Reactome | BTG2 binds CCR4-NOT complex

BTG2 binds CCR4-NOT complex

Stable Identifier

R-HSA-6798044

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
        
        TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Homo sapiens)
        
        BTG2 binds CCR4-NOT complex (Homo sapiens)

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BTG2, through its conserved BTG domain, binds catalytic subunits CNOT7 and CNOT8 of the CCR4-NOT complex and promotes mRNA deadenylation activity of the CCR4-NOT (Rouault et al. 1998, Mauxion et al. 2008, Doidge et al. 2012). The interaction with the CCR4-NOT is needed for the antiproliferative activity of BTG2 (Horiuchi et al. 2009, Doidge et al. 2012, Ezzeddine et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
18337750	The BTG2 protein is a general activator of mRNA deadenylation Mauxion, F, Faux, C, Séraphin, B	EMBO J.	2008
19276069	Structural basis for the antiproliferative activity of the Tob-hCaf1 complex Horiuchi, M, Takeuchi, K, Noda, N, Muroya, N, Suzuki, T, Nakamura, T, Kawamura-Tsuzuku, J, Takahasi, K, Yamamoto, T, Inagaki, F	J. Biol. Chem.	2009
9712883	Interaction of BTG1 and p53-regulated BTG2 gene products with mCaf1, the murine homolog of a component of the yeast CCR4 transcriptional regulatory complex Rouault, JP, Prévôt, D, Berthet, C, Birot, AM, Billaud, M, Magaud, JP, Corbo, L	J. Biol. Chem.	1998
23236473	The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex Doidge, R, Mittal, S, Aslam, A, Winkler, GS	PLoS ONE	2012
22252318	Evidence providing new insights into TOB-promoted deadenylation and supporting a link between TOB's deadenylation-enhancing and antiproliferative activities Ezzeddine, N, Chen, CY, Shyu, AB	Mol. Cell. Biol.	2012