TP53 stimulates PLK2 expression

Stable Identifier
R-HSA-6801637
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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TP53 stimulates PLK2 expression
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Binding of TP53 to p53 binding site(s) in the promoter of the PLK2 gene stimulates PLK2 transcription. PLK2 may be involved in prevention of the mitotic catastrophe after spindle damage (Burns et al. 2003). PLK2 is frequently transcriptionally silenced through promoter methylation in B-cell malignancies (Syed et al. 2006).
Literature References
PubMed ID Title Journal Year
16160013 Transcriptional silencing of Polo-like kinase 2 (SNK/PLK2) is a frequent event in B-cell malignancies

Karran, L, Hoffmann, I, Smith, P, Sullivan, A, Griffin, B, Allday, M, Spender, LC, Syed, N, Dyer, M, Crawford, D, O'Nions, J, Farrell, PJ, Crook, T

Blood 2006
12897130 Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells

Dicker, DT, Scata, KA, Fei, P, Burns, TF, El-Deiry, WS

Mol. Cell. Biol. 2003
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-S15,S20-TP53 Tetramer:PLK2 Gene [nucleoplasm] (Homo sapiens)
Active Unit
p-S15,S20-TP53 Tetramer [nucleoplasm]
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-10-02)
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