The PIDDosome binds CASP2

Stable Identifier
R-HSA-6800798
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PIDD1, when phosphorylated by ATM at threonine residue T788, associates with CRADD (RAIDD), forming a multisubunit structure known as the PIDDosome (Tinel and Tschopp 2004, Ando et al. 2012). The PIDDosome binds procaspase-2 (CASP2), with CASP2 directly interacting with the CRADD subunit (Tinel and Tschopp 2004).

Literature References
PubMed ID Title Journal Year
22854598 PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling

Ando, K, Kernan, JL, Liu, PH, Sanda, T, Logette, E, Tschopp, J, Look, AT, Wang, J, Bouchier-Hayes, L, Sidi, S

Mol. Cell 2012
15073321 The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress

Tinel, A, Tschopp, J

Science 2004
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created