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PLCB3 [cytosol]
Stable Identifier
R-HSA-61747
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PLCB3, PLC beta 3, Phosphoinositide phospholipase C, PLC-beta-3, Phospholipase C-beta-3, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3
Icon
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Inositol phosphate metabolism (Homo sapiens)
Synthesis of IP3 and IP4 in the cytosol (Homo sapiens)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Homo sapiens)
PLCbz [cytosol] (Homo sapiens)
PLCB3:Ca2+ [cytosol] (Homo sapiens)
PLCB3 [cytosol] (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
Regulation of insulin secretion (Homo sapiens)
Acetylcholine regulates insulin secretion (Homo sapiens)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Homo sapiens)
PLC beta1,2,3 [cytosol] (Homo sapiens)
PLCB3 [cytosol] (Homo sapiens)
PLC beta1,2,3:G-alpha(q):GTP [plasma membrane] (Homo sapiens)
PLC beta1,2,3 [cytosol] (Homo sapiens)
PLCB3 [cytosol] (Homo sapiens)
Gq alpha activates Phospholipase C beta (Homo sapiens)
PLC beta1,2,3 [cytosol] (Homo sapiens)
PLCB3 [cytosol] (Homo sapiens)
PLC beta1,2,3:G-alpha(q):GTP [plasma membrane] (Homo sapiens)
PLC beta1,2,3 [cytosol] (Homo sapiens)
PLCB3 [cytosol] (Homo sapiens)
Free fatty acids regulate insulin secretion (Homo sapiens)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Homo sapiens)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Homo sapiens)
PLC beta1,2,3 [cytosol] (Homo sapiens)
PLCB3 [cytosol] (Homo sapiens)
PLC beta1,2,3:G-alpha(q):GTP [plasma membrane] (Homo sapiens)
PLC beta1,2,3 [cytosol] (Homo sapiens)
PLCB3 [cytosol] (Homo sapiens)
Gq alpha activates Phospholipase C beta (Homo sapiens)
PLC beta1,2,3 [cytosol] (Homo sapiens)
PLCB3 [cytosol] (Homo sapiens)
PLC beta1,2,3:G-alpha(q):GTP [plasma membrane] (Homo sapiens)
PLC beta1,2,3 [cytosol] (Homo sapiens)
PLCB3 [cytosol] (Homo sapiens)
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of kainate receptors upon glutamate binding (Homo sapiens)
Presynaptic function of Kainate receptors (Homo sapiens)
Activation of GRIK3 homomer (Homo sapiens)
G-protein beta-gamma:PLC beta 1/2/3 [plasma membrane] (Homo sapiens)
PLC-beta 1/2/3 [cytosol] (Homo sapiens)
PLCB3 [cytosol] (Homo sapiens)
Kainate receptor-glutamate-Gprotein complex [plasma membrane] (Homo sapiens)
G-protein beta-gamma:PLC beta 1/2/3 [plasma membrane] (Homo sapiens)
PLC-beta 1/2/3 [cytosol] (Homo sapiens)
PLCB3 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Opioid Signalling (Homo sapiens)
G-protein mediated events (Homo sapiens)
PLC beta mediated events (Homo sapiens)
Activation of PLC beta-1/4 (Homo sapiens)
Activated PLC beta 1/4 [plasma membrane] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB3 [cytosol] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB3 [cytosol] (Homo sapiens)
Inactivation of PLC beta (Homo sapiens)
Activated PLC beta 1/4 [plasma membrane] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB3 [cytosol] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB3 [cytosol] (Homo sapiens)
PIP2 hydrolysis (Homo sapiens)
Activated PLC beta 1/4 [plasma membrane] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB3 [cytosol] (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
PLC beta is activated by G alpha (q) (Homo sapiens)
PLC beta:G alpha (q/11) [plasma membrane] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB3 [cytosol] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB3 [cytosol] (Homo sapiens)
PLC-beta hydrolyses PIP2 to DAG and IP3 (Homo sapiens)
PLC beta:G alpha (q/11) [plasma membrane] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB3 [cytosol] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB3 [cytosol] (Homo sapiens)
PLC-beta:G-alpha(q/11):DAG:IP3 [plasma membrane] (Homo sapiens)
PLC beta:G alpha (q/11) [plasma membrane] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB3 [cytosol] (Homo sapiens)
PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] (Homo sapiens)
PLC beta:G alpha (q/11) [plasma membrane] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB3 [cytosol] (Homo sapiens)
G-protein beta:gamma signalling (Homo sapiens)
G beta:gamma signalling through PLC beta (Homo sapiens)
Gbeta:gamma activation of PLC beta (Homo sapiens)
G-protein beta-gamma:PLC beta 1/2/3 [plasma membrane] (Homo sapiens)
PLC-beta 1/2/3 [cytosol] (Homo sapiens)
PLCB3 [cytosol] (Homo sapiens)
PLC-beta 1/2/3 [cytosol] (Homo sapiens)
PLCB3 [cytosol] (Homo sapiens)
PLC beta-mediated PIP2 hydrolysis (Homo sapiens)
G-protein beta-gamma:PLC beta 1/2/3 [plasma membrane] (Homo sapiens)
PLC-beta 1/2/3 [cytosol] (Homo sapiens)
PLCB3 [cytosol] (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
Ca2+ pathway (Homo sapiens)
Gbeta:gamma activation of PLC beta (Homo sapiens)
G-protein beta-gamma:PLC beta 1/2/3 [plasma membrane] (Homo sapiens)
PLC-beta 1/2/3 [cytosol] (Homo sapiens)
PLCB3 [cytosol] (Homo sapiens)
PLC-beta 1/2/3 [cytosol] (Homo sapiens)
PLCB3 [cytosol] (Homo sapiens)
PLC beta-mediated PIP2 hydrolysis (Homo sapiens)
G-protein beta-gamma:PLC beta 1/2/3 [plasma membrane] (Homo sapiens)
PLC-beta 1/2/3 [cytosol] (Homo sapiens)
PLCB3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q01970 PLCB3
Gene Names
PLCB3
Chain
initiator methionine:, chain:2-1234
Reference Genes
BioGPS Gene:5331 PLCB3
COSMIC (genes):PLCB3 PLCB3
CTD Gene:5331 PLCB3
dbSNP Gene:5331 PLCB3
ENSEMBL:ENSG00000149782 PLCB3
ENSEMBL_homo_sapiens_GENE:ENSG00000149782.13 PLCB3
HGNC:9056 PLCB3
KEGG Gene (Homo sapiens):5331 PLCB3
Monarch:5331 PLCB3
NCBI Gene:5331 PLCB3
OMIM:600230 PLCB3
UCSC:Q01970 PLCB3
Reference Transcript
RefSeq:NM_000932.2 PLCB3
RefSeq:NM_001184883.1 PLCB3
RefSeq:NM_001316314.1 PLCB3
Other Identifiers
11715304_s_at
11763461_x_at
16726336
213384_PM_x_at
213384_x_at
3334373
3334374
3334375
3334376
3334377
3334379
3334380
3334381
3334382
3334383
3334384
3334385
3334386
3334387
3334388
3334389
3334390
3334391
3334392
3334393
3334394
3334395
3334396
3334398
3334400
3334401
3334402
3334403
3334404
3334405
3334406
3334407
3334408
3334409
3334410
3334411
3334412
3334413
3334414
364_s_at
5331
7940924
87490_at
A_23_P343719
A_33_P3260623
GE60404
GO:0003013
GO:0003073
GO:0003824
GO:0004435
GO:0004629
GO:0005509
GO:0005515
GO:0005516
GO:0005634
GO:0005737
GO:0005829
GO:0006629
GO:0007165
GO:0007186
GO:0008081
GO:0016020
GO:0016042
GO:0016787
GO:0023052
GO:0032991
GO:0035556
GO:0043226
GO:0045296
GO:0046488
GO:0048015
GO:0051209
GO:0055065
GO:0055085
GO:0060090
GO:0098772
GO:0099524
GO:0140677
HMNXSV003039970
HMNXSV003048378
Hs.37121.0.S1_3p_a_at
ILMN_1714041
PH_hs_0033406
TC11000592.hg
Z16411_s_at
Participates
as a candidate of
PLC beta1,2,3 [cytosol] (Homo sapiens)
as a member of
PLC-beta 1/2/3 [cytosol] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
as a component of
PLCB3:Ca2+ [cytosol] (Homo sapiens)
Inferred To
Plcb3 [cytosol]
(Mus musculus)
Plcb3 [cytosol]
(Rattus norvegicus)
PLCB3 [cytosol]
(Canis familiaris)
PLCB3 [cytosol]
(Dictyostelium discoideum)
PLCB3 [cytosol]
(Drosophila melanogaster)
PLCB3 [cytosol]
(Plasmodium falciparum)
PLCB3 [cytosol]
(Saccharomyces cerevisiae)
PLCB3 [cytosol]
(Schizosaccharomyces pombe)
PLCB3 [cytosol]
(Sus scrofa)
PLCB3 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001171812.1
,
NP_000923.1
,
NP_001303243.1
Guide to Pharmacology - Targets
1405
OpenTargets
ENSG00000149782
IntEnz
3.1.4.11
HPA
ENSG00000149782-PLCB3
GeneCards
Q01970
Ensembl
ENST00000325234
,
ENSP00000443631
,
ENSP00000279230
,
ENSG00000149782
,
ENST00000279230
,
ENSP00000324660
,
ENST00000540288
PRO
Q01970
Pharos - Targets
Q01970
Orphanet
26405
HMDB Protein
HMDBP00228
PDB
8EMW
,
4QJ3
,
4GNK
,
4QJ5
,
8EMV
,
7SQ2
,
4QJ4
,
8EMX
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