AKT phosphorylates PHF20

Stable Identifier
R-HSA-6805785
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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AKT phosphorylates PHF20 on serine residue S291 (Li et al. 2013). AKT-mediated PHF20 phosphorylation inhibits DNA damage-induced stabilitzation of TP53 protein (Li et al. 2013).
Literature References
PubMed ID Title Journal Year
22975685 PKB-mediated PHF20 phosphorylation on Ser291 is required for p53 function in DNA damage

Piao, L, Kim, Y, Kim, SH, Park, J, Brazil, DP, Hong, J, Park, J, Yoo, BC, Kong, G, Seok, JH, Choi, SW, Hur, GM, Park, KA, Zhang, T, Li, Y, Hemmings, BA

Cell. Signal. 2013
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of p-T,p-S-AKT [nucleoplasm]

Orthologous Events
Authored
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Created
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