PIKE-L interaction with UNC5B

Stable Identifier
R-HSA-622357
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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PIKE-L a brain-specific GTPase selectively associates with UNC5B but not with other family members of UNC5. Netrin-1 enhances this interaction and this interaction triggers the activation of PI3K kinase signalling, prevents UNC5B's pro-apoptotic activity and enhances neuronal survival.
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