Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
p-S166,S188-MDM2 dimer [nucleoplasm]
Stable Identifier
R-HSA-6804933
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
G1/S DNA Damage Checkpoints (Homo sapiens)
p53-Dependent G1/S DNA damage checkpoint (Homo sapiens)
p53-Dependent G1 DNA Damage Response (Homo sapiens)
Stabilization of p53 (Homo sapiens)
MDM2 binds TP53 (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
MDM2 forms homo- or heterodimers (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
MDM2 ubiquitinates TP53 (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
Cellular responses to external stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Oncogene Induced Senescence (Homo sapiens)
MDM2 ubiquitinates TP53 (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p14ARF forms a ternary complex with MDM2 and TP53 (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p14ARF sequesters MDM2 (Homo sapiens)
p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
MDM2 ubiquitinates TP53 (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p14ARF forms a ternary complex with MDM2 and TP53 (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p14ARF sequesters MDM2 (Homo sapiens)
p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Activity through Methylation (Homo sapiens)
MDM2 ubiquitinates JMY (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
MDM2 ubiquitinates DYRK2 (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
Regulation of TP53 Expression and Degradation (Homo sapiens)
Regulation of TP53 Degradation (Homo sapiens)
MDM2 binds TP53 (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
MDM2 forms homo- or heterodimers (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
MDM2 homodimers auto-ubiquitinate (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
MDM2 ubiquitinates TP53 (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
USP7 deubiquitinates MDM2 (Homo sapiens)
p-S166,S188-MDM2:(p-S166,S188-MDM2,p-S346,S367,S403-MDM4) [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p14ARF forms a ternary complex with MDM2 and TP53 (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p14ARF sequesters MDM2 (Homo sapiens)
p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
Regulation of RUNX3 expression and activity (Homo sapiens)
MDM2 binds RUNX3 (Homo sapiens)
RUNX3:p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
MDM2 polyubiquitinates RUNX3 (Homo sapiens)
RUNX3:p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
21986495
Regulation of MDM2 E3 ligase activity by phosphorylation after DNA damage
Cheng, Q
,
Cross, B
,
Li, B
,
Chen, L
,
Li, Z
,
Chen, J
Mol. Cell. Biol.
2011
Participants
components
2 x
p-S166,S188-MDM2 [nucleoplasm] (Homo sapiens)
Participant Of
input
MDM2 binds RUNX3
MDM2 homodimers auto-ubiquitinate
output
MDM2 polyubiquitinates RUNX3
hasComponent
RUNX3:p-S166,S188-MDM2 dimer [nucleoplasm]
hasMember
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm]
p-S166,S188-MDM2:(p-S166,S188-MDM2,p-S346,S367,S403-MDM4) [nucleoplasm]
Inferred To
p-S166,S188-MDM2 dimer [nucleoplasm] (Bos taurus)
p-S166,S188-MDM2 dimer [nucleoplasm] (Caenorhabditis elegans)
p-S166,S188-MDM2 dimer [nucleoplasm] (Canis familiaris)
p-S166,S188-MDM2 dimer [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2 dimer [nucleoplasm] (Drosophila melanogaster)
p-S166,S188-MDM2 dimer [nucleoplasm] (Gallus gallus)
p-S166,S188-MDM2 dimer [nucleoplasm] (Mus musculus)
p-S166,S188-MDM2 dimer [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2 dimer [nucleoplasm] (Schizosaccharomyces pombe)
p-S166,S188-MDM2 dimer [nucleoplasm] (Sus scrofa)
p-S166,S188-MDM2 dimer [nucleoplasm] (Xenopus tropicalis)
© 2019
Reactome