Reactome | p-Y-IL13RA1 [plasma membrane]

p-Y-IL13RA1 [plasma membrane]

Stable Identifier

R-HSA-6786750

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Interleukin-13 receptor alpha-1, I13R1_HUMAN

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Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
      - IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated (Homo sapiens)
        
        IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL13RA1 [plasma membrane] (Homo sapiens)
      - STAT1,STAT3,STAT6 bind IL13:IL13R type II (Homo sapiens)
        
        IL13-bound tyrosine-phosphorylated IL13 receptor type II with STAT1,STAT3,STAT6 [plasma membrane] (Homo sapiens)
        
        IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL13RA1 [plasma membrane] (Homo sapiens)
        
        IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL13RA1 [plasma membrane] (Homo sapiens)
      - STAT1,STAT3,STAT6 phosphorylation (Homo sapiens)
        
        IL13-bound tyrosine-phosphorylated IL13 receptor type II with STAT1,STAT3,STAT6 [plasma membrane] (Homo sapiens)
        
        IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL13RA1 [plasma membrane] (Homo sapiens)
        
        IL13-bound tyrosine-phosphorylated IL13 receptor type II with phosphorylated STAT1,STAT3,STAT6 [plasma membrane] (Homo sapiens)
        
        IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL13RA1 [plasma membrane] (Homo sapiens)
      - p-Y-STATs dissociate (Homo sapiens)
        
        IL13-bound tyrosine-phosphorylated IL13 receptor type II with phosphorylated STAT1,STAT3,STAT6 [plasma membrane] (Homo sapiens)
        
        IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL13RA1 [plasma membrane] (Homo sapiens)
        
        IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL13RA1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P78552 IL13RA1

Gene Names

IL13RA1, IL13R, IL13RA

Chain

signal peptide:1-21, chain:22-427

Reference Genes

BioGPS Gene:3597 IL13RA1

COSMIC (genes):IL13RA1 IL13RA1

CTD Gene:3597 IL13RA1

dbSNP Gene:3597 IL13RA1

ENSEMBL:ENSG00000131724 IL13RA1

ENSEMBL_homo_sapiens_GENE:ENSG00000131724.11 IL13RA1

HGNC:5974 IL13RA1

KEGG Gene (Homo sapiens):3597 IL13RA1

Monarch:3597 IL13RA1

NCBI Gene:3597 IL13RA1

OMIM:300119 IL13RA1

UCSC:P78552 IL13RA1

Reference Transcript

RefSeq:NM_001560.2 IL13RA1

Other Identifiers

11727903_a_at

11727904_s_at

11727905_a_at

11750299_a_at

17106493

201887_PM_at

201887_at

201888_PM_s_at

201888_s_at

210904_PM_s_at

210904_s_at

211612_PM_s_at

211612_s_at

35797_at

3597

359_at

3988547

3988548

3988550

3988552

3988554

3988556

3988558

3988559

3988562

3988563

3988577

3988578

3988580

3988581

3988582

3988583

3988584

3988585

3988586

3988587

8169580

A_14_P106150

A_23_P137196

A_24_P280113

GE87827

GO:0004896

GO:0005515

GO:0005886

GO:0005898

GO:0007166

GO:0008284

GO:0009897

GO:0016020

GO:0019221

GO:0019955

GO:0023052

GO:0043235

GO:0060089

HMNXSV003038489

ILMN_1768505

PH_hs_0014765

TC0X000575.hg

Y10659_at

g1695875_3p_s_at

g4504646_3p_at

g5174767_3p_at

g5870850_3p_a_at

Participates

as a component of

p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)

Other forms of this molecule

IL13RA1 [plasma membrane]

Inferred To

phospho-Il13ra1 [plasma membrane] (Mus musculus)

phospho-Il13ra1 [plasma membrane] (Rattus norvegicus)

phospho-IL13RA1 [plasma membrane] (Bos taurus)

phospho-IL13RA1 [plasma membrane] (Canis familiaris)

phospho-IL13RA1 [plasma membrane] (Sus scrofa)

phospho-p-Y-IL13RA1 [plasma membrane] (Gallus gallus)

Modified Residues

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001551.1

Guide to Pharmacology - Targets

1700

OpenTargets

ENSG00000131724

HPA

ENSG00000131724-IL13RA1

GeneCards

P78552

Ensembl

ENST00000371642, ENSP00000360730, ENSG00000131724, ENSP00000360705, ENST00000371666

PRO

P78552

Pharos - Targets

P78552

Orphanet

29641

PDB

5E4E, 3BPN, 4HWB, 3BPO

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35225 IL13	1	IL13 [extracellular region] (R-HSA-447211)	0.74	6
UniProt:P05112 IL4	1	IL4 [extracellular region] (R-HSA-447110)	0.611	3
UniProt:P24394 IL4R	2	IL4R [plasma membrane] (R-HSA-449670) p-Y-IL4R [plasma membrane] (R-HSA-6786087)	0.558	4
UniProt:Q8TDR0 TRAF3IP1	2	TRAF3IP1 [ciliary tip] (R-HSA-5625404) TRAF3IP1 [cilium] (R-HSA-5617603)	0.508	3

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