extracellular region] (Saccharomyces cerevisiae)

zgc:174006 [extracellular region] (Danio rerio)

SSA3 [extracellular region] (Saccharomyces cerevisiae)

SSA4 [extracellular region] (Saccharomyces cerevisiae)

ssa1 [extracellular region] (Schizosaccharomyces pombe)

HSPA6 [extracellular region] (Bos taurus)

HSPA6 [extracellular region] (Caenorhabditis elegans)

HSPA6 [extracellular region] (Dictyostelium discoideum)

HSPA6 [extracellular region] (Plasmodium falciparum)

HSPA6 [extracellular region] (Saccharomyces cerevisiae)

HSPA6 [extracellular region] (Schizosaccharomyces pombe)

HSPA6 [extracellular region] (Sus scrofa)

hspB [extracellular region] (Dictyostelium discoideum)

hsp70 [extracellular region] (Danio rerio)

LOC560210 [extracellular region] (Danio rerio)

ssa2 [extracellular region] (Schizosaccharomyces pombe)

hspE-2 [extracellular region] (Dictyostelium discoideum)

Cross References

RefSeq

NP_002146.2

Guide to Pharmacology - Targets

2542

OpenTargets

ENSG00000173110

GeneCards

P17066

HPA

ENSG00000173110-HSPA6

Ensembl

ENST00000309758, ENSP00000310219, ENSG00000173110

PRO

P17066

Pharos - Targets

P17066

PDB

3FE1

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q99558 MAP3K14	5	p-T559-MAP3K14 [cytosol] (R-HSA-5668531) K48polyUb-NIK [cytosol] (R-HSA-5668525) Active NIK [cytosol] (R-HSA-5607646) MAP3K14 [cytosol] (R-HSA-168189) p-MAP3K14 [cytosol] (R-HSA-168187)	0.564	3
UniProt:O95429 BAG4	3	BAG4 [cytosol] (R-HSA-5212670) BAG4(1-126)-p-8Y-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853156) BAG4(1-126)-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853157)	0.556	3
UniProt:P27694 RPA1	2	polySUMO2,3-K449,K577-RPA1 [nucleoplasm] (R-HSA-4551644) RPA1 [nucleoplasm] (R-HSA-68461)	0.556	3
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.527	3

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