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NTRK3 [plasma membrane]
Stable Identifier
R-HSA-6798240
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
TrKC, NT-3 growth factor receptor, NTRK3_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Neuronal System (Homo sapiens)
Protein-protein interactions at synapses (Homo sapiens)
Receptor-type tyrosine-protein phosphatases (Homo sapiens)
PTPRS binds NTRK3 (Homo sapiens)
NTRK3 [plasma membrane] (Homo sapiens)
PTPRS:NTRK3 [plasma membrane] (Homo sapiens)
NTRK3 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK3 (TRKC) (Homo sapiens)
NTF3 activates NTRK3 signaling (Homo sapiens)
NTF3 binds NTRK3 (Homo sapiens)
NTF3:NTRK3 homodimer [plasma membrane] (Homo sapiens)
NTRK3 [plasma membrane] (Homo sapiens)
NTRK3 [plasma membrane] (Homo sapiens)
NTRK3 dimers trans-autophosphorylate (Homo sapiens)
NTF3:NTRK3 homodimer [plasma membrane] (Homo sapiens)
NTRK3 [plasma membrane] (Homo sapiens)
NTRK3 as a dependence receptor (Homo sapiens)
Unknown caspase cleaves NTRK3 (Homo sapiens)
NTRK3 [plasma membrane] (Homo sapiens)
Protein tyrosine phosphatases dephosphorylate NTRK3 (Homo sapiens)
NTF3:NTRK3 homodimer [plasma membrane] (Homo sapiens)
NTRK3 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q16288 NTRK3
Gene Names
NTRK3, TRKC
Chain
signal peptide:1-31, chain:32-839
Reference Genes
BioGPS Gene:4916 NTRK3
COSMIC (genes):NTRK3 NTRK3
CTD Gene:4916 NTRK3
dbSNP Gene:4916 NTRK3
ENSEMBL:ENSG00000140538 NTRK3
ENSEMBL_homo_sapiens_GENE:ENSG00000140538.17 NTRK3
HGNC:8033 NTRK3
KEGG Gene (Homo sapiens):4916 NTRK3
Monarch:4916 NTRK3
NCBI Gene:4916 NTRK3
OMIM:191316 NTRK3
UCSC:Q16288 NTRK3
Reference Transcript
RefSeq:NM_001012338.2 NTRK3
RefSeq:NM_001320135.1 NTRK3
RefSeq:XM_017022253.1 NTRK3
RefSeq:NM_001320134.1 NTRK3
RefSeq:NM_002530.3 NTRK3
Other Identifiers
1059_at
1060_g_at
11727684_at
11727685_at
11740579_a_at
11752325_a_at
1557795_PM_s_at
1557795_s_at
206462_PM_s_at
206462_s_at
213960_PM_at
213960_at
215025_PM_at
215025_at
215115_PM_x_at
215115_x_at
215311_PM_at
215311_at
217033_PM_x_at
217033_x_at
217377_PM_x_at
217377_x_at
228849_PM_at
228849_at
32345_at
3637794
3637795
3637796
3637797
3637799
3637801
3637802
3637803
3637805
3637807
3637809
3637810
3637811
3637812
3637813
3637815
3637817
3637819
3637820
3637821
3637822
3637823
3637824
3637825
3637826
3637838
3637841
3637845
3637872
3637873
3637874
3637875
3637876
3637877
3637878
3637879
3637900
3637921
3637922
3637927
3637928
3637929
3637930
3637931
3637936
3637945
3637949
3637978
3637979
3637980
3637981
3637982
3637986
3637987
3637988
3637989
37839_at
39596_at
4916
7991186
80936_at
A_23_P205900
A_23_P88538
A_24_P810476
A_32_P141969
A_33_P3260134
A_33_P3322814
GE481796
GE58876
GO:0000166
GO:0001933
GO:0001934
GO:0002039
GO:0003824
GO:0004672
GO:0004713
GO:0004714
GO:0005030
GO:0005515
GO:0005524
GO:0005886
GO:0006468
GO:0007165
GO:0007169
GO:0007399
GO:0007507
GO:0008284
GO:0010628
GO:0010976
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0023052
GO:0030154
GO:0030335
GO:0030424
GO:0032148
GO:0033138
GO:0036211
GO:0038179
GO:0043121
GO:0043235
GO:0043406
GO:0048856
GO:0048870
GO:0050927
GO:0051896
GO:0051897
GO:0060089
GO:0090630
GO:0140096
GO:1990090
HMNXSV003005264
HMNXSV003005684
HMNXSV003043601
HMNXSV003049040
HMNXSV003052405
Hs.113137.0.A1_3p_at
Hs.13223.0.S1_3p_at
Hs.169081.1.A1_3p_s_at
Hs.185701.0.S1_3p_at
Hs.26776.1.S1_3p_at
Hs2.436210.1.S1_3p_s_at
ILMN_1687967
ILMN_1734893
ILMN_1837429
ILMN_1872446
PH_hs_0002366
PH_hs_0021606
PH_hs_0038721
S76475_at
TC15001815.hg
TC15002689.hg
TC15002690.hg
U05012_s_at
p25943
Participates
as a component of
PTPRS:NTRK3 [plasma membrane] (Homo sapiens)
NTF3:NTRK3 homodimer [plasma membrane] (Homo sapiens)
as an input of
PTPRS binds NTRK3 (Homo sapiens)
NTF3 binds NTRK3 (Homo sapiens)
Unknown caspase cleaves NTRK3 (Homo sapiens)
Other forms of this molecule
NTRK3(32-495) [plasma membrane]
NTRK3(642-839) [cytosol]
NTRK3(496-641) [mitochondrial outer membrane]
NTRK3(496-641) [cytosol]
p-5Y-NTRK3 [plasma membrane]
Inferred To
NTRK3 [plasma membrane]
(Bos taurus)
NTRK3 [plasma membrane]
(Canis familiaris)
NTRK3 [plasma membrane]
(Gallus gallus)
NTRK3 [plasma membrane]
(Mus musculus)
NTRK3 [plasma membrane]
(Rattus norvegicus)
NTRK3 [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
XP_016877742.1
,
NP_001307063.1
,
NP_001012338.1
,
NP_001307064.1
,
NP_002521.2
ZINC - World Drugs
NTRK3_HUMAN
Guide to Pharmacology - Targets
1819
OpenTargets
ENSG00000140538
ZINC - FDA approved
NTRK3_HUMAN
ZINC - Substances
NTRK3_HUMAN
ZINC target
Q16288
ZINC - Biogenic
NTRK3_HUMAN
PRO
Q16288
PDB
3V5Q
,
1WWC
,
6KZC
,
4YMJ
,
6KZD
ZINC - Investigational
NTRK3_HUMAN
IntEnz
2.7.10.1
GeneCards
Q16288
HPA
ENSG00000140538-NTRK3
Ensembl
ENST00000557856
,
ENSP00000318328
,
ENST00000357724
,
ENSP00000485864
,
ENST00000317501
,
ENSP00000511942
,
ENST00000629765
,
ENST00000394480
,
ENSP00000377990
,
ENSP00000350356
,
ENSP00000453959
,
ENST00000695462
,
ENSG00000140538
Pharos - Targets
Q16288
Orphanet
19504
ZINC - Predictions - Purchasable
NTRK3_HUMAN
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P18031 PTPN1
2
PTPN1 [cytosol]
(R-HSA-210625)
PTPN1 [endosome membrane]
(R-HSA-9815895)
0.571
2
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.564
2
UniProt:Q6PKX4 DOK6
1
DOK6 [cytosol]
(R-HSA-8855620)
0.548
3
UniProt:Q99523 SORT1
2
SORT1 [cytoplasmic vesicle membrane]
(R-HSA-434221)
SORT1 [Golgi membrane]
(R-HSA-434332)
0.544
2
UniProt:Q16620 NTRK2
6
p-Y706,Y707-NTRK2 [plasma membrane]
(R-HSA-9037044)
p-5Y,S479-NTRK2 [plasma membrane]
(R-HSA-9032864)
NTRK2 [plasma membrane]
(R-HSA-6798236)
p-5Y-NTRK2 [plasma membrane]
(R-HSA-9026475)
p-5Y-NTRK2 [Golgi membrane]
(R-HSA-3008809)
NTRK2 [Golgi membrane]
(R-HSA-3008801)
0.539
3
UniProt:P04439 HLA-A
9
K48polyUb-HLA-A A-2 [endoplasmic reticulum membrane]
(R-HSA-8943073)
HLA-A A-3 [endoplasmic reticulum membrane]
(R-HSA-8943090)
HLA class I histocompatibility antigen, A-3 alpha chain precursor [early endosome membrane]
(R-HSA-1236826)
HLA class I histocompatibility antigen, A-3 alpha chain precursor [phagocytic vesicle membrane]
(R-HSA-1236740)
HLA class I histocompatibility antigen, A-3 alpha chain precursor [recycling endosome membrane]
(R-HSA-8863889)
HLA class I histocompatibility antigen, A-3 alpha chain precursor [plasma membrane]
(R-HSA-197642)
HLA class I histocompatibility antigen, A-3 alpha chain precursor [Golgi membrane]
(R-HSA-983376)
HLA class I histocompatibility antigen, A-3 alpha chain precursor [ER to Golgi transport vesicle membrane]
(R-HSA-983347)
HLA class I histocompatibility antigen, A-3 alpha chain precursor [integral component of lumenal side of endoplasmic reticulum membrane]
(R-HSA-983100)
0.527
2
UniProt:P40939 HADHA
1
HADHA [mitochondrial inner membrane]
(R-HSA-77264)
0.527
2
UniProt:P27824 CANX
2
CANX [integral component of lumenal side of endoplasmic reticulum membrane]
(R-HSA-983091)
CANX [endoplasmic reticulum lumen]
(R-HSA-195906)
0.527
2
UniProt:Q15375 EPHA7
2
EPHA7 [plasma membrane]
(R-HSA-2682337)
p-Y608,Y614-EPHA7 [plasma membrane]
(R-HSA-3928358)
0.499
2
UniProt:P04629 NTRK1
4
p-5Y-NTRK1 [Golgi membrane]
(R-HSA-3008810)
NTRK1 [Golgi membrane]
(R-HSA-3008805)
NTRK1 [plasma membrane]
(R-HSA-3008784)
p-5Y-NTRK1 [plasma membrane]
(R-HSA-3009413)
0.499
2
UniProt:Q16832 DDR2
1
DDR2 [plasma membrane]
(R-HSA-211419)
0.499
2
UniProt:P61619 SEC61A1
2
SEC61A1 [endoplasmic reticulum membrane]
(R-HSA-444591)
SEC61A1 [phagocytic vesicle membrane]
(R-HSA-1236813)
0.499
2
UniProt:Q9UBV2 SEL1L
1
SEL1L [endoplasmic reticulum membrane]
(R-HSA-1911545)
0.499
2
UniProt:P08581 MET
7
MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane]
(R-HSA-8875181)
MonoUb-K,p-Y1003,4Y-MET [plasma membrane]
(R-HSA-8875180)
p-Y1003,4Y-MET [plasma membrane]
(R-HSA-8874689)
p-Y1349,Y1356-MET [plasma membrane]
(R-HSA-6807032)
p-Y1234,Y1235,Y1356-MET [plasma membrane]
(R-HSA-6807014)
MET [plasma membrane]
(R-HSA-419603)
p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane]
(R-HSA-6806973)
0.499
2
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