Reactome | TNFSF10 [extracellular region]

TNFSF10 [extracellular region]

Stable Identifier

R-HSA-66186

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

TRAIL, Tumor necrosis factor ligand superfamily member 10 (TNF-related apoptosis inducing ligand) (TRAIL protein) (Apo-2 ligand) (Apo-2L), Tumor necrosis factor ligand superfamily member 10, TNF-related apoptosis inducing ligand, TRAIL protein, Apo-2 ligand, Apo-2L

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Locations in the PathwayBrowser for interactor UniProt:O00220%20TNFRSF10A

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External Reference Information

External Reference

UniProt:P50591 TNFSF10

Gene Names

TNFSF10, APO2L, TRAIL

Chain

chain:1-281

Reference Genes

BioGPS Gene:8743 TNFSF10

COSMIC (genes):TNFSF10 TNFSF10

CTD Gene:8743 TNFSF10

dbSNP Gene:8743 TNFSF10

ENSEMBL:ENSG00000121858 TNFSF10

ENSEMBL_homo_sapiens_GENE:ENSG00000121858.11 TNFSF10

HGNC:11925 TNFSF10

KEGG Gene (Homo sapiens):8743 TNFSF10

Monarch:8743 TNFSF10

NCBI Gene:8743 TNFSF10

OMIM:603598 TNFSF10

UCSC:P50591 TNFSF10

Reference Transcript

Other Identifiers

11743730_at

11743731_a_at

11747952_x_at

16961616

1715_at

202687_PM_s_at

202687_s_at

202688_PM_at

202688_at

214329_3p_x_at

214329_PM_x_at

214329_x_at

2705705

2705707

2705708

2705709

2705710

2705711

2705712

2705713

2705714

2705720

2705725

2705728

2705729

2705730

8092169

8743

A_23_P121253

A_33_P3226810

GE59115

GO:0002376

GO:0005102

GO:0005125

GO:0005164

GO:0005515

GO:0005576

GO:0005615

GO:0005886

GO:0006915

GO:0006955

GO:0007005

GO:0007154

GO:0007165

GO:0007267

GO:0008270

GO:0008584

GO:0012501

GO:0016020

GO:0022414

GO:0023052

GO:0032813

GO:0032868

GO:0042802

GO:0043065

GO:0043123

GO:0043226

GO:0043280

GO:0045569

GO:0046872

GO:0048018

GO:0048856

GO:0070062

GO:0090200

GO:0098772

GO:2001238

HMNXSV003055767

Hs.301527.0.A1_3p_x_at

ILMN_1801307

ILMN_1903064

PH_hs_0024437

TC03002006.hg

TC03003211.hg

U37518_at

g1336207_3p_a_at

Participates

as an input of

TRAIL binds TRAIL receptors (Homo sapiens)

as a component of

TNFSF10:TNFRSF10A,B [plasma membrane] (Homo sapiens)

Inferred To

Ghost homologue of TNFSF10 [extracellular region] (Sus scrofa)

TNFSF10 [extracellular region] (Bos taurus)

TNFSF10 [extracellular region] (Canis familiaris)

TNFSF10 [extracellular region] (Danio rerio)

TNFSF10 [extracellular region] (Gallus gallus)

TNFSF10 [extracellular region] (Mus musculus)

TNFSF10 [extracellular region] (Rattus norvegicus)

TNFSF10 [extracellular region] (Xenopus tropicalis)

Cross References

RefSeq

NP_003801.1, NP_001177871.1

OpenTargets

ENSG00000121858

HPA

ENSG00000121858-TNFSF10

GeneCards

P50591

Ensembl

ENSP00000241261, ENST00000420541, ENSG00000121858, ENSP00000389931, ENST00000241261

PRO

P50591

Pharos - Targets

P50591

Orphanet

25960

PDB

1DG6, 1D2Q, 1DU3, 5CIR, 1D4V, 1D0G, 4N90

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O14763 TNFRSF10B	1	TNFRSF10B [plasma membrane] (R-HSA-65505)	0.946	25
UniProt:Q14790 CASP8	8	CASP8(1-374) [cytosol] (R-HSA-3465404) CASP8(217-374) [mitochondrial outer membrane] (R-HSA-351869) CASP8(385-479) [mitochondrial outer membrane] (R-HSA-351828) CASP8(385-479) [cytosol] (R-HSA-76158) CASP8(375-384) [cytosol] (R-HSA-933460) CASP8(217-374) [cytosol] (R-HSA-75975) CASP8(1-216) [cytosol] (R-HSA-933456) CASP8(1-479) [cytosol] (R-HSA-57031)	0.919	20
UniProt:Q13158 FADD	1	FADD [cytosol] (R-HSA-54639)	0.913	19
UniProt:O15519-1 CFLAR	5	M1polyUb-K351,K353-CFLAR(1-480) [cytosol] (R-HSA-9794015) CFLAR(377-480) [cytosol] (R-HSA-3465483) K63polyUb-CFLAR(1-480) [cytosol] (R-HSA-9818805) CFLAR(1-376) [cytosol] (R-HSA-3465408) CFLAR(1-480) [cytosol] (R-HSA-3371356)	0.725	8
UniProt:O15519-2 CFLAR	1	FLIP(S) [cytosol] (R-HSA-3465357)	0.725	7
UniProt:O00220 TNFRSF10A	1	TNFRSF10A [plasma membrane] (R-HSA-5633393)	0.723	8
UniProt:O15519 CFLAR	1	CFLAR(1-376) [cytosol] (R-HSA-51925)	0.527	2