Reactome | p-5S,T-MDM2 [nucleoplasm]

p-5S,T-MDM2 [nucleoplasm]

Stable Identifier

R-HSA-6804954

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

p-S166,S188,S386,S395,S407,T419-MDM2

Icon

Locations in the PathwayBrowser for interactor UniProt:P61978 HNRNPK

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Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - G1/S DNA Damage Checkpoints (Homo sapiens)
    - p53-Dependent G1/S DNA damage checkpoint (Homo sapiens)
      - p53-Dependent G1 DNA Damage Response (Homo sapiens)
        
        Stabilization of p53 (Homo sapiens)
        
        ATM phosphorylates MDM2 (Homo sapiens)
        
        p-5S,T-MDM2 [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Expression and Degradation (Homo sapiens)
        
        Regulation of TP53 Degradation (Homo sapiens)
        
        ATM phosphorylates MDM2 (Homo sapiens)
        
        p-5S,T-MDM2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q00987 MDM2

Gene Names

MDM2

Chain

chain:1-491

Reference Genes

BioGPS Gene:4193 MDM2

COSMIC (genes):MDM2 MDM2

CTD Gene:4193 MDM2

dbSNP Gene:4193 MDM2

ENSEMBL:ENSG00000135679 MDM2

HGNC:6973 MDM2

KEGG Gene (Homo sapiens):4193 MDM2

Monarch:4193 MDM2

NCBI Gene:4193 MDM2

OMIM:164785 MDM2

UCSC:Q00987 MDM2

Reference Transcript

Other Identifiers

0000070278

0002320113

0002690017

11731564_x_at

11731565_x_at

11731566_a_at

11731567_a_at

11731568_x_at

11753563_x_at

11753688_a_at

11753689_x_at

11753819_a_at

11753820_x_at

11756046_x_at

16303

16753853

1859_s_at

1880_at

1RV1

1T4E

1T4F

1YCR

1Z1M

2008_s_at

205386_s_at

211832_s_at

217373_x_at

217542_at

217557_3p_s_at

217557_s_at

225160_x_at

229711_s_at

238733_at

244616_3p_x_at

244616_x_at

2AXI

2C6A

2C6B

2F1Y

2FOP

2GV2

2HDP

2LZG

2M86

2MPS

2RUH

2VJE

2VJF

3421301

3421302

3421303

3421304

3421305

3421306

3421307

3421310

3421311

3421315

3421316

3421322

3421323

3421325

3421328

3421329

3421334

3421335

3421336

3421337

3421338

3421339

3421340

3421341

3421342

3421343

3421344

3421345

3421346

3421347

3421348

3421349

3421350

3421351

3421361

3421363

3421365

3421366

3421368

3421369

3421371

38509_at

3979479

3EQS

3G03

3IUX

3IWY

3JZK

3JZR

3JZS

3LBK

3LBL

3LNJ

3LNZ

3MQS

3TJ2

3TPX

3TU1

3V3B

3VBG

3VZV

3W69

4193

46744_s_at

4DIJ

4ERE

4ERF

4HBM

4HFZ

4HG7

4JV7

4JV9

4JVE

4JVR

4JWR

4MDN

4MDQ

4OAS

4OBA

4OCC

4ODE

4ODF

4OGN

4OGT

4OGV

4OQ3

4QO4

4QOC

4UD7

4UE1

4UMN

4WT2

4XXB

4ZFI

4ZGK

4ZYC

4ZYF

4ZYI

53464_at

5AFG

5C5A

5HMH

5HMI

5HMK

5J7F

5J7G

5LAV

5LAW

5LAY

5LAZ

5LN2

5MNJ

5OC8

5SWK

5TRF

5UMM

5VK0

5WTS

5XXK

5Z02

5ZXF

61888_at

62280_at

64992_i_at

64993_r_at

6GGN

6I3S

75871_at

7956989

A0A0A8K981

A0A0A8K986

A0A0A8K9A9

A0A0A8K9F1

A0A0A8KB88

A0A0A8KBA1

A0A1B0GXJ6

A7UKX8

A7UKY0

A_14_P112137

A_14_P118388

A_14_P133404

A_14_P135914

A_23_P139895

A_23_P309545

A_23_P502750

A_24_P925664

A_33_P3361707

AAA60568

AAA75514

AAA75515

AAA75516

AAA75517

AAA75518

AAA82061

AAA82237

AAF42995

AAL40179

AAL40180

AAM78554

AAP35922

AC025423

AF092844

AF092845

AF201370

AF527840

AJ251943

AK290341

BAF83030

BC009893

BT007258

CAA78055

CAB000086

CAB016303

CAB64448

CCDS61189

CCDS8986

E7EMW5

ENSG00000135679

ENSP00000258149

ENSP00000299252

ENSP00000353611

ENSP00000377065

ENSP00000444430

ENST00000258149

ENST00000258149.9

ENST00000299252

ENST00000299252.8

ENST00000360430

ENST00000360430.6

ENST00000393413

ENST00000393413.7

ENST00000539479

ENST00000539479.6

EntrezGene:4193

EntrezGene:MDM2

F5GZC3

F5H1M7

F5H4Q8

G3XA89

g7230489_3p_s_at

GE58146

GE832699

GE83502

GO:0000122

GO:0000278

GO:0001568

GO:0001974

GO:0002027

GO:0002039

GO:0003013

GO:0003170

GO:0003181

GO:0003203

GO:0003281

GO:0003283

GO:0003674

GO:0003723

GO:0004842

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005829

GO:0005886

GO:0006464

GO:0006511

GO:0006810

GO:0006913

GO:0006950

GO:0006977

GO:0007049

GO:0007089

GO:0007165

GO:0007507

GO:0008097

GO:0008150

GO:0008219

GO:0008270

GO:0008283

GO:0008284

GO:0009056

GO:0009058

GO:0009636

GO:0010039

GO:0010468

GO:0010628

GO:0010629

GO:0010955

GO:0010977

GO:0016032

GO:0016567

GO:0016579

GO:0016604

GO:0016740

GO:0016874

GO:0016925

GO:0018205

GO:0019789

GO:0019843

GO:0019899

GO:0019904

GO:0022607

GO:0030154

GO:0030666

GO:0031410

GO:0031625

GO:0031648

GO:0032026

GO:0032182

GO:0032436

GO:0032991

GO:0033612

GO:0034504

GO:0034641

GO:0036369

GO:0040011

GO:0042176

GO:0042220

GO:0042493

GO:0042802

GO:0042975

GO:0043021

GO:0043066

GO:0043130

GO:0043154

GO:0043167

GO:0043226

GO:0043278

GO:0043518

GO:0044403

GO:0045184

GO:0045202

GO:0045472

GO:0045787

GO:0045892

GO:0045931

GO:0046677

GO:0046827

GO:0046872

GO:0047485

GO:0048545

GO:0048856

GO:0048870

GO:0051603

GO:0051604

GO:0051865

GO:0060411

GO:0061630

GO:0061663

GO:0065003

GO:0070301

GO:0071157

GO:0071236

GO:0071301

GO:0071310

GO:0071312

GO:0071363

GO:0071375

GO:0071391

GO:0071407

GO:0071456

GO:0071480

GO:0071494

GO:0072717

GO:0097110

GO:0097718

GO:1901796

GO:1901797

GO:1902254

GO:1904404

GO:1904707

GO:1904754

GO:1990000

GO:1990785

HGNC:6973

Hs.116932.0.A1_3p_at

Hs.168732.0.A1_3p_at

Hs.168732.0.A1_3p_x_at

Hs.267158.1.S1_3p_at

Hs.272346.0.S1_3p_s_at

Hs.332938.1.S1_3p_a_at

Hs.37494.0.A1_3p_at

ILMN_1736829

ILMN_1814208

ILMN_2389851

IPR001841

IPR001876

IPR003121

IPR013083

IPR015459

IPR016495

IPR028340

IPR036443

IPR036885

J3KN53

J3QST1

M92424

M92424_at

MDM2

MDM2-202

MDM2-203

MDM2-207

MDM2-210

MDM2-225

MIM:164785

MIM:614401

NM_001145337

NM_001145340

NM_001278462

NM_001367990

NM_002392

NP_001138809

NP_001138812

NP_001265391

NP_001354919

NP_002383

PF00641

PF02201

PF13920

PH_hs_0023082

Q8TE47

Q96DS5

Q9H4C3

Q9H4C5

TC12000606.hg

TC12002437.hg

U28935

U33199

U33200

U33201

U33202

U33202_s_at

U33203

U33203_s_at

U39736

UPI000002ADC4

UPI000002ADC6

UPI000002ADC7

UPI000002E23E

UPI00006CA35C

Z12020

Participant Of

output

ATM phosphorylates MDM2

Other forms of this molecule

PolyUb-MDM2 [nucleoplasm]

SUMO1-K182-MDM2 [nucleoplasm]

MDM2 [plasma membrane]

MDM2 [endocytic vesicle membrane]

p-S166,S188,T218-MDM2 [nucleoplasm]

PolyUb,p-S166,S188-MDM2 [nucleoplasm]

MDM2 [nucleoplasm]

MDM2 [cytosol]

p-S166,S188-MDM2 [cytosol]

p-S166,S188-MDM2 [nucleoplasm]

Inferred To

phospho-p-5S,T-MDM2 [nucleoplasm] (Bos taurus)

phospho-p-5S,T-MDM2 [nucleoplasm] (Caenorhabditis elegans)

phospho-p-5S,T-MDM2 [nucleoplasm] (Canis familiaris)

phospho-p-5S,T-MDM2 [nucleoplasm] (Danio rerio)

phospho-p-5S,T-MDM2 [nucleoplasm] (Drosophila melanogaster)

phospho-p-5S,T-MDM2 [nucleoplasm] (Gallus gallus)

phospho-p-5S,T-MDM2 [nucleoplasm] (Mus musculus)

phospho-p-5S,T-MDM2 [nucleoplasm] (Rattus norvegicus)

phospho-p-5S,T-MDM2 [nucleoplasm] (Schizosaccharomyces pombe)

phospho-p-5S,T-MDM2 [nucleoplasm] (Sus scrofa)

phospho-p-5S,T-MDM2 [nucleoplasm] (Xenopus tropicalis)

Homologues of p-5S,T-MDM2 [nucleoplasm] (Caenorhabditis elegans)

Modified Residues

Name

O-phospho-L-serine at 166

Coordinate

166

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 188

Coordinate

188

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 386

Coordinate

386

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 395

Coordinate

395

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 407

Coordinate

407

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 419

Coordinate

419

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_001138811.1, XP_006719462.1, XP_005268929.1, NP_002383.2, NP_001265391.1

ZINC - Investigational

MDM2_HUMAN

OpenTargets

ENSG00000135679

GeneCards

Q00987

ZINC - Substances

MDM2_HUMAN

ZINC target

Q00987

PRO

Q00987

Orphanet

21735

ZINC - Predictions - Purchasable

MDM2_HUMAN

HMDB Protein

HMDBP02432

PDB

5AFG, 3LBL, 2RUH, 2F1Y, 3LNJ, 3LBK, 4OGN, 6IM9, 4MDN, 6I3S, 3JZS, 4ZFI, 3JZR, 1T4F, 1RV1, 4OBA, 2AXI, 3W69, 5J7F, 2VJF, 4ODF, 2C6B, 4ERF, 4OAS, 5Z02, 2C6A, 3TJ2, 4ERE, 6Q9L, 3LNZ, 5HMI, 5SWK, 6Q9O, 4ZYC, 5LAZ, 4JV7, 4UD7, 2GV2, 4OGV, 4HBM, 2FOP, 2MPS, 3TU1, 4OGT, 1Z1M, 4JWR, 5HMH, 4JVR, 4UE1, 4HG7, 2LZG, 4QO4, 4XXB, 5MNJ, 3IUX, 4ZGK, 4OCC, 5UMM, 3V3B, 5VK0, 5C5A, 5WTS, 1YCR, 5OAI, 4DIJ, 4ODE, 4JVE, 4WT2, 4UMN, 1T4E, 2HDP, 3VBG, 5TRF, 3EQS, 5J7G, 2VJE, 3MQS, 6GGN, 4ZYI, 3IWY, 3JZK, 5XXK, 5LAY, 4OQ3, 3G03, 5HMK, 4JV9, 5ZXF, 4ZYF, 3TPX, 5LAV, 6Q9H, 4MDQ, 5LAW, 5LN2, 5OC8, 2M86, 6Q96, 4QOC, 4HFZ, 3VZV

Interactors (69)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.994	98
UniProt:Q93009 USP7	2	USP7 [nucleoplasm] (R-HSA-3215278) USP7 [cytosol] (R-HSA-8853511)	0.959	27
UniProt:O15151 MDM4	5	PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] (R-HSA-6804938) PolyUb-MDM4 [nucleoplasm] (R-HSA-6782502) p-S346,S367,S403-MDM4 [nucleoplasm] (R-HSA-349441) p-S403-MDM4 [nucleoplasm] (R-HSA-349461) MDM4 [nucleoplasm] (R-HSA-349430)	0.932	13
UniProt:P62913 RPL11	1	RPL11 [cytosol] (R-HSA-72406)	0.912	11
UniProt:Q9UER7 DAXX	2	DAXX [nucleoplasm] (R-HSA-3222068) SUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086)	0.895	18
UniProt:P31749 AKT1	13	p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356)	0.828	6
UniProt:P0CG48 UBC	316	UBC(533-608) [endocytic vesicle membrane] (R-HSA-939220) UBC(381-456) [endocytic vesicle membrane] (R-HSA-939218) UBC(609-684) [endocytic vesicle membrane] (R-HSA-939223) UBC(457-532) [endocytic vesicle membrane] (R-HSA-939195) UBC(153-228) [endocytic vesicle membrane] (R-HSA-939194) UBC(305-380) [endocytic vesicle membrane] (R-HSA-939228) UBC(229-304) [endocytic vesicle membrane] (R-HSA-939177) UBC(77-152) [endocytic vesicle membrane] (R-HSA-939210) UBC(1-76) [endocytic vesicle membrane] (R-HSA-939245) Ub-566-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783166) Ub-338-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783121) Ub-186-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783154) Ub-262-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783028) Ub-414-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783061) Ub-110-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783158) Ub-642-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783182) Ub-33-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783073) Ub-488-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783078) Ub-291-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783193) Ub-595-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783130) Ub-443-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783153) Ub-139-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783155) Ub-63-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783094) Ub-671-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783083) Ub-519-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783053) Ub-367-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783105) Ub-215-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783137) Ub-386-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783067) Ub-6-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783122) Ub-310-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783027) Ub-234-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783157) Ub-614-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783063) Ub-462-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783118) Ub-538-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783011) Ub-158-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783140) Ub-82-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783175) Ub-315-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783089) Ub-163-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783091) Ub-543-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783060) Ub-239-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783092) Ub-619-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783125) Ub-467-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783181) Ub-11-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783104) Ub-391-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783170) Ub-87-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783110) Ub-656-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783134) Ub-124-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783120) Ub-428-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783090) Ub-48-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783029) Ub-504-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783113) Ub-200-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783150) Ub-580-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783119) Ub-276-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783183) Ub-352-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783201) Ub-29-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783064) Ub-182-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783097) Ub-486-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783194) Ub-334-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783199) Ub-638-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783188) Ub-106-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783031) Ub-258-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783016) Ub-562-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783172) Ub-410-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783077) Ub-636-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783128) Ub-104-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783032) Ub-256-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783004) Ub-484-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783156) Ub-27-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783022) Ub-332-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783138) Ub-180-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783107) Ub-408-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783108) Ub-560-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783174) N6-glycyl-L-lysine-UBC(457-532) [cytosol] (R-HSA-8869048) N6-glycyl-L-lysine-UBC(609-684) [cytosol] (R-HSA-8869052) N6-glycyl-L-lysine-UBC(229-304) [cytosol] (R-HSA-8869032) N6-glycyl-L-lysine-UBC(533-608) [cytosol] (R-HSA-8869033) N6-glycyl-L-lysine-UBC(153-228) [cytosol] (R-HSA-8869035) N6-glycyl-L-lysine-UBC(305-380) [cytosol] (R-HSA-8869036) N6-glycyl-L-lysine-UBC(77-152) [cytosol] (R-HSA-8869026) N6-glycyl-L-lysine-UBC(1-76) [cytosol] (R-HSA-8869030) N6-glycyl-L-lysine-UBC(381-456) [cytosol] (R-HSA-8869031) Ub-29-UBC(1-76) [cytosol] (R-HSA-5689165) Ub-258-UBC(229-304) [cytosol] (R-HSA-5689167) Ub-334-UBC(305-380) [cytosol] (R-HSA-5689166) Ub-410-UBC(381-456) [cytosol] (R-HSA-5689185) Ub-486-UBC(457-532) [cytosol] (R-HSA-5689176) Ub-562-UBC(533-608) [cytosol] (R-HSA-5689151) Ub-106-UBC(77-152) [cytosol] (R-HSA-5689183) Ub-182-UBC(153-228) [cytosol] (R-HSA-5689169) Ub-638-UBC(609-684) [cytosol] (R-HSA-5689136) Ub-310-UBC(305-380) [cytosol] (R-HSA-5689097) Ub-6-UBC(1-76) [cytosol] (R-HSA-5689091) Ub-462-UBC(457-532) [cytosol] (R-HSA-5689092) Ub-386-UBC(381-456) [cytosol] (R-HSA-5689086) Ub-538-UBC(533-608) [cytosol] (R-HSA-5689104) Ub-158-UBC(153-228) [cytosol] (R-HSA-5689107) Ub-614-UBC(609-684) [cytosol] (R-HSA-5689076) Ub-234-UBC(229-304) [cytosol] (R-HSA-5689110) Ub-82-UBC(77-152) [cytosol] (R-HSA-5689078) Ub-110-UBC(77-152) [cytosol] (R-HSA-5689196) Ub-33-UBC(1-76) [cytosol] (R-HSA-5689134) Ub-488-UBC(457-532) [cytosol] (R-HSA-5689153) Ub-338-UBC(305-380) [cytosol] (R-HSA-5689152) Ub-642-UBC(609-684) [cytosol] (R-HSA-5689218) Ub-414-UBC(381-456) [cytosol] (R-HSA-5689157) Ub-262-UBC(229-304) [cytosol] (R-HSA-5689150) Ub-566-UBC(533-608) [cytosol] (R-HSA-5689205) Ub-186-UBC(153-228) [cytosol] (R-HSA-5689140) adenylatedG608-UBC(533-608) [nucleoplasm] (R-HSA-8852090) adenylatedG380-UBC(305-380) [nucleoplasm] (R-HSA-8852093) adenylatedG532-UBC(457-532) [nucleoplasm] (R-HSA-8852081) adenylatedG304-UBC(229-304) [nucleoplasm] (R-HSA-8852050) adenylatedG152-UBC(77-152) [nucleoplasm] (R-HSA-8852054) adenylatedG684-UBC(609-684) [nucleoplasm] (R-HSA-8852105) adenylatedG228-UBC(153-228) [nucleoplasm] (R-HSA-8852075) adenylatedG76-UBC(1-76) [nucleoplasm] (R-HSA-8852044) adenylatedG456-UBC(381-456) [nucleoplasm] (R-HSA-8852098) UBC [cytosol] (R-HSA-8853531) adenylatedG380-UBC(305-380) [cytosol] (R-HSA-8852062) adenylatedG608-UBC(533-608) [cytosol] (R-HSA-8852052) adenylatedG76-UBC(1-76) [cytosol] (R-HSA-8852053) adenylatedG304-UBC(229-304) [cytosol] (R-HSA-8852117) adenylatedG684-UBC(609-684) [cytosol] (R-HSA-8852118) adenylatedG152-UBC(77-152) [cytosol] (R-HSA-8852087) adenylatedG532-UBC(457-532) [cytosol] (R-HSA-8852045) adenylatedG228-UBC(153-228) [cytosol] (R-HSA-8852111) adenylatedG456-UBC(381-456) [cytosol] (R-HSA-8852069) Ub-428-UBC(381-456) [endoplasmic reticulum membrane] (R-HSA-8943062) Ub-656-UBC(609-684) [endoplasmic reticulum membrane] (R-HSA-8943120) Ub-124-UBC(77-152) [endoplasmic reticulum membrane] (R-HSA-8943129) Ub-48-UBC(1-76) [endoplasmic reticulum membrane] (R-HSA-8943079) Ub-352-UBC(305-380) [endoplasmic reticulum membrane] (R-HSA-8943108) Ub-504-UBC(457-532) [endoplasmic reticulum membrane] (R-HSA-8943075) Ub-276-UBC(229-304) [endoplasmic reticulum membrane] (R-HSA-8943106) Ub-580-UBC(533-608) [endoplasmic reticulum membrane] (R-HSA-8943137) Ub-200-UBC(153-228) [endoplasmic reticulum membrane] (R-HSA-8943087) UBC(77-152) [endoplasmic reticulum membrane] (R-HSA-8943095) UBC(381-456) [endoplasmic reticulum membrane] (R-HSA-8943126) UBC(533-608) [endoplasmic reticulum membrane] (R-HSA-8943061) UBC(609-684) [endoplasmic reticulum membrane] (R-HSA-8943135) UBC(229-304) [endoplasmic reticulum membrane] (R-HSA-8943103) UBC(153-228) [endoplasmic reticulum membrane] (R-HSA-8943068) UBC(1-76) [endoplasmic reticulum membrane] (R-HSA-8943077) UBC(305-380) [endoplasmic reticulum membrane] (R-HSA-8943084) UBC(457-532) [endoplasmic reticulum membrane] (R-HSA-8943112) UBC(1-76) [plasma membrane] (R-HSA-3149469) UBC(457-532) [plasma membrane] (R-HSA-3149468) UBC(153-228) [plasma membrane] (R-HSA-3149467) UBC(609-684) [plasma membrane] (R-HSA-3149466) UBC(77-152) [plasma membrane] (R-HSA-3149465) UBC(229-304) [plasma membrane] (R-HSA-3149464) UBC(533-608) [plasma membrane] (R-HSA-3149462) UBC(381-456) [plasma membrane] (R-HSA-3149459) UBC(305-380) [plasma membrane] (R-HSA-3149458) UBC(1-76) [endosome membrane] (R-HSA-939187) UBC(533-608) [endosome membrane] (R-HSA-939221) UBC(77-152) [endosome membrane] (R-HSA-939161) UBC(305-380) [endosome membrane] (R-HSA-939196) UBC(457-532) [endosome membrane] (R-HSA-939199) UBC(381-456) [endosome membrane] (R-HSA-939166) UBC(153-228) [endosome membrane] (R-HSA-939170) UBC(609-684) [endosome membrane] (R-HSA-939237) UBC(229-304) [endosome membrane] (R-HSA-939172) Ub-256-UBC(229-304) [cytosol] (R-HSA-5689135) Ub-180-UBC(153-228) [cytosol] (R-HSA-5689221) Ub-104-UBC(77-152) [cytosol] (R-HSA-5689189) Ub-484-UBC(457-532) [cytosol] (R-HSA-5689220) Ub-560-UBC(533-608) [cytosol] (R-HSA-5689145) Ub-636-UBC(609-684) [cytosol] (R-HSA-5689144) Ub-332-UBC(305-380) [cytosol] (R-HSA-5689211) Ub-27-UBC(1-76) [cytosol] (R-HSA-5689179) Ub-408-UBC(381-456) [cytosol] (R-HSA-5689182) Ub-87-UBC(77-152) [cytosol] (R-HSA-3095920) Ub-163-UBC(153-228) [cytosol] (R-HSA-3095924) Ub-619-UBC(609-684) [cytosol] (R-HSA-3095925) Ub-467-UBC(457-532) [cytosol] (R-HSA-3095935) Ub-11-UBC(1-76) [cytosol] (R-HSA-3095906) Ub-543-UBC(533-608) [cytosol] (R-HSA-3095912) Ub-391-UBC(381-456) [cytosol] (R-HSA-3095914) Ub-315-UBC(305-380) [cytosol] (R-HSA-3095916) Ub-239-UBC(229-304) [cytosol] (R-HSA-3095919) Ub-519-UBC(457-532) [endosome membrane] (R-HSA-939227) Ub-367-UBC(305-380) [endosome membrane] (R-HSA-939162) Ub-291-UBC(229-304) [endosome membrane] (R-HSA-939226) Ub-443-UBC(381-456) [endosome membrane] (R-HSA-939204) Ub-215-UBC(153-228) [endosome membrane] (R-HSA-939175) Ub-63-UBC(1-76) [endosome membrane] (R-HSA-939174) Ub-595-UBC(533-608) [endosome membrane] (R-HSA-939242) Ub-139-UBC(77-152) [endosome membrane] (R-HSA-939244) Ub-671-UBC(609-684) [endosome membrane] (R-HSA-939183) Ub-291-UBC(229-304) [plasma membrane] (R-HSA-939859) Ub-595-UBC(533-608) [plasma membrane] (R-HSA-939858) Ub-367-UBC(305-380) [plasma membrane] (R-HSA-939861) Ub-63-UBC(1-76) [plasma membrane] (R-HSA-939860) Ub-139-UBC(77-152) [plasma membrane] (R-HSA-939865) Ub-215-UBC(153-228) [plasma membrane] (R-HSA-939864) Ub-519-UBC(457-532) [plasma membrane] (R-HSA-939845) Ub-671-UBC(609-684) [plasma membrane] (R-HSA-939846) Ub-443-UBC(381-456) [plasma membrane] (R-HSA-939848) Ub-408-UBC(381-456) [nucleoplasm] (R-HSA-6782681) Ub-484-UBC(457-532) [nucleoplasm] (R-HSA-6782650) Ub-104-UBC(77-152) [nucleoplasm] (R-HSA-6782651) Ub-256-UBC(229-304) [nucleoplasm] (R-HSA-6782641) Ub-180-UBC(153-228) [nucleoplasm] (R-HSA-6782603) Ub-560-UBC(533-608) [nucleoplasm] (R-HSA-6782637) Ub-27-UBC(1-76) [nucleoplasm] (R-HSA-6782625) Ub-636-UBC(609-684) [nucleoplasm] (R-HSA-6782597) Ub-332-UBC(305-380) [nucleoplasm] (R-HSA-6782630) Ub-638-UBC(609-684) [nucleoplasm] (R-HSA-6782680) Ub-258-UBC(229-304) [nucleoplasm] (R-HSA-6782621) Ub-562-UBC(533-608) [nucleoplasm] (R-HSA-6782672) Ub-410-UBC(381-456) [nucleoplasm] (R-HSA-6782642) Ub-182-UBC(153-228) [nucleoplasm] (R-HSA-6782678) Ub-106-UBC(77-152) [nucleoplasm] (R-HSA-6782602) Ub-334-UBC(305-380) [nucleoplasm] (R-HSA-6782638) Ub-29-UBC(1-76) [nucleoplasm] (R-HSA-6782659) Ub-486-UBC(457-532) [nucleoplasm] (R-HSA-6782661) Ub-671-UBC(609-684) [nucleoplasm] (R-HSA-6782523) Ub-215-UBC(153-228) [nucleoplasm] (R-HSA-6782491) Ub-63-UBC(1-76) [nucleoplasm] (R-HSA-6782492) Ub-443-UBC(381-456) [nucleoplasm] (R-HSA-6782480) Ub-367-UBC(305-380) [nucleoplasm] (R-HSA-6782479) Ub-139-UBC(77-152) [nucleoplasm] (R-HSA-6782496) Ub-519-UBC(457-532) [nucleoplasm] (R-HSA-6782497) Ub-595-UBC(533-608) [nucleoplasm] (R-HSA-6782499) Ub-291-UBC(229-304) [nucleoplasm] (R-HSA-6782500) Ub-48-UBC(1-76) [nucleoplasm] (R-HSA-6782524) Ub-428-UBC(381-456) [nucleoplasm] (R-HSA-6782462) Ub-504-UBC(457-532) [nucleoplasm] (R-HSA-6782512) Ub-276-UBC(229-304) [nucleoplasm] (R-HSA-6782482) Ub-200-UBC(153-228) [nucleoplasm] (R-HSA-6782487) Ub-656-UBC(609-684) [nucleoplasm] (R-HSA-6782474) Ub-580-UBC(533-608) [nucleoplasm] (R-HSA-6782477) Ub-124-UBC(77-152) [nucleoplasm] (R-HSA-6782498) Ub-352-UBC(305-380) [nucleoplasm] (R-HSA-6782467) Ub-467-UBC(457-532) [nucleoplasm] (R-HSA-6782619) Ub-163-UBC(153-228) [nucleoplasm] (R-HSA-6782622) Ub-11-UBC(1-76) [nucleoplasm] (R-HSA-6782609) Ub-87-UBC(77-152) [nucleoplasm] (R-HSA-6782632) Ub-239-UBC(229-304) [nucleoplasm] (R-HSA-6782669) Ub-543-UBC(533-608) [nucleoplasm] (R-HSA-6782594) Ub-391-UBC(381-456) [nucleoplasm] (R-HSA-6782626) Ub-315-UBC(305-380) [nucleoplasm] (R-HSA-6782660) Ub-619-UBC(609-684) [nucleoplasm] (R-HSA-6782662) Ub-186-UBC(153-228) [nucleoplasm] (R-HSA-6782617) Ub-338-UBC(305-380) [nucleoplasm] (R-HSA-6782620) Ub-33-UBC(1-76) [nucleoplasm] (R-HSA-6782653) Ub-110-UBC(77-152) [nucleoplasm] (R-HSA-6782590) Ub-262-UBC(229-304) [nucleoplasm] (R-HSA-6782640) Ub-642-UBC(609-684) [nucleoplasm] (R-HSA-6782674) Ub-566-UBC(533-608) [nucleoplasm] (R-HSA-6782646) Ub-414-UBC(381-456) [nucleoplasm] (R-HSA-6782636) Ub-488-UBC(457-532) [nucleoplasm] (R-HSA-6782599) Ub-82-UBC(77-152) [nucleoplasm] (R-HSA-6782675) Ub-6-UBC(1-76) [nucleoplasm] (R-HSA-6782611) Ub-234-UBC(229-304) [nucleoplasm] (R-HSA-6782677) Ub-158-UBC(153-228) [nucleoplasm] (R-HSA-6782645) Ub-310-UBC(305-380) [nucleoplasm] (R-HSA-6782614) Ub-538-UBC(533-608) [nucleoplasm] (R-HSA-6782664) Ub-462-UBC(457-532) [nucleoplasm] (R-HSA-6782634) Ub-386-UBC(381-456) [nucleoplasm] (R-HSA-6782605) Ub-614-UBC(609-684) [nucleoplasm] (R-HSA-6782657) UBC(229-304) [nucleoplasm] (R-HSA-939857) UBC(381-456) [nucleoplasm] (R-HSA-939856) UBC(305-380) [nucleoplasm] (R-HSA-939863) UBC(457-532) [nucleoplasm] (R-HSA-939862) UBC(533-608) [nucleoplasm] (R-HSA-939866) UBC(77-152) [nucleoplasm] (R-HSA-939869) UBC(609-684) [nucleoplasm] (R-HSA-939868) UBC(1-76) [nucleoplasm] (R-HSA-939871) UBC(153-228) [nucleoplasm] (R-HSA-939853) Ub-124-UBC(77-152) [nucleoplasm] (R-HSA-5683048) Ub-580-UBC(533-608) [nucleoplasm] (R-HSA-5683050) Ub-428-UBC(381-456) [nucleoplasm] (R-HSA-5683041) Ub-276-UBC(229-304) [nucleoplasm] (R-HSA-5683042) Ub-352-UBC(305-380) [nucleoplasm] (R-HSA-5683045) Ub-200-UBC(153-228) [nucleoplasm] (R-HSA-5683046) Ub-48-UBC(1-76) [nucleoplasm] (R-HSA-5683033) Ub-656-UBC(609-684) [nucleoplasm] (R-HSA-5683035) Ub-504-UBC(457-532) [nucleoplasm] (R-HSA-5683039) Ub-671-UBC(609-684) [nucleoplasm] (R-HSA-5682857) Ub-139-UBC(77-152) [nucleoplasm] (R-HSA-5682856) Ub-519-UBC(457-532) [nucleoplasm] (R-HSA-5682848) Ub-63-UBC(1-76) [nucleoplasm] (R-HSA-5682852) Ub-595-UBC(533-608) [nucleoplasm] (R-HSA-5682841) Ub-215-UBC(153-228) [nucleoplasm] (R-HSA-5682840) Ub-443-UBC(381-456) [nucleoplasm] (R-HSA-5682843) Ub-291-UBC(229-304) [nucleoplasm] (R-HSA-5682842) Ub-367-UBC(305-380) [nucleoplasm] (R-HSA-5682837) Ub-48-UBC(1-76) [cytosol] (R-HSA-939219) Ub-656-UBC(609-684) [cytosol] (R-HSA-939255) Ub-428-UBC(381-456) [cytosol] (R-HSA-939190) Ub-504-UBC(457-532) [cytosol] (R-HSA-939257) Ub-580-UBC(533-608) [cytosol] (R-HSA-939256) Ub-276-UBC(229-304) [cytosol] (R-HSA-939207) Ub-124-UBC(77-152) [cytosol] (R-HSA-939209) Ub-200-UBC(153-228) [cytosol] (R-HSA-939179) Ub-352-UBC(305-380) [cytosol] (R-HSA-939181) UBC(457-532) [cytosol] (R-HSA-939184) UBC(1-76) [cytosol] (R-HSA-939188) UBC(381-456) [cytosol] (R-HSA-939191) UBC(229-304) [cytosol] (R-HSA-939192) UBC(153-228) [cytosol] (R-HSA-939258) UBC(609-684) [cytosol] (R-HSA-939165) UBC(77-152) [cytosol] (R-HSA-939164) UBC(305-380) [cytosol] (R-HSA-939232) UBC(533-608) [cytosol] (R-HSA-939239) Ub-215-UBC(153-228) [cytosol] (R-HSA-939186) Ub-139-UBC(77-152) [cytosol] (R-HSA-939254) Ub-595-UBC(533-608) [cytosol] (R-HSA-939198) Ub-291-UBC(229-304) [cytosol] (R-HSA-939173) Ub-367-UBC(305-380) [cytosol] (R-HSA-939206) Ub-671-UBC(609-684) [cytosol] (R-HSA-939241) Ub-63-UBC(1-76) [cytosol] (R-HSA-939176) Ub-519-UBC(457-532) [cytosol] (R-HSA-939212) Ub-443-UBC(381-456) [cytosol] (R-HSA-939182)	0.821	6
UniProt:Q8N726 CDKN2A	12	p14ARF [cytosol] (R-HSA-9645669) p14ARF [nucleoplasm] (R-HSA-1629813) p14ARF [mitochondrial matrix] (R-HSA-9645695) p14ARF R98L;R99S [cytosol] (R-HSA-9645730) p14ARF R82C [cytosol] (R-HSA-9645750) p14ARF R90H [cytosol] (R-HSA-9645755) p14ARF R88Q [cytosol] (R-HSA-9645754) p14ARF R87C [cytosol] (R-HSA-9645759) p14ARF R81G [cytosol] (R-HSA-9645741) p14ARF R98Q [cytosol] (R-HSA-9645757) p14ARF R99C [cytosol] (R-HSA-9645756) p14ARF R21RfsTER47 [cytosol] (R-HSA-9646285)	0.813	5
UniProt:P62081 RPS7	2	RPS7 [cytosol] (R-HSA-72383) RPS7 [nucleoplasm] (R-HSA-6790635)	0.75	15
UniProt:Q00987 MDM2	11	SUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.736	4
UniProt:P06400 RB1	3	p-S795-RB1 [nucleoplasm] (R-HSA-69226) RB1 [nucleoplasm] (R-HSA-68642) p-RB1 [nucleoplasm] (R-HSA-188389)	0.734	5
UniProt:P19338 NCL	1	NCL [nucleoplasm] (R-HSA-6791213)	0.71	8
UniProt:P68104 EEF1A1	7	Me3K318-EEF1A1 [cytosol] (R-HSA-8932419) Me3K79-EEF1A1 [cytosol] (R-HSA-8932212) EEF1A1 [secretory granule lumen] (R-HSA-6801479) EEF1A1 [extracellular region] (R-HSA-6806456) EEF1A1 [ficolin-1-rich granule lumen] (R-HSA-6801528) EEF1A1 [cytosol] (R-HSA-156905) EEF1A1 [lysosomal membrane] (R-HSA-9626022)	0.709	9
UniProt:P32121 ARRB2	2	PolyUb-ARRB2 [cytosol] (R-HSA-6783000) ARRB2 [cytosol] (R-HSA-416464)	0.708	5
UniProt:P06748 NPM1	5	p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [cytosol] (R-HSA-3008211) NPM1 [nucleoplasm] (R-HSA-606320) SUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) SUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.697	5
UniProt:P23396 RPS3	2	RPS3 [cytosol] (R-HSA-72369) RPS3 [nucleoplasm] (R-HSA-6798714)	0.696	8
UniProt:P29067	2	ARRB2 [cytosol] (R-RNO-416464) PolyUb-ARRB2 [cytosol] (R-RNO-6783000)	0.688	4
UniProt:P46777 RPL5	1	RPL5 [cytosol] (R-HSA-72482)	0.669	5
UniProt:O96017 CHEK2	3	p-T68-CHEK2 [nucleoplasm] (R-HSA-113825) p-S,3T-CHEK2 [nucleoplasm] (R-HSA-5683784) CHEK2 [nucleoplasm] (R-HSA-113824)	0.66	6
UniProt:P49407 ARRB1	5	PolyUb-ARRB1 [cytosol] (R-HSA-6783186) ARRB1 [cytosol] (R-HSA-264470) ARRB1 [lysosomal membrane] (R-HSA-432701) ARRB1 [Golgi membrane] (R-HSA-350831) ARRB1 [cytoplasmic vesicle membrane] (R-HSA-351187)	0.641	3
UniProt:Q96FW1 OTUB1	2	OTUB1 [cytosol] (R-HSA-933411) OTUB1 [nucleoplasm] (R-HSA-6783242)	0.632	5
UniProt:P49757 NUMB	1	NUMB [plasma membrane] (R-HSA-443595)	0.623	6
UniProt:Q9H2X6 HIPK2	3	HIPK2 [nucleoplasm] (R-HSA-3215222) p-HIPK2 [nucleoplasm] (R-HSA-6799375) SUMO1-K32-HIPK2 [nucleoplasm] (R-HSA-4090405)	0.62	5
UniProt:Q71UM5 RPS27L	2	RPS27L [cytosol] (R-HSA-8868849) RPS27L [nucleoplasm] (R-HSA-6791197)	0.619	6
IntAct:EBI-15762335 PMI			0.618	3
UniProt:Q8N488 RYBP	1	RYBP [nucleoplasm] (R-HSA-8937975)	0.616	11
UniProt:P61289 PSME3	2	PSME3 [cytosol] (R-HSA-68816) PSME3 [nucleoplasm] (R-HSA-174310)	0.612	8
UniProt:P26447 S10A4			0.611	3
UniProt:P48730 CSNK1D	3	CSNK1D [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5685717) CSNK1D [nucleoplasm] (R-HSA-421305) CSNK1D [cytosol] (R-HSA-380315)	0.61	6
UniProt:P42574 CASP3	5	CASP3(176-277) [nucleoplasm] (R-HSA-211203) CASP3(29-175) [nucleoplasm] (R-HSA-211194) CASP3(1-277) [cytosol] (R-HSA-57021) CASP3(29-175) [cytosol] (R-HSA-141644) CASP3(176-277) [cytosol] (R-HSA-141646)	0.609	2
UniProt:P29590 PML	5	SUMO2-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000423) SUMO3-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000386) SUMO1-K65,160,490-PML [nucleoplasm] (R-HSA-3000440) PML [nucleoplasm] (R-HSA-1031706) PML [cytosol] (R-HSA-5624327)	0.609	6
IntAct:EBI-4399559 UBIQ			0.609	2
UniProt:P42677 RPS27	2	RPS27 [cytosol] (R-HSA-72361) RPS27 [nucleoplasm] (R-HSA-6791190)	0.602	5
UniProt:P53350 PLK1	4	p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) PLK1 [nucleoplasm] (R-HSA-156720) p-T210-PLK1 [cytosol] (R-HSA-3000318) PLK1 [cytosol] (R-HSA-164603)	0.602	7
UniProt:Q9Y297 BTRC	2	BTRC [nucleoplasm] (R-HSA-3361753) BTRC [cytosol] (R-HSA-174237)	0.591	9
UniProt:P08069 IGF1R	3	IGF1R(31-736) [plasma membrane] (R-HSA-2404169) IGF1R(741-1367) [plasma membrane] (R-HSA-2404180) p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane] (R-HSA-2404172)	0.589	2
UniProt:P61978 HNRNPK	2	SUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532) HNRNPK [nucleoplasm] (R-HSA-71945)	0.589	2
UniProt:P29590-5 PML			0.582	6
UniProt:P62829 RPL23	1	RPL23 [cytosol] (R-HSA-72430)	0.573	3
UniProt:O15350 TP73	3	TP73 [cytosol] (R-HSA-8957239) PolyUb-TP73 [cytosol] (R-HSA-8957256) TP73 [nucleoplasm] (R-HSA-6798094)	0.558	4
UniProt:P23297 S100A1	1	S100A1 [extracellular region] (R-HSA-6805991)	0.558	2
UniProt:P29034 S10A2			0.558	2
UniProt:Q13362 PPP2R5C	3	p-S337-PPP2R5C [cytosol] (R-HSA-6811447) PPP2R5C [nucleoplasm] (R-HSA-3008946) PPP2R5C [cytosol] (R-HSA-3008954)	0.558	5
UniProt:P06703 S10A6			0.558	2
UniProt:P04271 S100B	1	S100B [extracellular region] (R-HSA-879433)	0.558	2
UniProt:Q9NVN8 GNL3L			0.556	8
UniProt:O15297 PPM1D	1	PPM1D [nucleoplasm] (R-HSA-2562518)	0.544	4
UniProt:P60866 RPS20	2	RPS20 [nucleoplasm] (R-HSA-6798727) RPS20 [cytosol] (R-HSA-72349)	0.527	2
UniProt:P78352 DLG4	3	DLG4 [cytosol] (R-HSA-6794267) DLG4 [plasma membrane] (R-HSA-202135) DLG4 [endocytic vesicle membrane] (R-HSA-416847)	0.525	3
UniProt:P17535 JUND	1	JUND [nucleoplasm] (R-HSA-9009924)	0.524	3
UniProt:Q9UKB1 FBXW11	1	FBXW11 [cytosol] (R-HSA-976035)	0.524	4
UniProt:Q2HR73 VIRF4			0.524	2
UniProt:P48729-2 CSNK1A1			0.524	3
UniProt:Q15648 MED1	1	MED1 [nucleoplasm] (R-HSA-212445)	0.524	3
UniProt:Q92736 RYR2	1	RYR2 [sarcoplasmic reticulum membrane] (R-HSA-937283)	0.524	2
UniProt:Q5T7V8 GORAB			0.524	6
UniProt:Q15466 NR0B2	1	NR0B2 [nucleoplasm] (R-HSA-376312)	0.524	4
UniProt:P48729 CSNK1A1	2	CSNK1A1 [cytosol] (R-HSA-195263) CSNK1A1 [cilium] (R-HSA-5632507)	0.524	3
UniProt:P49674 CSNK1E	2	CSNK1E [nucleoplasm] (R-HSA-421306) CSNK1E [cytosol] (R-HSA-205877)	0.524	3
UniProt:Q13616 CUL1	3	CUL1 [cytosol] (R-HSA-174230) G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519) CUL1 [nucleoplasm] (R-HSA-187551)	0.524	3
UniProt:P05412 JUN	4	p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [nucleoplasm] (R-HSA-450250) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.524	3
UniProt:P15311 EZR	3	p-T567-EZR [cytosol] (R-HSA-374559) EZR [cytosol] (R-HSA-9020826) p-Y146,Y354-EZR [cytosol] (R-HSA-374572)	0.524	3
UniProt:Q00688 FKBP3			0.508	2
UniProt:P03372 ESR1	8	SUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.508	2
UniProt:Q6PCD5 RFWD3			0.499	2
UniProt:Q9NS23 RASF1			0.499	5
UniProt:Q6P5F9	2	XPO1 [cytosol] (R-MMU-165539) XPO1 [nucleoplasm] (R-MMU-165529)	0.499	4
UniProt:Q13362-1 PPP2R5C			0.499	3
IntAct:EBI-1800051 CDKN1A			0.462	2