Reactome | IMPDH2 [extracellular region]

IMPDH2 [extracellular region]

Stable Identifier

R-HSA-6806455

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

IMP (inosine monophosphate) dehydrogenase 2, Inosine-5'-monophosphate dehydrogenase 2 (EC 1.1.1.205) (IMP dehydrogenase 2) (IMPDH-II) (IMPD 2), Inosine-5'-monophosphate dehydrogenase 2 , IMP dehydrogenase 2, IMPDH-II, IMPD 2

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P12268 IMPDH2

Gene Names

IMPDH2, IMPD2

Chain

initiator methionine:, chain:2-514

Reference Genes

BioGPS Gene:3615 IMPDH2

COSMIC (genes):IMPDH2 IMPDH2

CTD Gene:3615 IMPDH2

dbSNP Gene:3615 IMPDH2

ENSEMBL:ENSG00000178035 IMPDH2

ENSEMBL_homo_sapiens_GENE:ENSG00000178035.13 IMPDH2

HGNC:6053 IMPDH2

KEGG Gene (Homo sapiens):3615 IMPDH2

Monarch:3615 IMPDH2

NCBI Gene:3615 IMPDH2

OMIM:146691 IMPDH2

UCSC:P12268 IMPDH2

Reference Transcript

RefSeq:NM_000884.2 IMPDH2

Other Identifiers

11740923_a_at

11740924_x_at

11744423_a_at

11752370_x_at

11757427_x_at

16953813

201892_PM_s_at

201892_s_at

2673875

2673877

2673879

2673881

2673882

2673885

2673886

2673887

2673889

2673890

2673893

2673895

2673898

2673900

2673901

3615

36624_at

8087254

A_33_P3214298

GE57726

GO:0000166

GO:0002376

GO:0003677

GO:0003723

GO:0003824

GO:0003938

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005777

GO:0005778

GO:0005829

GO:0006164

GO:0006177

GO:0006183

GO:0007623

GO:0016020

GO:0016491

GO:0031410

GO:0034774

GO:0043226

GO:0046651

GO:0046872

GO:0055086

GO:0070062

GO:0071353

GO:0097294

GO:1901135

GO:1904813

HMNXSV003008658

L33842_rna1_at

PH_hs_0004326

PH_hs_0035456

TC03001397.hg

g4504688_3p_s_at

Participates

as a member of

Other forms of this molecule

IMPDH2 [secretory granule lumen]

IMPDH2 [ficolin-1-rich granule lumen]

IMPDH2 [cytosol]

Inferred To

IMPDH2 [extracellular region] (Bos taurus)

IMPDH2 [extracellular region] (Canis familiaris)

IMPDH2 [extracellular region] (Danio rerio)

IMPDH2 [extracellular region] (Gallus gallus)

IMPDH2 [extracellular region] (Mus musculus)

IMPDH2 [extracellular region] (Rattus norvegicus)

IMPDH2 [extracellular region] (Sus scrofa)

IMPDH1 [extracellular region] (Caenorhabditis elegans)

IMPDH1 [extracellular region] (Dictyostelium discoideum)

IMPDH1 [extracellular region] (Drosophila melanogaster)

IMPDH1 [extracellular region] (Plasmodium falciparum)

IMPDH1 [extracellular region] (Saccharomyces cerevisiae)

IMPDH1 [extracellular region] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_000875.2

ZINC - World Drugs

IMDH2_HUMAN

Guide to Pharmacology - Targets

2625

OpenTargets

ENSG00000178035

ZINC - FDA approved

IMDH2_HUMAN

ZINC - Substances

IMDH2_HUMAN

ZINC - Biogenic

IMDH2_HUMAN

ZINC target

P12268

PRO

P12268

PDB

8G9B, 1NF7, 6U8S, 6UA5, 6UDQ, 6U8N, 6UC2, 8G8F, 1NFB, 6U8R, 6UDP, 6I0M, 6UDO, 6UAJ, 6I0O, 6U9O, 8FOZ, 6UA4, 6U8E, 8FUZ, 1B3O, 6UA2

IntEnz

1.1.1.205

GeneCards

P12268

HPA

ENSG00000178035-IMPDH2

Ensembl

ENSP00000321584, ENSG00000178035, ENST00000326739

Pharos - Targets

P12268

ZINC - Predictions - Purchasable

IMDH2_HUMAN

HMDB Protein

HMDBP00881

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96GX9 APIP	1	APIP [cytosol] (R-HSA-1237171)	0.556	3
UniProt:Q8WWZ1 IL1F10	3	IL1F10(?-152) [extracellular region] (R-HSA-9007903) IL1F10(1-?) [extracellular region] (R-HSA-9007899) IL1F10 [extracellular region] (R-HSA-8863045)	0.556	3
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.556	3
UniProt:P40763 STAT3	12	Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [nucleoplasm] (R-HSA-8983188) p-STAT3 [cytosol] (R-HSA-8982823) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [cytosol] (R-HSA-8983130) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-914048) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554)	0.556	3
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.527	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	11
UniProt:P0DTC4 E	9	N-glycan E [endoplasmic reticulum lumen] (R-COV-9694754) nascent E [endoplasmic reticulum lumen] (R-COV-9694312) 3xPalmC-E [endoplasmic reticulum lumen] (R-COV-9694305) Ub-3xPalmC-E [endoplasmic reticulum lumen] (R-COV-9694423) Ub-3xPalmC-E [endoplasmic reticulum membrane] (R-COV-9694465) Ub-3xPalmC-E [Golgi membrane] (R-COV-9694687) Ub-3xPalmC-E [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698420) Ub-3xPalmC-E [endocytic vesicle membrane] (R-COV-9698422) Ub-3xPalmC-E [virion membrane] (R-COV-9698416)	0.482	2

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