Reactome | DIABLO [mitochondrial intermembrane space]

DIABLO [mitochondrial intermembrane space]

Stable Identifier

R-HSA-64637

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial intermembrane space

Synonyms

Smac protein, mitochondrial precursor, Second mitochondria-derived activator of caspase, Direct IAP binding protein with low pI

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9NR28 DIABLO

Gene Names

DIABLO, SMAC

Chain

transit peptide:1-55, chain:56-239

Reference Genes

BioGPS Gene:56616 DIABLO

COSMIC (genes):DIABLO DIABLO

CTD Gene:56616 DIABLO

dbSNP Gene:56616 DIABLO

ENSEMBL:ENSG00000184047 DIABLO

ENSEMBL:ENSG00000284934 DIABLO

HGNC:21528 DIABLO

KEGG Gene (Homo sapiens):56616 DIABLO

Monarch:56616 DIABLO

NCBI Gene:56616 DIABLO

OMIM:605219 DIABLO

UCSC:Q9NR28 DIABLO

Reference Transcript

Other Identifiers

0001500450

0003140372

11741320_a_at

16688

16771632

1825

1FEW

1G3F

1G73

1OXQ

1TW6

1XB0

1XB1

219350_s_at

3475512

3475513

3475514

3475520

3475523

3475524

3475526

3475527

3475529

3475535

3475536

3475537

3475538

3475539

3475542

3857

3D9U

3UIH

3UIJ

4TX5

56616

65473_at

7967230

85778_at

A0A0S2Z5P6

A0A0S2Z5U7

A0A2R8Y4M2

A0A2R8Y5H2

A0A2U3TZH2

A_23_P47800

A_33_P3330125

AAF87716

AAG22077

AAH04417

AAH11909

AAQ86939

AC048338

AF262240

AF298770

AK024768

AK057778

AK315629

ALQ34183

ALQ34184

AY313210

BAB14994

BAB71568

BAG37997

BC004417

BC011909

CAB003857

CAB016688

CCDS9228

CCDS9229

DIABLO

DIABLO-203

DIABLO-206

DIABLO-216

ENSG00000184047

ENSG00000284934

ENSP00000320343

ENSP00000398495

ENSP00000442360

ENSP00000499058

ENST00000353548

ENST00000353548.11

ENST00000443649

ENST00000443649.8

ENST00000464942

ENST00000464942.7

ENST00000650715

EntrezGene:56616

EntrezGene:DIABLO

F5GX50

F5GXT8

g9845296_3p_a_at

GE55778

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005739

GO:0005758

GO:0005829

GO:0005886

GO:0006915

GO:0006919

GO:0006950

GO:0007165

GO:0008150

GO:0008219

GO:0008625

GO:0008631

GO:0008635

GO:0009898

GO:0016020

GO:0016021

GO:0032991

GO:0035631

GO:0043065

GO:0043226

GO:0051402

GO:0097193

H7BZQ7

HGNC:21528

HPA001825

ILMN_1689781

ILMN_2310589

ILMN_2332990

IPR009062

IPR015142

KU178725

KU178726

MIM:605219

MIM:614152

NM_001278303

NM_001278342

NM_019887

NM_138930

NP_001265232

NP_001265271

NP_063940

NP_620308

PF09057

PH_hs_0010113

TC12003130.hg

TC12003286.hg

UPI0000000CBE

UPI000013FD9C

Participant Of

input

Release of SMAC (DIABLO) from mitochondria

Other forms of this molecule

DIABLO [cytosol]

Inferred To

DIABLO [mitochondrial intermembrane space] (Bos taurus)

DIABLO [mitochondrial intermembrane space] (Canis familiaris)

DIABLO [mitochondrial intermembrane space] (Danio rerio)

DIABLO [mitochondrial intermembrane space] (Gallus gallus)

DIABLO [mitochondrial intermembrane space] (Mus musculus)

DIABLO [mitochondrial intermembrane space] (Rattus norvegicus)

DIABLO [mitochondrial intermembrane space] (Sus scrofa)

DIABLO [mitochondrial intermembrane space] (Xenopus tropicalis)

Cross References

RefSeq

NP_001265232.1, NP_063940.1, NP_001265271.1, NP_620308.1, NP_001265231.1, NP_001265233.1

OpenTargets

ENSG00000184047

GeneCards

Q9NR28

PRO

Q9NR28

Orphanet

20297

PDB

3UIH, 1G3F, 1G73, 1XB1, 1TW6, 1FEW, 4TX5, 3UIJ, 1OXQ, 3D9U, 1XB0

Interactors (29)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P98170 XIAP	3	XIAP [nucleoplasm] (R-HSA-3322366) K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [cytosol] (R-HSA-50849)	0.905	9
UniProt:Q15041 AR6P1			0.795	8
UniProt:Q13490 BIRC2	5	K48pUb-BIRC2 [cytosol] (R-HSA-5675479) K63polyUb-BIRC2 [cytosol] (R-HSA-5668512) BIRC2(1-372) [cytosol] (R-HSA-202913) BIRC2 [cytosol] (R-HSA-50847) BIRC2(373-618) [cytosol] (R-HSA-202931)	0.775	6
UniProt:Q6RW13-2 AGTRAP			0.696	5
UniProt:Q96CA5 BIRC7			0.591	6
UniProt:Q13489 BIRC3	3	K48pUb-BIRC3 [cytosol] (R-HSA-5675478) K63polyUb-BIRC3 [cytosol] (R-HSA-5668478) BIRC3 [cytosol] (R-HSA-50845)	0.564	2
UniProt:Q60989	3	XIAP [nucleoplasm] (R-MMU-3322366) K48pUb-XIAP [cytosol] (R-MMU-5675477) XIAP [cytosol] (R-MMU-50849)	0.564	3
UniProt:P10809 HSPD1	6	HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1 [mitochondrial matrix] (R-HSA-1299448) HSPD1(1-573) [cytosol] (R-HSA-1267989) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963)	0.527	5
UniProt:Q96FJ2 DYNLL2	4	DYNLL2 [cilium] (R-HSA-5624865) DYNLL2 [ciliary tip] (R-HSA-5625337) DYNLL2 [plasma membrane] (R-HSA-140527) DYNLL2 [cytosol] (R-HSA-2029024)	0.508	2
UniProt:P63167 DYNLL1	6	DYNLL1 [cilium] (R-HSA-5624863) DYNLL1 [ciliary tip] (R-HSA-5625335) DYNLL1 [tertiary granule membrane] (R-HSA-6801482) DYNLL1 [ficolin-1-rich granule membrane] (R-HSA-6801518) DYNLL1 [plasma membrane] (R-HSA-54017) DYNLL1 [cytosol] (R-HSA-387105)	0.508	2
UniProt:Q6ZPD8 DGAT2L6	1	DGAT2L6 [endoplasmic reticulum membrane] (R-HSA-8848588)	0.488	2
UniProt:Q96LJ7 DHRS1			0.488	2
UniProt:Q9H169-2 Q9H1692			0.488	2
UniProt:O95563 MPC2	1	MPC2 [mitochondrial inner membrane] (R-HSA-2512891)	0.488	2
UniProt:Q8N9I5 FADS6			0.488	2
UniProt:Q7Z5P4 HSD17B13	1	HSD17B13 [cytosol] (R-HSA-8862029)	0.488	2
UniProt:Q96IW7 SEC22A	3	SEC22A [endoplasmic reticulum membrane] (R-HSA-5216111) SEC22A [ER to Golgi transport vesicle membrane] (R-HSA-5688560) SEC22A [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688562)	0.488	2
UniProt:Q9Y680 FKBP7			0.488	2
UniProt:Q8WV19 SFT2A			0.488	2
UniProt:Q15390 MTFR1			0.488	2
IntAct:EBI-18253661 LINC01142			0.488	2
UniProt:Q9BYT1 S17A9			0.488	2
UniProt:Q6NTF9-3 Q6NTF93			0.488	2
UniProt:Q9GZP9 DERL2	1	DERL2 [endoplasmic reticulum membrane] (R-HSA-5362350)	0.488	2
UniProt:Q96LZ7 RMD2			0.488	2
UniProt:Q8IZR5-2 Q8IZR52			0.488	2
UniProt:Q8N2U9 S66A2			0.488	2
UniProt:P55056 APOC4	1	APOC4 [extracellular region] (R-HSA-5215930)	0.488	2
UniProt:Q5XKP0 MICOS13	1	MIC13 (QIL1) [mitochondrial inner membrane] (R-HSA-8949561)	0.488	2