STEAP3 binds BNIP3L

Stable Identifier
R-HSA-6801195
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

STEAP3 (TSAP6) forms a complex with a pro-apoptotic protein BNIP3L (NIX) and cooperates with BNIP3L in promoting apoptosis, but the exact mechanism is not known (Passer et al. 2003).

While STEAP3 localizes to endosome membranes, BNIP3L localizes to the outer mitochondrial membrane. BNIP3L has recently been implicated in the relocalization of endo-lysosomes to inner mitochondrial compartments, which can play a role in endo-lysosomal processing of mitochondria (Hamacher-Brady et al. 2014).

Literature References
PubMed ID Title Journal Year
12606722 The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase

Passer, BJ, Nancy-Portebois, V, Amzallag, N, Prieur, S, Cans, C, Roborel de Climens, A, Fiucci, G, Bouvard, V, Tuynder, M, Susini, L, Morchoisne, S, Crible, V, Lespagnol, A, Dausset, J, Oren, M, Amson, R, Telerman, A

Proc. Natl. Acad. Sci. U.S.A. 2003
25080938 Intramitochondrial recruitment of endolysosomes mediates Smac degradation and constitutes a novel intrinsic apoptosis antagonizing function of XIAP E3 ligase

Hamacher-Brady, A, Choe, SC, Krijnse-Locker, J, Brady, NR

Cell Death Differ. 2014
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created