USP13 binds SIAH2

Stable Identifier
R-HSA-6781899
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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USP13 binds SIAH2
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USP13 mediates stabilization of the E3-ligase SIAH2 independently of deubiquitinase activity by binding and impairing SIAH2 autoubiquitination (Scortegagna et al. 2011).
Literature References
PubMed ID Title Journal Year
21659512 USP13 enzyme regulates Siah2 ligase stability and activity via noncatalytic ubiquitin-binding domains

Scortegagna, M, Gu, W, Kim, H, Kluger, H, Subtil, T, Qi, J, Ronai, ZA, Zhao, W

J. Biol. Chem. 2011
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Orthologous Events
USP13 binds SIAH2 (Bos taurus)
USP13 binds SIAH2 (Canis familiaris)
USP13 binds SIAH2 (Danio rerio)
USP13 binds SIAH2 (Drosophila melanogaster)
USP13 binds SIAH2 (Gallus gallus)
USP13 binds SIAH2 (Mus musculus)
USP13 binds SIAH2 (Rattus norvegicus)
USP13 binds SIAH2 (Sus scrofa)
Authored
Jupe, S  (2015-04-16)
Reviewed
Meldal, BH  (2016-05-16)
Created
Jupe, S  (2015-06-03)
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