Reactome | PLK2 [cytosol]

PLK2 [cytosol]

Stable Identifier

R-HSA-6801636

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Serine/threonine-protein kinase PLK2, Polo-like kinase 2, Serine/threonine-protein kinase SNK, SNK

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Leishmania parasite growth and survival (Homo sapiens)
        
        Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
        
        CD163 mediating an anti-inflammatory response (Homo sapiens)
        
        PLK2, MAPK14 phosphorylate ADAM17 (Homo sapiens)
        
        PLK2, MAPK14 [cytosol] (Homo sapiens)
        
        PLK2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NYY3 PLK2

Gene Names

PLK2, SNK

Chain

chain:1-685

Reference Genes

BioGPS Gene:10769 PLK2

COSMIC (genes):PLK2 PLK2

CTD Gene:10769 PLK2

dbSNP Gene:10769 PLK2

ENSEMBL:ENSG00000145632 PLK2

ENSEMBL_homo_sapiens_GENE:ENSG00000145632.15 PLK2

HGNC:19699 PLK2

KEGG Gene (Homo sapiens):10769 PLK2

Monarch:10769 PLK2

NCBI Gene:10769 PLK2

OMIM:607023 PLK2

UCSC:Q9NYY3 PLK2

Reference Transcript

Other Identifiers

10769

11722162_a_at

11722163_x_at

11746837_a_at

11755161_s_at

16996433

201939_PM_at

201939_at

2858022

2858024

2858025

2858026

2858028

2858030

2858031

2858032

2858034

2858036

2858037

2858038

2858040

2858042

2858044

2858046

2858048

2858050

2858052

2858053

41544_at

8112202

A_23_P30254

GE54551

GO:0000082

GO:0000166

GO:0000278

GO:0000776

GO:0000785

GO:0000922

GO:0002376

GO:0002862

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005694

GO:0005737

GO:0005813

GO:0005814

GO:0005815

GO:0005829

GO:0005856

GO:0006468

GO:0006914

GO:0006954

GO:0006977

GO:0007010

GO:0007052

GO:0007265

GO:0007613

GO:0010508

GO:0012501

GO:0016301

GO:0016310

GO:0016525

GO:0016740

GO:0018105

GO:0023052

GO:0030163

GO:0030425

GO:0032486

GO:0036211

GO:0042995

GO:0043008

GO:0043066

GO:0043123

GO:0043226

GO:0045732

GO:0046599

GO:0048167

GO:0048856

GO:0048870

GO:0050877

GO:0060291

GO:0060292

GO:0071866

GO:0090050

GO:0106310

GO:0140096

GO:2000773

HMNXSV003048616

ILMN_1717706

PH_hs_0024593

TC05001385.hg

g5730054_3p_at

Participates

as a member of

PLK2, MAPK14 [cytosol] (Homo sapiens)

as an output of

Inferred To

PLK2 [cytosol] (Bos taurus)

PLK2 [cytosol] (Canis familiaris)

PLK2 [cytosol] (Danio rerio)

PLK2 [cytosol] (Gallus gallus)

PLK2 [cytosol] (Mus musculus)

PLK2 [cytosol] (Rattus norvegicus)

PLK2 [cytosol] (Sus scrofa)

PLK2 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001239155.1, NP_006613.2

ZINC - World Drugs

PLK2_HUMAN

Guide to Pharmacology - Targets

2169

OpenTargets

ENSG00000145632

ZINC - FDA approved

PLK2_HUMAN

ZINC - Substances

PLK2_HUMAN

ZINC - Biogenic

PLK2_HUMAN

ZINC target

Q9NYY3

PRO

Q9NYY3

PDB

4I6F, 4I5P, 4I6B, 4I6H, 4RS6, 4I5M, 4XB0

ZINC - Investigational

PLK2_HUMAN

GeneCards

Q9NYY3

HPA

ENSG00000145632-PLK2

Ensembl

ENSG00000145632, ENST00000274289, ENSP00000274289

Pharos - Targets

Q9NYY3

ZINC - Predictions - Purchasable

PLK2_HUMAN

HMDB Protein

HMDBP01434

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q86Y33 CD20B			0.556	3