Expression of IL13-upregulated plasma membrane proteins

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R-HSA-6788346
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Reaction [omitted]
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Homo sapiens
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In monocytes and macrophages Interleukin-13 (IL13) enhances the expression of many members of the integrin family including Integrin alpha M (ITGAM, CD11b), Integrin alpha-X (ITGAX, CD11c), Integrin beta 2 (ITGB2, CD18) and Integrin beta 1 (ITGB1, CD29) (Zurawski & de Vries 1994), MHC class II and ow affinity immunoglobulin epsilon Fc receptor (FCER2, CD23) expression (de Vries 1998). In endothelial cells IL13 induces expression of Vascular cell adhesion protein 1 (VCAM1), which is important in the recruitment of eosinophils (Bochner et al. 1995).

Literature References
PubMed ID Title Journal Year
7907877 Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells

Zurawski, G, de Vries, JE

Immunol. Today 1994
9723655 The role of IL-13 and its receptor in allergy and inflammatory responses

de Vries, JE

J. Allergy Clin. Immunol. 1998
7529288 IL-13 selectively induces vascular cell adhesion molecule-1 expression in human endothelial cells

Bochner, BS, Klunk, DA, Sterbinsky, SA, Coffman, RL, Schleimer, RP

J. Immunol. 1995
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