CLCN6(1-49)-RAF1(279-648) fusion [cytosol]

Stable Identifier
R-HSA-6802288
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
25204415 The landscape of kinase fusions in cancer

Kim, JL, Schalm, S, Stransky, N, Lengauer, C, Cerami, E

Nat Commun 2014
External Reference Information
External Reference
UniProt:P51797 CLCN6
Gene Names
CLCN6, KIAA0046
Chain
chain:1-869
Reference Genes
BioGPS Gene:1185 CLCN6
COSMIC (genes):CLCN6 CLCN6
CTD Gene:1185 CLCN6
dbSNP Gene:1185 CLCN6
ENSEMBL:ENSG00000011021 CLCN6
ENSEMBL_homo_sapiens_GENE:ENSG00000011021.23 CLCN6
HGNC:2024 CLCN6
KEGG Gene (Homo sapiens):1185 CLCN6
Monarch:1185 CLCN6
NCBI Gene:1185 CLCN6
OMIM:602726 CLCN6
UCSC:P51797 CLCN6
Reference Transcript
Other Identifiers
11715208_s_at
11720434_at
11720435_s_at
11720436_a_at
11743239_a_at
11750628_a_at
1185
16659102
16659133
203950_PM_s_at
203950_s_at
2320473
2320474
2320475
2320476
2320477
2320482
2320483
2320486
2320488
2320494
2320495
2320496
2320497
2320498
2320499
2320500
2320501
2320502
2320508
2320510
2320512
2320513
2320514
2320515
2320516
2320518
2320519
2320520
2320521
2320522
2320524
2320525
2320526
2320527
2320528
2320529
2320530
2320531
2320532
34200_at
7897774
A_14_P115457
A_14_P139620
A_24_P302374
A_33_P3415113
GE62379
GO:0000166
GO:0005215
GO:0005247
GO:0005524
GO:0005764
GO:0005765
GO:0005768
GO:0005773
GO:0006811
GO:0006821
GO:0006884
GO:0007165
GO:0009612
GO:0010008
GO:0015108
GO:0015297
GO:0016020
GO:0023052
GO:0031410
GO:0031902
GO:0034220
GO:0043226
GO:0043231
GO:0055085
GO:1902476
HMNXSV003028442
HMNXSV003044994
ILMN_1741594
ILMN_1763036
ILMN_1808748
PH_hs_0028254
PH_hs_0030766
TC01000149.hg
TC01004184.hg
X83378_at
g4502872_3p_a_at
Participates
as a component of
Other forms of this molecule
CLCN6 [endosome membrane]
CLCN6(1-49)-p-RAF1(279-648) fusion [cytosol]
Modified Residues
Name
Insertion of residues 279 to 648 at 50 from UniProt:P04049 RAF1
Coordinate
50
Name
O-phospho-L-serine at 621
Coordinate
621
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
skin melanoma DOID:8923 malignant lip melanoma, malignant ear melanoma, malignant melanoma of ear and/or external auricular canal, cutaneous melanoma, malignant melanoma of skin of trunk except scrotum, malignant neck melanoma, malignant melanoma of skin of upper limb, malignant scalp melanoma, malignant upper limb melanoma, malignant lower limb melanoma, malignant melanoma of skin of lower limb, malignant trunk melanoma
Cross References
RefSeq
Guide to Pharmacology - Targets
705
OpenTargets
GeneCards
HPA
Ensembl
PRO
Pharos - Targets
PDB
HMDB Protein
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