Reactome | RPS18 [nucleoplasm]

RPS18 [nucleoplasm]

Stable Identifier

R-HSA-6798701

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

40S small ribosomal protein 18, P25232, 40S ribosomal protein S18, KE-3, KE3

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P62269 RPS18

Gene Names

RPS18, D6S218E

Chain

initiator methionine:, chain:2-152

Reference Genes

BioGPS Gene:6222 RPS18

COSMIC (genes):RPS18 RPS18

CTD Gene:6222 RPS18

dbSNP Gene:6222 RPS18

ENSEMBL:ENSG00000231500 RPS18

ENSEMBL_homo_sapiens_GENE:ENSG00000096150.9 RPS18

ENSEMBL_homo_sapiens_GENE:ENSG00000223367.6 RPS18

ENSEMBL_homo_sapiens_GENE:ENSG00000226225.6 RPS18

ENSEMBL_homo_sapiens_GENE:ENSG00000231500.7 RPS18

ENSEMBL_homo_sapiens_GENE:ENSG00000235650.6 RPS18

HGNC:10401 RPS18

KEGG Gene (Homo sapiens):6222 RPS18

Monarch:6222 RPS18

NCBI Gene:6222 RPS18

OMIM:180473 RPS18

UCSC:P62269 RPS18

Reference Transcript

RefSeq:NM_022551.2 RPS18

Other Identifiers

11756437_x_at

17041345

201049_PM_s_at

201049_s_at

2686718

2686719

2686720

2686721

2686724

2903558

2903562

2903567

2903569

2903571

2903573

2930816

31545_at

3548492

3746486

6222

8118644

8178253

8179544

A_14_P121071

A_23_P214666

GE508175

GO:0002181

GO:0003676

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005840

GO:0005925

GO:0006412

GO:0014069

GO:0015935

GO:0016020

GO:0019843

GO:0022626

GO:0022627

GO:0043226

GO:0045202

GO:0070062

GO:1990904

HMNXSV003042648

ILMN_1753534

PH_hs_0029574

TC06000417.hg

TC06002737.hg

TC6_cox_hap2000107.hg

TC6_dbb_hap3000099.hg

TC6_mcf_hap5000092.hg

TC6_qbl_hap6000098.hg

TC6_ssto_hap7000088.hg

X69150_at

g11968181_3p_a_at

Participates

as a component of

18SE pre-40S particle [nucleoplasm] (Homo sapiens)

Other forms of this molecule

RPS18 [cytosol]

Inferred To

Ghost homologue of RPS18 [nucleoplasm] (Gallus gallus)

RPS18A [nucleoplasm] (Saccharomyces cerevisiae)

RPS18 [nucleoplasm] (Bos taurus)

RPS18 [nucleoplasm] (Canis familiaris)

RPS18 [nucleoplasm] (Plasmodium falciparum)

RPS18 [nucleoplasm] (Sus scrofa)

rps1802 [nucleoplasm] (Schizosaccharomyces pombe)

rps-18 [nucleoplasm] (Caenorhabditis elegans)

RpS18 [nucleoplasm] (Drosophila melanogaster)

Homologues of RPS18 [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of RPS18 [nucleoplasm] (Schizosaccharomyces pombe)

rps1801 [nucleoplasm] (Schizosaccharomyces pombe)

Rps18 [nucleoplasm] (Mus musculus)

Rps18 [nucleoplasm] (Rattus norvegicus)

RPS18B [nucleoplasm] (Saccharomyces cerevisiae)

rps18 [nucleoplasm] (Danio rerio)

rps18 [nucleoplasm] (Dictyostelium discoideum)

rps18 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_072045.1

OpenTargets

ENSG00000231500

HPA

ENSG00000231500-RPS18

GeneCards

P62269

Ensembl

ENST00000439602, ENSP00000211372, ENSG00000235650, ENST00000211372, ENSG00000226225, ENSG00000231500, ENST00000454021, ENSG00000223367, ENST00000434122, ENST00000457341, ENSP00000416110, ENSP00000393241, ENSP00000403175, ENSP00000412583, ENSG00000096150

PRO

P62269

Pharos - Targets

P62269

PDB

6FEC, 5AJ0, 7QP6, 7WTV, 8G5Y, 6OLI, 6IP6, 6ZXD, 8T4S, 7QP7, 6ZVJ, 6Y0G, 6G18, 6YBS, 6G4S, 6Y2L, 7K5I, 7A09, 6ZOL, 5A2Q, 6OM0, 6ZMT, 6ZXF, 7WTZ, 6ZLW, 6Y57, 6Z6M, 6ZM7, 6ZXG, 6Z6N, 6ZP4, 8G6J, 6ZUO, 6OLF, 6ZXH, 5T2C, 7XNX, 6XA1, 6G5H, 6IP5, 8G60, 7WTT, 7WTU, 8G61, 6IP8, 6G5I, 6ZMO, 7R4X, 7WTW, 6ZVH, 7WTX, 6G4W, 7WU0, 6ZOJ, 5FLX, 7TQL, 5VYC, 6ZMW, 6OLZ, 6G51, 6QZP, 6ZXE, 6ZN5, 4V6X, 6OM7, 6ZON, 6Z6L, 8GLP, 6G53, 5LKS, 6OLE, 6ZME, 7XNY, 6ZV6, 6OLG, 4UG0, 5OA3, 6ZMI

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.607	3
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.59	3
UniProt:Q99558 MAP3K14	5	p-T559-MAP3K14 [cytosol] (R-HSA-5668531) K48polyUb-NIK [cytosol] (R-HSA-5668525) Active NIK [cytosol] (R-HSA-5607646) MAP3K14 [cytosol] (R-HSA-168189) p-MAP3K14 [cytosol] (R-HSA-168187)	0.564	2
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.527	2
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	6
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	12

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