ERCC6 binds stalled RNA Pol II

Stable Identifier
R-HSA-6781840
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Cockayne syndrome protein B (ERCC6, also known as CSB) binds RNA polymerase II complex (RNA Pol II) stalled at a DNA damage site and is required for the subsequent recruitment of ERCC8 (CSA) (Kamiuchi et al. 2002, van der Weegen et al. 2020).
Literature References
PubMed ID Title Journal Year
32355176 The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II

González-Prieto, R, Golan-Berman, H, Adar, S, van den Heuvel, D, Luijsterburg, MS, van der Weegen, Y, Apelt, K, Vertegaal, ACO, Heilbrun, EE, Goedhart, J, Walter, JC, Mevissen, TET

Nat Commun 2020
11782547 Translocation of Cockayne syndrome group A protein to the nuclear matrix: possible relevance to transcription-coupled DNA repair

Kamiuchi, S, Tanaka, K, de Jager, M, Saijo, M, Citterio, E, Hoeijmakers, JH

Proc Natl Acad Sci U S A 2002
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