TP53 stimulates BNIP3L expression

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R-HSA-6798004
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Reaction [omitted]
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Homo sapiens
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TP53 (p53) and CREBBP (CBP) bound to the BNIP3L gene stimulate expression of the BNIP3L. BNIP3L is an outer mitochondrial membrane protein that belongs to the BCL2 family and promotes apoptosis of cells under hypoxic stress (Fei et al. 2004).

Literature References
PubMed ID Title Journal Year
15607964 Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth

Fei, P, Wang, W, Kim, SH, Wang, S, Burns, TF, Sax, JK, Buzzai, M, Dicker, DT, McKenna, WG, Bernhard, EJ, El-Deiry, WS

Cancer Cell 2004
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