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FLT3 [plasma membrane]
Stable Identifier
R-HSA-6786756
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
STK-1
Icon
Locations in the PathwayBrowser for interactor UniProt:Q13322 GRB10
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
FLT3 Signaling (Homo sapiens)
FLT3LG dimer binds FLT3 (Homo sapiens)
FLT3 [plasma membrane] (Homo sapiens)
FLT3LG dimer:FLT3 binds FLT3 (Homo sapiens)
FLT3 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P36888 FLT3
Gene Names
FLT3, CD135, FLK2, STK1
Chain
signal peptide:1-26, chain:27-993
Reference Genes
BioGPS Gene:2322 FLT3
COSMIC (genes):FLT3 FLT3
CTD Gene:2322 FLT3
dbSNP Gene:2322 FLT3
ENSEMBL:ENSG00000122025 FLT3
HGNC:3765 FLT3
KEGG Gene (Homo sapiens):2322 FLT3
Monarch:2322 FLT3
NCBI Gene:2322 FLT3
OMIM:136351 FLT3
UCSC:P36888 FLT3
Reference Transcript
RefSeq:NM_004119.2 FLT3
Other Identifiers
0006290286
1065_at
11737027_a_at
16777685
1RJB
206674_at
2322
34583_at
3507201
3507202
3507205
3507206
3507207
3507210
3507211
3507212
3507213
3507216
3507217
3507218
3507219
3507221
3507222
3507223
3507224
3507225
3507226
3507228
3507229
3507230
3507231
3507233
3507234
3507237
3507239
3507242
3507243
3507244
3QS7
3QS9
47539
4RT7
4XUF
5X02
6IL3
7970737
AAA18947
AAA35487
AAI26351
AAI44040
AAI44041
AL356915
AL445262
AL591024
BC126350
BC144039
BC144040
CAA81393
CCDS31953
CH471075
E7ER61
EAX08424
ENSG00000122025
ENSP00000241453
ENSP00000370374
ENST00000241453
ENST00000241453.11
ENST00000380987
EntrezGene:2322
EntrezGene:FLT3
FLT3
FLT3-201
g4758395_3p_at
GE58857
GO:0000165
GO:0000166
GO:0001776
GO:0002244
GO:0002318
GO:0002328
GO:0002376
GO:0002521
GO:0003674
GO:0004672
GO:0004713
GO:0004714
GO:0004896
GO:0005021
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005737
GO:0005783
GO:0005788
GO:0005829
GO:0005886
GO:0005887
GO:0006464
GO:0006468
GO:0006629
GO:0007165
GO:0007169
GO:0008134
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0010243
GO:0014068
GO:0016020
GO:0016021
GO:0016032
GO:0016301
GO:0016310
GO:0016740
GO:0018108
GO:0019221
GO:0030097
GO:0030098
GO:0030154
GO:0030183
GO:0031100
GO:0032991
GO:0035259
GO:0035726
GO:0038084
GO:0042531
GO:0042592
GO:0042803
GO:0042981
GO:0043167
GO:0043226
GO:0043235
GO:0043406
GO:0043410
GO:0043552
GO:0043621
GO:0044403
GO:0044877
GO:0046651
GO:0046777
GO:0048856
GO:0071345
GO:0071385
GO:0097028
HGNC:3765
HPA047539
ILMN_1766363
IPR000719
IPR001245
IPR001824
IPR007110
IPR008266
IPR011009
IPR013151
IPR013783
IPR017441
IPR020635
IPR030118
IPR036179
L36162
LRG_457
LRG_457t1
MIM:136351
MIM:601626
MIM:613065
NM_004119
NP_004110
PF00047
PF07714
PH_hs_0000046
SM00219
TC13000515.hg
TC13001385.hg
U02687
U02687_at
UPI00001FC90B
XM_011535015
XM_011535017
XM_011535018
XM_017020486
XM_017020487
XM_017020488
XM_017020489
XP_011533317
XP_011533319
XP_011533320
XP_016875975
XP_016875976
XP_016875977
XP_016875978
Z26652
Participant Of
input
FLT3LG dimer binds FLT3
FLT3LG dimer:FLT3 binds FLT3
hasComponent
FLT3LG dimer:FLT3 [plasma membrane]
FLT3LG dimer:FLT3 dimer [plasma membrane]
Other forms of this molecule
Autophosphorylated FLT3 [plasma membrane]
Inferred To
Homologues of FLT3 [plasma membrane] (Caenorhabditis elegans)
Homologues of FLT3 [plasma membrane] (Drosophila melanogaster)
FLT3 [plasma membrane] (Bos taurus)
FLT3 [plasma membrane] (Caenorhabditis elegans)
FLT3 [plasma membrane] (Canis familiaris)
FLT3 [plasma membrane] (Danio rerio)
FLT3 [plasma membrane] (Drosophila melanogaster)
FLT3 [plasma membrane] (Gallus gallus)
FLT3 [plasma membrane] (Mus musculus)
FLT3 [plasma membrane] (Rattus norvegicus)
FLT3 [plasma membrane] (Sus scrofa)
FLT3 [plasma membrane] (Xenopus tropicalis)
Cross References
RefSeq
NP_004110.2
ZINC - World Drugs
FLT3_HUMAN
OpenTargets
ENSG00000122025
ZINC - FDA approved
FLT3_HUMAN
ZINC - Substances
FLT3_HUMAN
ZINC - Biogenic
FLT3_HUMAN
ZINC target
P36888
PRO
P36888
PDB
6IL3
,
4RT7
,
1RJB
,
3QS7
,
3QS9
,
5X02
,
4XUF
ZINC - Investigational
FLT3_HUMAN
ZINC - Metabolites
FLT3_HUMAN
IntEnz
2.7.10.1
GeneCards
P36888
Orphanet
16784
ZINC - Predictions - Purchasable
FLT3_HUMAN
HMDB Protein
HMDBP01189
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P43405 SYK
6
SYK [plasma membrane]
(R-HSA-139844)
p-Y-SYK [plasma membrane]
(R-HSA-429432)
p-6Y-SYK [cytosol]
(R-HSA-983586)
p-6Y-SYK [cytosol]
(R-HSA-1861712)
p-Y348-SYK [cytosol]
(R-HSA-437953)
SYK [cytosol]
(R-HSA-58268)
0.737
22
UniProt:Q13322 GRB10
1
GRB10 [cytosol]
(R-HSA-110009)
0.591
6
UniProt:P42684 ABL2
1
ABL2 [cytosol]
(R-HSA-375998)
0.544
3
UniProt:Q8R4L0 SLAP2
0.524
14
UniProt:Q06124 PTPN11
4
PTPN11 [nucleoplasm]
(R-HSA-8937745)
p-Y546-PTPN11 [cytosol]
(R-HSA-1369081)
p-Y546,Y584-PTPN11 [cytosol]
(R-HSA-162573)
PTPN11 [cytosol]
(R-HSA-162563)
0.462
2
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