Reactome | CARD8 [cytosol]

CARD8 [cytosol]

Stable Identifier

R-HSA-6805447

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Caspase recruitment domain-containing protein 8, TUCAN, Tumor up-regulated CARD-containing antagonist of CASP9, CARD-inhibitor of NF-kappa-B-activating ligand, Apoptotic protein NDPP1, CARDINAL

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9Y2G2 CARD8

Gene Names

CARD8, DACAR, KIAA0955, NDPP1

Chain

chain:1-537, chain:1-296, chain:297-537

Reference Genes

BioGPS Gene:22900 CARD8

COSMIC (genes):CARD8 CARD8

CTD Gene:22900 CARD8

dbSNP Gene:22900 CARD8

ENSEMBL:ENSG00000105483 CARD8

ENSEMBL_homo_sapiens_GENE:ENSG00000105483.18 CARD8

HGNC:17057 CARD8

KEGG Gene (Homo sapiens):22900 CARD8

Monarch:22900 CARD8

NCBI Gene:22900 CARD8

OMIM:609051 CARD8

UCSC:Q9Y2G2 CARD8

Reference Transcript

Other Identifiers

11740035_a_at

11740036_at

11746055_a_at

11746906_s_at

11747437_a_at

11747703_x_at

11755070_a_at

11760244_a_at

11763365_x_at

1554479_PM_a_at

1554479_a_at

16873880

204950_PM_at

204950_at

228641_3p_at

228641_PM_at

228641_at

22900

3866976

3866977

3866978

3866979

3866980

3866983

3866988

3866990

3866992

3866993

3866994

3866995

3866997

3867003

3867004

3867005

3867006

3867007

3867011

3867012

3867016

3867017

3867018

3867019

3867020

3867021

41100_at

43059_at

43060_g_at

8038029

91036_at

A_21_P0000098

A_23_P27721

A_24_P14260

A_24_P196688

GE53621

GO:0002376

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006508

GO:0006915

GO:0006954

GO:0008233

GO:0008656

GO:0010804

GO:0012501

GO:0016787

GO:0023052

GO:0031665

GO:0032088

GO:0032089

GO:0032691

GO:0032731

GO:0032991

GO:0038187

GO:0042803

GO:0042981

GO:0043122

GO:0043124

GO:0043226

GO:0043280

GO:0045087

GO:0050700

GO:0051604

GO:0051607

GO:0060089

GO:0060090

GO:0061702

GO:0065003

GO:0072559

GO:0097264

GO:0097340

GO:0098542

GO:0098772

GO:0140096

GO:0140374

GO:0140608

GO:0140633

GO:0140693

GO:1900226

HMNXSV003002858

HMNXSV003023078

Hs.10031.1.S1_3p_at

Hs.10031.1.S1_3p_s_at

Hs2.10031.2.S1_3p_s_at

ILMN_2192281

PH_hs_0026073

TC19001677.hg

TC19002534.hg

g7662403_3p_at

Participates

as a component of

CASP9:CARD [cytosol] (Homo sapiens)

as an input of

CARD8 binds CASP9(1-416) (Homo sapiens)

This entity regulates

Negatively

CYCS:APAF1 binds procaspase-9 (Homo sapiens)

Inferred To

LOC119876002 [cytosol] (Canis familiaris)

CARD8 [cytosol] (Gallus gallus)

pycard [cytosol] (Danio rerio)

Cross References

RefSeq

XP_006723158.1, XP_006723160.1, XP_011524945.1, XP_006723159.1, NP_001171830.1, NP_055774.2, XP_011524944.1, NP_001171831.1, XP_006723173.1, NP_001171829.1, XP_006723172.1, XP_016881972.1, XP_006723154.1, NP_001171833.1, XP_011524943.1, NP_001171832.1, XP_006723169.1, XP_016881987.1, XP_006723156.1, XP_011524946.1, XP_016881979.1, XP_006723155.1, XP_006723167.1, XP_011524952.1

OpenTargets

ENSG00000105483

HPA

ENSG00000105483-CARD8

GeneCards

Q9Y2G2

Ensembl

ENST00000651546, ENST00000520753, ENST00000520007, ENST00000519940, ENSP00000427858, ENST00000520153, ENSP00000427727, ENSP00000499211, ENST00000391898, ENST00000447740, ENST00000521613, ENST00000519332, ENSP00000375767, ENSP00000428883, ENSP00000429839, ENSP00000427922, ENSP00000428736, ENSP00000430108, ENST00000520015, ENST00000522431, ENSP00000391248, ENSG00000105483, ENSP00000430747

PRO

Q9Y2G2

Pharos - Targets

Q9Y2G2

Orphanet

28718

PDB

7JKQ, 6K9F, 6XKJ, 7JN7, 4IKM

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14192 FHL2	1	FHL2 [nucleoplasm] (R-HSA-561161)	0.508	2
UniProt:Q9Y2G2 CARD8	1	CARD8 [cytosol] (R-HSA-6805447)	0.508	2