PIAS1 SUMOylates L3MBTL2 with SUMO2

Stable Identifier
R-HSA-6804485
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PIAS1 and possibly other SUMO E3 ligases SUMOylates L3MBTL2 with SUMO2 at lysine-675 and lysine-700 near the C-terminus (Stielow et al. 2014, Tammsalu et al. 2014). SUMOylation of L3MBTL2 does not appear to affect its chromatin binding activity, however SUMOylation does enhance transcriptional repression of a subset of L3MBTL2-target genes, particularly those with low L3MBTL2 occupancy including pro-inflammatory genes (Stielow et al. 2014). SUMOylated L3MBTL2 appears to increase the level of local ubiquitinated histone H2A (Stielow et al. 2014).

Literature References
PubMed ID Title Journal Year
24369422 SUMOylation of the polycomb group protein L3MBTL2 facilitates repression of its target genes

Stielow, C, Stielow, B, Finkernagel, F, Scharfe, M, Jarek, M, Suske, G

Nucleic Acids Res. 2014
24782567 Proteome-wide identification of SUMO2 modification sites

Tammsalu, T, Matic, I, Jaffray, EG, Ibrahim, AF, Tatham, MH, Hay, RT

Sci Signal 2014
Participants
Participant Of
Event Information
Go Biological Process
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of PIAS1 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created