Reactome | TP53 binds PPP1R13L

TP53 binds PPP1R13L

Stable Identifier

R-HSA-6799761

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Association with Co-factors (Homo sapiens)
        
        TP53 binds PPP1R13L (Homo sapiens)

General

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PPP1R13L encodes the inhibitory member of the ASPP family - iASPP. PPP1R13L binds TP53 (p53) and inhibits its pro-apoptotic transcriptional activity. PPP1R13L cooperates with RAS, adenovirus protein E1A and the human papillomavirus protein E7 in cell transformation (Bergamaschi et al. 2003, Wilson et al. 2014). The C-terminus of PPP1R13L consists of four ankyrin repeats and an SH3 domain that form a p53-binding site. PPP1R13L binds the DNA binding site of TP53 (Robinson et al. 2008). PPP1R13L also interacts with p53 family members TP63 (p63) and TP73 (p73) (Robinson et al. 2008) and inhibits their pro-apoptotic transcriptional activity (Cai et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
12524540	iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human Kuwabara, PE, Hsieh, JK, Samuels, Y, Zhong, S, Trigiante, G, Lu, X, Campargue, I, O'Connor, DJ, Bergamaschi, D, Tomlinson, ML, O'Neil, NJ, Crook, T	Nat. Genet.	2003
24714389	Inhibitor of apoptosis-stimulating protein of p53 (iASPP) is required for neuronal survival after axonal injury Wilson, AM, Hauswirth, WW, Boye, SL, Chiodo, VA, Di Polo, A, Brecha, NC	PLoS ONE	2014
22538442	iASPP inhibits p53-independent apoptosis by inhibiting transcriptional activity of p63/p73 on promoters of proapoptotic genes Qiu, S, Liu, ZJ, Gu, SZ, Gao, X, Cai, Y	Apoptosis	2012
18275817	Biochemical and structural studies of ASPP proteins reveal differential binding to p53, p63, and p73 Lu, X, Robinson, RA, Jones, EY, Siebold, C	Structure	2008