Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
GART [cytosol]
Stable Identifier
R-HSA-62498
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase, Trifunctional purine biosynthetic protein adenosine-3 (Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIRS) (Phosphoribosyl-aminoimidazole synthetase) (AIR synthase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (GART) (GAR transformylase) (5'-phosphoribosylglycinamide transformylase)), Trifunctional purine biosynthetic protein adenosine-3, Phosphoribosylamine--glycine ligase , GARS, Glycinamide ribonucleotide synthetase, Phosphoribosylglycinamide synthetase, Phosphoribosylformylglycinamidine cyclo-ligase , AIRS, Phosphoribosyl-aminoimidazole synthetase, AIR synthase, Phosphoribosylglycinamide formyltransferase , GAR transformylase, 5'-phosphoribosylglycinamide transformylase
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of nucleotides (Homo sapiens)
Nucleotide biosynthesis (Homo sapiens)
Purine ribonucleoside monophosphate biosynthesis (Homo sapiens)
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Homo sapiens)
GART [cytosol] (Homo sapiens)
FGAM + ATP => AIR + ADP + Pi (Homo sapiens)
GART [cytosol] (Homo sapiens)
GAR + 10-Formyl-THF => FGAR + THF (Homo sapiens)
GART [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P22102 GART
Gene Names
GART, PGFT, PRGS
Chain
initiator methionine:, chain:2-1010
Reference Genes
BioGPS Gene:2618 GART
COSMIC (genes):GART GART
CTD Gene:2618 GART
dbSNP Gene:2618 GART
ENSEMBL:ENSG00000159131 GART
ENSEMBL_homo_sapiens_GENE:ENSG00000159131.17 GART
ENSEMBL_homo_sapiens_GENE:ENSG00000262473.5 GART
HGNC:4163 GART
KEGG Gene (Homo sapiens):2618 GART
Monarch:2618 GART
NCBI Gene:2618 GART
OMIM:138440 GART
UCSC:P22102 GART
Reference Transcript
RefSeq:XM_006723990.1 GART
RefSeq:XM_011529526.1 GART
RefSeq:NM_001136005.1 GART
RefSeq:NM_000819.4 GART
RefSeq:NM_001136006.1 GART
RefSeq:XM_005260941.1 GART
RefSeq:NM_175085.2 GART
RefSeq:XM_006723989.1 GART
Other Identifiers
11720968_a_at
11720969_a_at
11722930_x_at
11722931_a_at
16925194
210005_PM_at
210005_at
212378_PM_at
212378_at
212379_PM_at
212379_at
217445_PM_s_at
217445_s_at
2618
38384_at
3929722
3929723
3929724
3929725
3929726
3929727
3929729
3929731
3929732
3929733
3929734
3929736
3929738
3929739
3929740
3929741
3929745
3929746
3929747
3929748
3929749
3929750
3929753
3929755
3929757
3929758
3929759
3929760
3929761
3929762
3929763
3929764
8070102
A_23_P80098
A_24_P239140
A_24_P301846
GE59791
GO:0000166
GO:0003360
GO:0003824
GO:0004637
GO:0004641
GO:0004644
GO:0005524
GO:0005576
GO:0005615
GO:0005829
GO:0006164
GO:0006177
GO:0006189
GO:0006520
GO:0006544
GO:0006575
GO:0008152
GO:0009058
GO:0009113
GO:0009168
GO:0010033
GO:0010035
GO:0016740
GO:0016874
GO:0021549
GO:0021987
GO:0043226
GO:0044208
GO:0046084
GO:0046654
GO:0046872
GO:0048856
GO:0055086
GO:0070062
GO:0072522
GO:0097294
GO:1901135
HMNXSV003000881
HMNXSV003048682
Hs.82285.1.S1_3p_at
Hs.82285.1.S2_3p_at
Hs.82285.2.S1_3p_a_at
ILMN_1679476
ILMN_1793220
ILMN_1800020
PH_hs_0004709
TC21000412.hg
X54199_s_at
g509032_3p_at
Inferred To
GART [cytosol]
(Bos taurus)
GART [cytosol]
(Caenorhabditis elegans)
GART [cytosol]
(Canis familiaris)
GART [cytosol]
(Dictyostelium discoideum)
GART [cytosol]
(Drosophila melanogaster)
GART [cytosol]
(Gallus gallus)
GART [cytosol]
(Mus musculus)
GART [cytosol]
(Saccharomyces cerevisiae)
GART [cytosol]
(Schizosaccharomyces pombe)
GART [cytosol]
(Sus scrofa)
Gart [cytosol]
(Rattus norvegicus)
wu:fb33g04 [cytosol]
(Danio rerio)
gart [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001129478.1
,
NP_000810.1
,
XP_005260998.1
,
XP_006724052.1
,
XP_006724053.1
,
NP_780294.1
,
XP_011527828.1
,
NP_001129477.1
ZINC - World Drugs
PUR2_HUMAN
Guide to Pharmacology - Targets
2612
OpenTargets
ENSG00000159131
ZINC - FDA approved
PUR2_HUMAN
ZINC - Substances
PUR2_HUMAN
ZINC target
P22102
PRO
P22102
PDB
1MEJ
,
1NJS
,
1ZLX
,
1ZLY
,
1RBM
,
4ZZ1
,
4ZZ2
,
4ZYU
,
8FDY
,
4EW1
,
4EW2
,
7JG0
,
8FDX
,
4ZZ3
,
4ZYT
,
1MEN
,
1MEO
,
7JG4
,
2QK4
,
1RBQ
,
4EW3
,
7JG3
,
8FDZ
,
1RC0
,
8FE0
,
1RBY
,
4ZYV
,
4ZYW
,
2V9Y
,
5J9F
,
4ZYZ
,
4ZYX
,
4ZYY
,
1RC1
,
4ZZ0
,
1RBZ
ZINC - Investigational
PUR2_HUMAN
GeneCards
P22102
HPA
ENSG00000159131-GART
Ensembl
ENST00000381815
,
ENST00000381839
,
ENSP00000354388
,
ENST00000575273
,
ENSP00000459532
,
ENST00000381831
,
ENSP00000371236
,
ENSP00000371261
,
ENSP00000371253
,
ENSG00000159131
,
ENST00000571089
,
ENSG00000262473
,
ENSP00000461700
,
ENSP00000459391
,
ENST00000573055
,
ENST00000361093
Pharos - Targets
P22102
ZINC - Predictions - Purchasable
PUR2_HUMAN
HMDB Protein
HMDBP00330
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
8
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text